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Gene: EVL |
Gene summary for EVL |
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Gene information | Species | Human | Gene symbol | EVL | Gene ID | 51466 |
Gene name | Enah/Vasp-like | |
Gene Alias | RNB6 | |
Cytomap | 14q32.2 | |
Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | A0A024R6K5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51466 | EVL | GSM4909293 | Human | Breast | IDC | 2.67e-07 | 2.40e-01 | 0.1581 |
51466 | EVL | GSM4909296 | Human | Breast | IDC | 2.10e-02 | 2.13e-01 | 0.1524 |
51466 | EVL | GSM4909297 | Human | Breast | IDC | 8.52e-16 | 5.53e-01 | 0.1517 |
51466 | EVL | GSM4909301 | Human | Breast | IDC | 1.36e-09 | 4.02e-01 | 0.1577 |
51466 | EVL | GSM4909302 | Human | Breast | IDC | 2.60e-49 | 1.03e+00 | 0.1545 |
51466 | EVL | GSM4909303 | Human | Breast | IDC | 7.33e-07 | 5.84e-01 | 0.0438 |
51466 | EVL | GSM4909304 | Human | Breast | IDC | 1.40e-05 | 2.75e-01 | 0.1636 |
51466 | EVL | GSM4909305 | Human | Breast | IDC | 5.52e-09 | 4.66e-01 | 0.0436 |
51466 | EVL | GSM4909306 | Human | Breast | IDC | 3.04e-30 | 7.26e-01 | 0.1564 |
51466 | EVL | GSM4909307 | Human | Breast | IDC | 3.22e-27 | 7.02e-01 | 0.1569 |
51466 | EVL | GSM4909308 | Human | Breast | IDC | 2.91e-64 | 9.90e-01 | 0.158 |
51466 | EVL | GSM4909311 | Human | Breast | IDC | 2.94e-20 | 3.87e-01 | 0.1534 |
51466 | EVL | GSM4909312 | Human | Breast | IDC | 5.78e-12 | 4.68e-01 | 0.1552 |
51466 | EVL | GSM4909313 | Human | Breast | IDC | 2.81e-09 | 4.70e-01 | 0.0391 |
51466 | EVL | GSM4909317 | Human | Breast | IDC | 4.98e-19 | 5.45e-01 | 0.1355 |
51466 | EVL | GSM4909319 | Human | Breast | IDC | 7.22e-11 | -1.35e-01 | 0.1563 |
51466 | EVL | GSM4909321 | Human | Breast | IDC | 9.44e-30 | 7.76e-01 | 0.1559 |
51466 | EVL | M1 | Human | Breast | IDC | 2.97e-32 | 8.20e-01 | 0.1577 |
51466 | EVL | M5 | Human | Breast | IDC | 2.79e-12 | 9.47e-01 | 0.1598 |
51466 | EVL | NCCBC2 | Human | Breast | DCIS | 1.75e-12 | 8.57e-01 | 0.1554 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190290514 | Breast | IDC | positive regulation of supramolecular fiber organization | 37/1434 | 209/18723 | 1.33e-06 | 5.75e-05 | 37 |
GO:004325414 | Breast | IDC | regulation of protein-containing complex assembly | 61/1434 | 428/18723 | 1.77e-06 | 7.31e-05 | 61 |
GO:003133414 | Breast | IDC | positive regulation of protein-containing complex assembly | 40/1434 | 237/18723 | 1.77e-06 | 7.31e-05 | 40 |
GO:003297014 | Breast | IDC | regulation of actin filament-based process | 56/1434 | 397/18723 | 6.37e-06 | 1.99e-04 | 56 |
GO:000166714 | Breast | IDC | ameboidal-type cell migration | 64/1434 | 475/18723 | 6.65e-06 | 2.05e-04 | 64 |
GO:190290314 | Breast | IDC | regulation of supramolecular fiber organization | 54/1434 | 383/18723 | 9.40e-06 | 2.66e-04 | 54 |
GO:001063112 | Breast | IDC | epithelial cell migration | 51/1434 | 357/18723 | 1.14e-05 | 3.08e-04 | 51 |
GO:009013212 | Breast | IDC | epithelium migration | 51/1434 | 360/18723 | 1.44e-05 | 3.70e-04 | 51 |
GO:009013012 | Breast | IDC | tissue migration | 51/1434 | 365/18723 | 2.11e-05 | 5.11e-04 | 51 |
GO:001063212 | Breast | IDC | regulation of epithelial cell migration | 43/1434 | 292/18723 | 2.61e-05 | 6.17e-04 | 43 |
GO:003227314 | Breast | IDC | positive regulation of protein polymerization | 25/1434 | 138/18723 | 4.46e-05 | 1.01e-03 | 25 |
GO:005149513 | Breast | IDC | positive regulation of cytoskeleton organization | 35/1434 | 226/18723 | 5.04e-05 | 1.09e-03 | 35 |
GO:003295614 | Breast | IDC | regulation of actin cytoskeleton organization | 48/1434 | 358/18723 | 1.03e-04 | 1.96e-03 | 48 |
GO:005149214 | Breast | IDC | regulation of stress fiber assembly | 18/1434 | 91/18723 | 1.60e-04 | 2.76e-03 | 18 |
GO:00512712 | Breast | IDC | negative regulation of cellular component movement | 48/1434 | 367/18723 | 1.88e-04 | 3.12e-03 | 48 |
GO:000701514 | Breast | IDC | actin filament organization | 55/1434 | 442/18723 | 2.45e-04 | 3.84e-03 | 55 |
GO:20001462 | Breast | IDC | negative regulation of cell motility | 46/1434 | 359/18723 | 4.01e-04 | 5.60e-03 | 46 |
GO:003003814 | Breast | IDC | contractile actin filament bundle assembly | 19/1434 | 106/18723 | 4.05e-04 | 5.60e-03 | 19 |
GO:004314914 | Breast | IDC | stress fiber assembly | 19/1434 | 106/18723 | 4.05e-04 | 5.60e-03 | 19 |
GO:005149611 | Breast | IDC | positive regulation of stress fiber assembly | 12/1434 | 52/18723 | 4.51e-04 | 6.07e-03 | 12 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0401518 | Oral cavity | OSCC | Rap1 signaling pathway | 107/3704 | 210/8465 | 2.01e-02 | 4.34e-02 | 2.21e-02 | 107 |
hsa0401519 | Oral cavity | OSCC | Rap1 signaling pathway | 107/3704 | 210/8465 | 2.01e-02 | 4.34e-02 | 2.21e-02 | 107 |
hsa0401524 | Oral cavity | NEOLP | Rap1 signaling pathway | 40/1112 | 210/8465 | 9.07e-03 | 3.17e-02 | 1.99e-02 | 40 |
hsa0401534 | Oral cavity | NEOLP | Rap1 signaling pathway | 40/1112 | 210/8465 | 9.07e-03 | 3.17e-02 | 1.99e-02 | 40 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EVL | SNV | Missense_Mutation | novel | c.1211N>C | p.Ile404Thr | p.I404T | Q9UI08 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-CG-4477-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
EVL | deletion | Frame_Shift_Del | novel | c.1210delN | p.Ile404SerfsTer9 | p.I404Sfs*9 | Q9UI08 | protein_coding | TCGA-CG-4477-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD | ||
EVL | insertion | Frame_Shift_Ins | rs775182748 | c.558_559insC | p.Pro190ThrfsTer108 | p.P190Tfs*108 | Q9UI08 | protein_coding | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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