![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: FAM46C |
Gene summary for FAM46C |
![]() |
Gene information | Species | Human | Gene symbol | FAM46C | Gene ID | 54855 |
Gene name | terminal nucleotidyltransferase 5C | |
Gene Alias | FAM46C | |
Cytomap | 1p12 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | Q5VWP2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54855 | FAM46C | P1T-E | Human | Esophagus | ESCC | 1.59e-02 | 1.70e-01 | 0.0875 |
54855 | FAM46C | P2T-E | Human | Esophagus | ESCC | 5.58e-09 | 2.64e-01 | 0.1177 |
54855 | FAM46C | P4T-E | Human | Esophagus | ESCC | 7.85e-04 | 1.21e-01 | 0.1323 |
54855 | FAM46C | P5T-E | Human | Esophagus | ESCC | 2.90e-03 | -2.10e-02 | 0.1327 |
54855 | FAM46C | P8T-E | Human | Esophagus | ESCC | 2.16e-14 | 2.54e-01 | 0.0889 |
54855 | FAM46C | P10T-E | Human | Esophagus | ESCC | 2.17e-07 | 1.22e-02 | 0.116 |
54855 | FAM46C | P11T-E | Human | Esophagus | ESCC | 5.89e-09 | 5.98e-01 | 0.1426 |
54855 | FAM46C | P12T-E | Human | Esophagus | ESCC | 6.02e-07 | 9.88e-02 | 0.1122 |
54855 | FAM46C | P15T-E | Human | Esophagus | ESCC | 1.61e-04 | 9.52e-02 | 0.1149 |
54855 | FAM46C | P16T-E | Human | Esophagus | ESCC | 3.83e-06 | 2.33e-02 | 0.1153 |
54855 | FAM46C | P20T-E | Human | Esophagus | ESCC | 1.27e-04 | 1.60e-01 | 0.1124 |
54855 | FAM46C | P21T-E | Human | Esophagus | ESCC | 8.51e-07 | 4.83e-02 | 0.1617 |
54855 | FAM46C | P23T-E | Human | Esophagus | ESCC | 6.71e-05 | 1.41e-01 | 0.108 |
54855 | FAM46C | P24T-E | Human | Esophagus | ESCC | 2.99e-03 | -2.59e-02 | 0.1287 |
54855 | FAM46C | P26T-E | Human | Esophagus | ESCC | 1.13e-07 | 3.82e-02 | 0.1276 |
54855 | FAM46C | P27T-E | Human | Esophagus | ESCC | 2.19e-03 | 3.59e-02 | 0.1055 |
54855 | FAM46C | P28T-E | Human | Esophagus | ESCC | 2.43e-03 | -1.98e-02 | 0.1149 |
54855 | FAM46C | P31T-E | Human | Esophagus | ESCC | 1.72e-11 | 6.05e-02 | 0.1251 |
54855 | FAM46C | P32T-E | Human | Esophagus | ESCC | 4.90e-02 | -7.81e-02 | 0.1666 |
54855 | FAM46C | P39T-E | Human | Esophagus | ESCC | 4.82e-03 | -1.58e-02 | 0.0894 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM46C | SNV | Missense_Mutation | novel | c.473N>T | p.Ser158Phe | p.S158F | Q5VWP2 | protein_coding | deleterious(0.03) | possibly_damaging(0.825) | TCGA-TN-A7HL-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
FAM46C | SNV | Missense_Mutation | c.361N>T | p.Pro121Ser | p.P121S | Q5VWP2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM46C | SNV | Missense_Mutation | c.208C>T | p.Arg70Trp | p.R70W | Q5VWP2 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD | |
FAM46C | SNV | Missense_Mutation | novel | c.386N>A | p.Ile129Asn | p.I129N | Q5VWP2 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |