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Gene: EVPL |
Gene summary for EVPL |
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Gene information | Species | Human | Gene symbol | EVPL | Gene ID | 2125 |
Gene name | envoplakin | |
Gene Alias | EVPK | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | B7ZLH8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2125 | EVPL | LZE2T | Human | Esophagus | ESCC | 2.11e-03 | 4.67e-01 | 0.082 |
2125 | EVPL | LZE4T | Human | Esophagus | ESCC | 1.12e-06 | 3.24e-01 | 0.0811 |
2125 | EVPL | LZE7T | Human | Esophagus | ESCC | 1.15e-04 | 3.03e-01 | 0.0667 |
2125 | EVPL | LZE8T | Human | Esophagus | ESCC | 3.53e-02 | 9.70e-02 | 0.067 |
2125 | EVPL | LZE20T | Human | Esophagus | ESCC | 3.88e-08 | 4.17e-01 | 0.0662 |
2125 | EVPL | LZE22T | Human | Esophagus | ESCC | 2.30e-07 | 5.14e-01 | 0.068 |
2125 | EVPL | LZE24T | Human | Esophagus | ESCC | 4.29e-11 | 2.31e-01 | 0.0596 |
2125 | EVPL | LZE21T | Human | Esophagus | ESCC | 7.37e-06 | 4.22e-01 | 0.0655 |
2125 | EVPL | P1T-E | Human | Esophagus | ESCC | 2.31e-12 | 6.36e-01 | 0.0875 |
2125 | EVPL | P2T-E | Human | Esophagus | ESCC | 2.16e-11 | 8.79e-02 | 0.1177 |
2125 | EVPL | P4T-E | Human | Esophagus | ESCC | 9.33e-06 | 1.49e-01 | 0.1323 |
2125 | EVPL | P5T-E | Human | Esophagus | ESCC | 9.23e-24 | 1.47e-01 | 0.1327 |
2125 | EVPL | P8T-E | Human | Esophagus | ESCC | 1.04e-17 | 2.40e-01 | 0.0889 |
2125 | EVPL | P9T-E | Human | Esophagus | ESCC | 3.92e-11 | 1.99e-01 | 0.1131 |
2125 | EVPL | P10T-E | Human | Esophagus | ESCC | 7.25e-04 | 5.28e-02 | 0.116 |
2125 | EVPL | P11T-E | Human | Esophagus | ESCC | 3.46e-04 | 4.79e-01 | 0.1426 |
2125 | EVPL | P12T-E | Human | Esophagus | ESCC | 5.11e-17 | 3.12e-01 | 0.1122 |
2125 | EVPL | P15T-E | Human | Esophagus | ESCC | 1.02e-20 | 5.05e-01 | 0.1149 |
2125 | EVPL | P16T-E | Human | Esophagus | ESCC | 1.14e-04 | 2.28e-02 | 0.1153 |
2125 | EVPL | P20T-E | Human | Esophagus | ESCC | 6.59e-49 | 1.01e+00 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00435888 | Esophagus | ESCC | skin development | 163/8552 | 263/18723 | 6.48e-08 | 1.14e-06 | 163 |
GO:000854410 | Esophagus | ESCC | epidermis development | 193/8552 | 324/18723 | 2.87e-07 | 4.19e-06 | 193 |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:000991310 | Esophagus | ESCC | epidermal cell differentiation | 122/8552 | 202/18723 | 1.69e-05 | 1.51e-04 | 122 |
GO:00302167 | Esophagus | ESCC | keratinocyte differentiation | 86/8552 | 139/18723 | 8.53e-05 | 6.19e-04 | 86 |
GO:00451035 | Esophagus | ESCC | intermediate filament-based process | 32/8552 | 52/18723 | 1.55e-02 | 4.97e-02 | 32 |
GO:004206020 | Oral cavity | OSCC | wound healing | 237/7305 | 422/18723 | 4.51e-13 | 2.18e-11 | 237 |
GO:00435887 | Oral cavity | OSCC | skin development | 143/7305 | 263/18723 | 2.77e-07 | 4.27e-06 | 143 |
GO:00085449 | Oral cavity | OSCC | epidermis development | 171/7305 | 324/18723 | 2.89e-07 | 4.43e-06 | 171 |
GO:00302166 | Oral cavity | OSCC | keratinocyte differentiation | 81/7305 | 139/18723 | 3.16e-06 | 3.81e-05 | 81 |
GO:00099139 | Oral cavity | OSCC | epidermal cell differentiation | 109/7305 | 202/18723 | 1.08e-05 | 1.14e-04 | 109 |
GO:00451044 | Oral cavity | OSCC | intermediate filament cytoskeleton organization | 31/7305 | 51/18723 | 1.34e-03 | 6.62e-03 | 31 |
GO:00451034 | Oral cavity | OSCC | intermediate filament-based process | 31/7305 | 52/18723 | 2.08e-03 | 9.59e-03 | 31 |
GO:000854416 | Oral cavity | LP | epidermis development | 112/4623 | 324/18723 | 3.81e-05 | 5.61e-04 | 112 |
GO:004358816 | Oral cavity | LP | skin development | 93/4623 | 263/18723 | 6.47e-05 | 8.70e-04 | 93 |
GO:0042060110 | Oral cavity | LP | wound healing | 139/4623 | 422/18723 | 7.10e-05 | 9.48e-04 | 139 |
GO:003021613 | Oral cavity | LP | keratinocyte differentiation | 51/4623 | 139/18723 | 1.05e-03 | 8.84e-03 | 51 |
GO:000991315 | Oral cavity | LP | epidermal cell differentiation | 69/4623 | 202/18723 | 1.53e-03 | 1.19e-02 | 69 |
GO:000854417 | Skin | AK | epidermis development | 79/1910 | 324/18723 | 1.04e-13 | 3.25e-11 | 79 |
GO:00435889 | Skin | AK | skin development | 67/1910 | 263/18723 | 9.02e-13 | 2.14e-10 | 67 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EVPL | SNV | Missense_Mutation | rs774789564 | c.1363N>A | p.Gly455Arg | p.G455R | protein_coding | deleterious(0.02) | benign(0.249) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
EVPL | SNV | Missense_Mutation | rs764730730 | c.4273C>T | p.Arg1425Cys | p.R1425C | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
EVPL | SNV | Missense_Mutation | c.1458N>T | p.Gln486His | p.Q486H | protein_coding | tolerated(0.08) | possibly_damaging(0.885) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
EVPL | SNV | Missense_Mutation | c.5081G>A | p.Ser1694Asn | p.S1694N | protein_coding | tolerated(0.72) | benign(0.005) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
EVPL | SNV | Missense_Mutation | c.4351C>A | p.Arg1451Ser | p.R1451S | protein_coding | tolerated(0.06) | possibly_damaging(0.838) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EVPL | SNV | Missense_Mutation | rs200465568 | c.5372N>A | p.Gly1791Asp | p.G1791D | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EVPL | SNV | Missense_Mutation | rs373207880 | c.3943N>T | p.Arg1315Cys | p.R1315C | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EVPL | SNV | Missense_Mutation | novel | c.4913N>G | p.Glu1638Gly | p.E1638G | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-QG-A5YX-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
EVPL | SNV | Missense_Mutation | c.2516N>T | p.Ala839Val | p.A839V | protein_coding | tolerated(0.95) | benign(0.069) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
EVPL | SNV | Missense_Mutation | novel | c.4483N>T | p.Asp1495Tyr | p.D1495Y | protein_coding | deleterious(0.03) | possibly_damaging(0.459) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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