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Gene: F2RL1 |
Gene summary for F2RL1 |
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Gene information | Species | Human | Gene symbol | F2RL1 | Gene ID | 2150 |
Gene name | F2R like trypsin receptor 1 | |
Gene Alias | GPR11 | |
Cytomap | 5q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P55085 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2150 | F2RL1 | LZE4T | Human | Esophagus | ESCC | 1.16e-06 | -6.47e-02 | 0.0811 |
2150 | F2RL1 | LZE8T | Human | Esophagus | ESCC | 2.76e-02 | -9.72e-02 | 0.067 |
2150 | F2RL1 | LZE20T | Human | Esophagus | ESCC | 9.79e-03 | -2.53e-01 | 0.0662 |
2150 | F2RL1 | LZE24T | Human | Esophagus | ESCC | 5.02e-13 | 1.09e+00 | 0.0596 |
2150 | F2RL1 | P2T-E | Human | Esophagus | ESCC | 2.99e-04 | -5.82e-02 | 0.1177 |
2150 | F2RL1 | P5T-E | Human | Esophagus | ESCC | 3.33e-10 | -7.32e-02 | 0.1327 |
2150 | F2RL1 | P8T-E | Human | Esophagus | ESCC | 9.25e-06 | 1.52e-01 | 0.0889 |
2150 | F2RL1 | P9T-E | Human | Esophagus | ESCC | 6.24e-03 | 1.95e-01 | 0.1131 |
2150 | F2RL1 | P10T-E | Human | Esophagus | ESCC | 4.85e-09 | -1.74e-01 | 0.116 |
2150 | F2RL1 | P11T-E | Human | Esophagus | ESCC | 2.79e-02 | -1.36e-01 | 0.1426 |
2150 | F2RL1 | P12T-E | Human | Esophagus | ESCC | 2.84e-02 | 1.35e-01 | 0.1122 |
2150 | F2RL1 | P15T-E | Human | Esophagus | ESCC | 1.29e-13 | 5.18e-02 | 0.1149 |
2150 | F2RL1 | P16T-E | Human | Esophagus | ESCC | 1.28e-08 | -1.89e-01 | 0.1153 |
2150 | F2RL1 | P20T-E | Human | Esophagus | ESCC | 1.13e-05 | -1.49e-02 | 0.1124 |
2150 | F2RL1 | P21T-E | Human | Esophagus | ESCC | 1.57e-20 | 3.40e-02 | 0.1617 |
2150 | F2RL1 | P22T-E | Human | Esophagus | ESCC | 1.35e-05 | -1.95e-01 | 0.1236 |
2150 | F2RL1 | P24T-E | Human | Esophagus | ESCC | 4.13e-08 | -2.57e-01 | 0.1287 |
2150 | F2RL1 | P26T-E | Human | Esophagus | ESCC | 1.67e-07 | 4.22e-01 | 0.1276 |
2150 | F2RL1 | P27T-E | Human | Esophagus | ESCC | 1.02e-08 | -8.17e-02 | 0.1055 |
2150 | F2RL1 | P28T-E | Human | Esophagus | ESCC | 2.91e-10 | 3.28e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:004312318 | Esophagus | ESCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 132/8552 | 186/18723 | 2.07e-12 | 8.58e-11 | 132 |
GO:0043122110 | Esophagus | ESCC | regulation of I-kappaB kinase/NF-kappaB signaling | 167/8552 | 249/18723 | 6.11e-12 | 2.32e-10 | 167 |
GO:000724919 | Esophagus | ESCC | I-kappaB kinase/NF-kappaB signaling | 183/8552 | 281/18723 | 3.02e-11 | 1.01e-09 | 183 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:1902905111 | Esophagus | ESCC | positive regulation of supramolecular fiber organization | 142/8552 | 209/18723 | 5.51e-11 | 1.76e-09 | 142 |
GO:1902903111 | Esophagus | ESCC | regulation of supramolecular fiber organization | 237/8552 | 383/18723 | 9.06e-11 | 2.75e-09 | 237 |
GO:0044403111 | Esophagus | ESCC | biological process involved in symbiotic interaction | 186/8552 | 290/18723 | 1.43e-10 | 4.16e-09 | 186 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:01405465 | Esophagus | ESCC | defense response to symbiont | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:0030099111 | Esophagus | ESCC | myeloid cell differentiation | 232/8552 | 381/18723 | 1.22e-09 | 2.90e-08 | 232 |
GO:005149520 | Esophagus | ESCC | positive regulation of cytoskeleton organization | 147/8552 | 226/18723 | 2.93e-09 | 6.38e-08 | 147 |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
GO:003253520 | Esophagus | ESCC | regulation of cellular component size | 227/8552 | 383/18723 | 4.77e-08 | 8.60e-07 | 227 |
GO:003010018 | Esophagus | ESCC | regulation of endocytosis | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:003109818 | Esophagus | ESCC | stress-activated protein kinase signaling cascade | 154/8552 | 247/18723 | 8.53e-08 | 1.44e-06 | 154 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
GZMA | F2RL1 | GZMA_F2RL1 | PARs | Endometrium | Healthy |
CTSG | F2RL1 | CTSG_F2RL1 | PARs | GC | Healthy |
PRSS2 | F2RL1 | PRSS2_F2RL1 | PARs | GC | Healthy |
GZMA | F2RL1 | GZMA_F2RL1 | PARs | GC | Precancer |
GZMA | F2RL1 | GZMA_F2RL1 | PARs | Prostate | BPH |
GZMA | F2RL1 | GZMA_F2RL1 | PARs | Prostate | Healthy |
PRSS3 | F2RL1 | PRSS3_F2RL1 | PARs | Skin | ADJ |
CTSG | F2RL1 | CTSG_F2RL1 | PARs | Skin | ADJ |
GZMA | F2RL1 | GZMA_F2RL1 | PARs | Skin | ADJ |
CTSG | F2RL1 | CTSG_F2RL1 | PARs | Skin | AK |
GZMA | F2RL1 | GZMA_F2RL1 | PARs | Skin | AK |
CTSG | F2RL1 | CTSG_F2RL1 | PARs | Skin | Healthy |
GZMA | F2RL1 | GZMA_F2RL1 | PARs | Skin | Healthy |
GZMA | F2RL1 | GZMA_F2RL1 | PARs | THCA | Cancer |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
F2RL1 | SNV | Missense_Mutation | novel | c.286N>A | p.Ala96Thr | p.A96T | P55085 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
F2RL1 | SNV | Missense_Mutation | c.677N>C | p.Cys226Ser | p.C226S | P55085 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-6A-AB49-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
F2RL1 | SNV | Missense_Mutation | novel | c.254N>C | p.Val85Ala | p.V85A | P55085 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CN-4734-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
F2RL1 | SNV | Missense_Mutation | novel | c.805N>A | p.Leu269Met | p.L269M | P55085 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
F2RL1 | SNV | Missense_Mutation | rs370384052 | c.565N>G | p.Asn189Asp | p.N189D | P55085 | protein_coding | tolerated(0.38) | benign(0.363) | TCGA-VQ-A91S-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2150 | F2RL1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE, ENZYME | ERYTHROMYCIN | ERYTHROMYCIN | 18212111 | |
2150 | F2RL1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE, ENZYME | AC-55541 | CHEMBL493076 | 18720984 | |
2150 | F2RL1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE, ENZYME | agonist | 178100874 | ||
2150 | F2RL1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE, ENZYME | ROXITHROMYCIN | ROXITHROMYCIN | 18212111 | |
2150 | F2RL1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE, ENZYME | antagonist | 381744949 | ||
2150 | F2RL1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE, ENZYME | agonist | 178103272 | ||
2150 | F2RL1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE, ENZYME | antagonist | 178103271 | ||
2150 | F2RL1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE, ENZYME | agonist | 178100746 | ||
2150 | F2RL1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE, ENZYME | agonist | 178103269 | ||
2150 | F2RL1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE, ENZYME | antagonist | 178103270 |
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