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Gene: FADS3 |
Gene summary for FADS3 |
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Gene information | Species | Human | Gene symbol | FADS3 | Gene ID | 3995 |
Gene name | fatty acid desaturase 3 | |
Gene Alias | CYB5RP | |
Cytomap | 11q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | A0A024R564 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3995 | FADS3 | LZE7T | Human | Esophagus | ESCC | 1.29e-05 | 2.29e-01 | 0.0667 |
3995 | FADS3 | P2T-E | Human | Esophagus | ESCC | 5.19e-03 | 1.03e-01 | 0.1177 |
3995 | FADS3 | P4T-E | Human | Esophagus | ESCC | 2.63e-17 | 3.89e-01 | 0.1323 |
3995 | FADS3 | P5T-E | Human | Esophagus | ESCC | 4.72e-32 | 6.24e-01 | 0.1327 |
3995 | FADS3 | P10T-E | Human | Esophagus | ESCC | 2.94e-13 | 2.81e-01 | 0.116 |
3995 | FADS3 | P11T-E | Human | Esophagus | ESCC | 8.82e-20 | 7.17e-01 | 0.1426 |
3995 | FADS3 | P12T-E | Human | Esophagus | ESCC | 7.35e-11 | 1.70e-01 | 0.1122 |
3995 | FADS3 | P15T-E | Human | Esophagus | ESCC | 5.80e-05 | 1.99e-01 | 0.1149 |
3995 | FADS3 | P16T-E | Human | Esophagus | ESCC | 5.31e-13 | 2.51e-01 | 0.1153 |
3995 | FADS3 | P17T-E | Human | Esophagus | ESCC | 1.36e-03 | 2.49e-01 | 0.1278 |
3995 | FADS3 | P19T-E | Human | Esophagus | ESCC | 2.78e-11 | 6.77e-01 | 0.1662 |
3995 | FADS3 | P20T-E | Human | Esophagus | ESCC | 1.52e-04 | 1.88e-01 | 0.1124 |
3995 | FADS3 | P21T-E | Human | Esophagus | ESCC | 5.41e-33 | 6.53e-01 | 0.1617 |
3995 | FADS3 | P22T-E | Human | Esophagus | ESCC | 1.40e-08 | 2.05e-01 | 0.1236 |
3995 | FADS3 | P24T-E | Human | Esophagus | ESCC | 2.18e-14 | 2.65e-01 | 0.1287 |
3995 | FADS3 | P27T-E | Human | Esophagus | ESCC | 1.49e-04 | 1.82e-01 | 0.1055 |
3995 | FADS3 | P28T-E | Human | Esophagus | ESCC | 9.62e-25 | 5.21e-01 | 0.1149 |
3995 | FADS3 | P30T-E | Human | Esophagus | ESCC | 2.36e-02 | 1.27e-01 | 0.137 |
3995 | FADS3 | P31T-E | Human | Esophagus | ESCC | 8.16e-06 | 1.56e-01 | 0.1251 |
3995 | FADS3 | P32T-E | Human | Esophagus | ESCC | 8.31e-18 | 3.90e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066433 | Esophagus | ESCC | membrane lipid metabolic process | 130/8552 | 203/18723 | 9.29e-08 | 1.54e-06 | 130 |
GO:00066652 | Esophagus | ESCC | sphingolipid metabolic process | 96/8552 | 155/18723 | 3.21e-05 | 2.66e-04 | 96 |
GO:00066318 | Esophagus | ESCC | fatty acid metabolic process | 217/8552 | 390/18723 | 4.21e-05 | 3.39e-04 | 217 |
GO:00463948 | Esophagus | ESCC | carboxylic acid biosynthetic process | 175/8552 | 314/18723 | 1.98e-04 | 1.26e-03 | 175 |
GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
GO:000663112 | Liver | Cirrhotic | fatty acid metabolic process | 165/4634 | 390/18723 | 1.29e-14 | 1.26e-12 | 165 |
GO:001605312 | Liver | Cirrhotic | organic acid biosynthetic process | 139/4634 | 316/18723 | 4.28e-14 | 3.83e-12 | 139 |
GO:004639412 | Liver | Cirrhotic | carboxylic acid biosynthetic process | 137/4634 | 314/18723 | 1.40e-13 | 1.14e-11 | 137 |
GO:007233011 | Liver | Cirrhotic | monocarboxylic acid biosynthetic process | 93/4634 | 214/18723 | 1.43e-09 | 6.16e-08 | 93 |
GO:000663311 | Liver | Cirrhotic | fatty acid biosynthetic process | 70/4634 | 163/18723 | 2.57e-07 | 6.41e-06 | 70 |
GO:0006643 | Liver | Cirrhotic | membrane lipid metabolic process | 69/4634 | 203/18723 | 1.89e-03 | 1.19e-02 | 69 |
GO:003355911 | Liver | Cirrhotic | unsaturated fatty acid metabolic process | 43/4634 | 116/18723 | 2.09e-03 | 1.29e-02 | 43 |
GO:001605321 | Liver | HCC | organic acid biosynthetic process | 200/7958 | 316/18723 | 5.24e-14 | 3.22e-12 | 200 |
GO:000663122 | Liver | HCC | fatty acid metabolic process | 238/7958 | 390/18723 | 8.24e-14 | 4.84e-12 | 238 |
GO:004639421 | Liver | HCC | carboxylic acid biosynthetic process | 198/7958 | 314/18723 | 1.19e-13 | 6.78e-12 | 198 |
GO:007233021 | Liver | HCC | monocarboxylic acid biosynthetic process | 129/7958 | 214/18723 | 1.08e-07 | 2.09e-06 | 129 |
GO:000663321 | Liver | HCC | fatty acid biosynthetic process | 96/7958 | 163/18723 | 1.71e-05 | 1.85e-04 | 96 |
GO:00066431 | Liver | HCC | membrane lipid metabolic process | 115/7958 | 203/18723 | 3.17e-05 | 3.22e-04 | 115 |
GO:0006665 | Liver | HCC | sphingolipid metabolic process | 85/7958 | 155/18723 | 1.27e-03 | 6.92e-03 | 85 |
GO:00066432 | Oral cavity | OSCC | membrane lipid metabolic process | 111/7305 | 203/18723 | 4.02e-06 | 4.69e-05 | 111 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FADS3 | SNV | Missense_Mutation | novel | c.272T>G | p.Leu91Arg | p.L91R | Q9Y5Q0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-VQ-A925-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
FADS3 | insertion | In_Frame_Ins | novel | c.1223_1224insGCTGTG | p.Leu407_Cys408insTrpLeu | p.L407_C408insWL | Q9Y5Q0 | protein_coding | TCGA-BR-8297-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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