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Gene: FAM105A |
Gene summary for FAM105A |
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Gene information | Species | Human | Gene symbol | FAM105A | Gene ID | 54491 |
Gene name | OTU deubiquitinase with linear linkage specificity like | |
Gene Alias | FAM105A | |
Cytomap | 5p15.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NUU6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54491 | FAM105A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.40e-44 | 8.35e-01 | 0.294 |
54491 | FAM105A | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.60e-16 | 1.14e+00 | 0.3487 |
54491 | FAM105A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.54e-19 | 4.74e-01 | 0.281 |
54491 | FAM105A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.40e-53 | 1.05e+00 | 0.3859 |
54491 | FAM105A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.26e-07 | 2.82e-01 | 0.2585 |
54491 | FAM105A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.05e-06 | 1.62e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM105A | SNV | Missense_Mutation | c.907T>C | p.Phe303Leu | p.F303L | Q9NUU6 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
FAM105A | SNV | Missense_Mutation | novel | c.1052N>T | p.Tyr351Phe | p.Y351F | Q9NUU6 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-85-A4JB-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | CR |
FAM105A | SNV | Missense_Mutation | novel | c.571A>G | p.Thr191Ala | p.T191A | Q9NUU6 | protein_coding | tolerated(0.23) | benign(0.183) | TCGA-85-A50Z-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | etoposide | PD |
FAM105A | SNV | Missense_Mutation | novel | c.328N>A | p.Arg110Ser | p.R110S | Q9NUU6 | protein_coding | tolerated(0.16) | benign(0.095) | TCGA-CV-7103-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
FAM105A | SNV | Missense_Mutation | novel | c.686N>G | p.Leu229Arg | p.L229R | Q9NUU6 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-CV-7432-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FAM105A | deletion | Frame_Shift_Del | novel | c.283_286delGATT | p.Asp95TyrfsTer18 | p.D95Yfs*18 | Q9NUU6 | protein_coding | TCGA-HC-7748-01 | Prostate | prostate adenocarcinoma | Male | <65 | 6 | Unknown | Unknown | SD | ||
FAM105A | SNV | Missense_Mutation | c.323C>T | p.Thr108Ile | p.T108I | Q9NUU6 | protein_coding | deleterious(0) | possibly_damaging(0.647) | TCGA-B7-5818-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAM105A | SNV | Missense_Mutation | c.1042G>A | p.Asp348Asn | p.D348N | Q9NUU6 | protein_coding | deleterious(0) | possibly_damaging(0.759) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM105A | SNV | Missense_Mutation | rs768937348 | c.371N>A | p.Arg124Gln | p.R124Q | Q9NUU6 | protein_coding | tolerated(0.12) | benign(0.007) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
FAM105A | SNV | Missense_Mutation | novel | c.328N>A | p.Arg110Ser | p.R110S | Q9NUU6 | protein_coding | tolerated(0.16) | benign(0.095) | TCGA-EM-A2CL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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