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Gene: FAM222B |
Gene summary for FAM222B |
Gene summary. |
Gene information | Species | Human | Gene symbol | FAM222B | Gene ID | 55731 |
Gene name | family with sequence similarity 222 member B | |
Gene Alias | C17orf63 | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024QZ60 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55731 | FAM222B | CCI_2 | Human | Cervix | CC | 6.76e-05 | 5.48e-01 | 0.5249 |
55731 | FAM222B | CCI_3 | Human | Cervix | CC | 8.62e-11 | 7.44e-01 | 0.516 |
55731 | FAM222B | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.81e-08 | -3.78e-01 | 0.0155 |
55731 | FAM222B | HTA11_347_2000001011 | Human | Colorectum | AD | 3.05e-03 | 3.85e-01 | -0.1954 |
55731 | FAM222B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.68e-05 | -4.29e-01 | 0.294 |
55731 | FAM222B | F007 | Human | Colorectum | FAP | 2.21e-04 | -4.43e-01 | 0.1176 |
55731 | FAM222B | A002-C-010 | Human | Colorectum | FAP | 1.27e-03 | -3.86e-01 | 0.242 |
55731 | FAM222B | A001-C-207 | Human | Colorectum | FAP | 4.16e-06 | -4.70e-01 | 0.1278 |
55731 | FAM222B | A015-C-203 | Human | Colorectum | FAP | 5.01e-32 | -6.51e-01 | -0.1294 |
55731 | FAM222B | A015-C-204 | Human | Colorectum | FAP | 9.96e-12 | -6.11e-01 | -0.0228 |
55731 | FAM222B | A014-C-040 | Human | Colorectum | FAP | 3.90e-09 | -7.32e-01 | -0.1184 |
55731 | FAM222B | A002-C-201 | Human | Colorectum | FAP | 4.63e-16 | -5.58e-01 | 0.0324 |
55731 | FAM222B | A002-C-203 | Human | Colorectum | FAP | 5.11e-05 | -4.17e-01 | 0.2786 |
55731 | FAM222B | A001-C-119 | Human | Colorectum | FAP | 5.03e-03 | -2.30e-01 | -0.1557 |
55731 | FAM222B | A001-C-108 | Human | Colorectum | FAP | 1.73e-19 | -5.20e-01 | -0.0272 |
55731 | FAM222B | A002-C-205 | Human | Colorectum | FAP | 1.02e-23 | -5.62e-01 | -0.1236 |
55731 | FAM222B | A001-C-104 | Human | Colorectum | FAP | 3.25e-04 | -4.37e-01 | 0.0184 |
55731 | FAM222B | A015-C-005 | Human | Colorectum | FAP | 2.30e-06 | -4.67e-01 | -0.0336 |
55731 | FAM222B | A015-C-006 | Human | Colorectum | FAP | 1.12e-18 | -6.13e-01 | -0.0994 |
55731 | FAM222B | A015-C-106 | Human | Colorectum | FAP | 1.10e-12 | -4.25e-01 | -0.0511 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM222B | SNV | Missense_Mutation | novel | c.1411N>A | p.Leu471Ile | p.L471I | Q8WU58 | protein_coding | tolerated(0.11) | benign(0.162) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
FAM222B | SNV | Missense_Mutation | rs774613714 | c.223N>T | p.Arg75Cys | p.R75C | Q8WU58 | protein_coding | tolerated(0.05) | benign(0.019) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM222B | SNV | Missense_Mutation | novel | c.109N>A | p.Ala37Thr | p.A37T | Q8WU58 | protein_coding | tolerated(0.09) | benign(0.237) | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM222B | SNV | Missense_Mutation | novel | c.1077N>G | p.Asp359Glu | p.D359E | Q8WU58 | protein_coding | tolerated(0.59) | benign(0.003) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM222B | SNV | Missense_Mutation | novel | c.44N>G | p.Leu15Arg | p.L15R | Q8WU58 | protein_coding | deleterious(0.05) | probably_damaging(0.998) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM222B | SNV | Missense_Mutation | rs770786658 | c.691N>T | p.Arg231Trp | p.R231W | Q8WU58 | protein_coding | tolerated(0.06) | possibly_damaging(0.832) | TCGA-EY-A1GO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
FAM222B | insertion | Frame_Shift_Ins | rs764940150 | c.719dupC | p.Asn241GlufsTer27 | p.N241Efs*27 | Q8WU58 | protein_coding | TCGA-AP-A0L8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
FAM222B | insertion | Frame_Shift_Ins | rs764940150 | c.719_720insC | p.Asn241GlufsTer27 | p.N241Efs*27 | Q8WU58 | protein_coding | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FAM222B | SNV | Missense_Mutation | novel | c.1239N>C | p.Glu413Asp | p.E413D | Q8WU58 | protein_coding | tolerated(0.07) | possibly_damaging(0.84) | TCGA-2V-A95S-01 | Liver | liver hepatocellular carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
FAM222B | SNV | Missense_Mutation | novel | c.181N>G | p.Ile61Val | p.I61V | Q8WU58 | protein_coding | deleterious(0) | benign(0.031) | TCGA-DD-AAEB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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