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Gene: ESPN |
Gene summary for ESPN |
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Gene information | Species | Human | Gene symbol | ESPN | Gene ID | 83715 |
Gene name | espin | |
Gene Alias | DFNB36 | |
Cytomap | 1p36.31 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | B1AK53 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83715 | ESPN | LZE20T | Human | Esophagus | ESCC | 2.00e-09 | 3.25e-01 | 0.0662 |
83715 | ESPN | LZE22T | Human | Esophagus | ESCC | 5.45e-08 | 5.91e-01 | 0.068 |
83715 | ESPN | LZE24T | Human | Esophagus | ESCC | 2.42e-11 | 2.36e-01 | 0.0596 |
83715 | ESPN | P1T-E | Human | Esophagus | ESCC | 4.47e-05 | 2.97e-01 | 0.0875 |
83715 | ESPN | P2T-E | Human | Esophagus | ESCC | 4.01e-13 | 2.24e-01 | 0.1177 |
83715 | ESPN | P4T-E | Human | Esophagus | ESCC | 4.25e-25 | 5.83e-01 | 0.1323 |
83715 | ESPN | P5T-E | Human | Esophagus | ESCC | 5.59e-03 | 1.36e-01 | 0.1327 |
83715 | ESPN | P8T-E | Human | Esophagus | ESCC | 8.87e-32 | 6.10e-01 | 0.0889 |
83715 | ESPN | P9T-E | Human | Esophagus | ESCC | 1.82e-07 | 7.74e-02 | 0.1131 |
83715 | ESPN | P10T-E | Human | Esophagus | ESCC | 4.00e-11 | 2.30e-01 | 0.116 |
83715 | ESPN | P11T-E | Human | Esophagus | ESCC | 1.92e-03 | 1.76e-01 | 0.1426 |
83715 | ESPN | P12T-E | Human | Esophagus | ESCC | 4.91e-27 | 6.17e-01 | 0.1122 |
83715 | ESPN | P15T-E | Human | Esophagus | ESCC | 2.19e-26 | 4.73e-01 | 0.1149 |
83715 | ESPN | P17T-E | Human | Esophagus | ESCC | 2.09e-04 | 2.53e-01 | 0.1278 |
83715 | ESPN | P20T-E | Human | Esophagus | ESCC | 6.56e-17 | 3.79e-01 | 0.1124 |
83715 | ESPN | P21T-E | Human | Esophagus | ESCC | 3.82e-05 | 1.57e-01 | 0.1617 |
83715 | ESPN | P23T-E | Human | Esophagus | ESCC | 6.32e-14 | 2.80e-01 | 0.108 |
83715 | ESPN | P24T-E | Human | Esophagus | ESCC | 6.68e-09 | 2.35e-01 | 0.1287 |
83715 | ESPN | P26T-E | Human | Esophagus | ESCC | 8.23e-34 | 5.77e-01 | 0.1276 |
83715 | ESPN | P27T-E | Human | Esophagus | ESCC | 3.04e-23 | 4.42e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
GO:005101727 | Esophagus | ESCC | actin filament bundle assembly | 100/8552 | 157/18723 | 3.87e-06 | 4.17e-05 | 100 |
GO:006157227 | Esophagus | ESCC | actin filament bundle organization | 101/8552 | 161/18723 | 9.22e-06 | 8.82e-05 | 101 |
GO:00300339 | Esophagus | ESCC | microvillus assembly | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
GO:000701512 | Liver | Cirrhotic | actin filament organization | 171/4634 | 442/18723 | 3.93e-11 | 2.30e-09 | 171 |
GO:005101712 | Liver | Cirrhotic | actin filament bundle assembly | 69/4634 | 157/18723 | 1.06e-07 | 3.05e-06 | 69 |
GO:006157212 | Liver | Cirrhotic | actin filament bundle organization | 70/4634 | 161/18723 | 1.44e-07 | 3.87e-06 | 70 |
GO:000701522 | Liver | HCC | actin filament organization | 252/7958 | 442/18723 | 3.83e-10 | 1.25e-08 | 252 |
GO:005101722 | Liver | HCC | actin filament bundle assembly | 96/7958 | 157/18723 | 1.81e-06 | 2.52e-05 | 96 |
GO:006157222 | Liver | HCC | actin filament bundle organization | 97/7958 | 161/18723 | 4.04e-06 | 5.22e-05 | 97 |
GO:00325286 | Liver | HCC | microvillus organization | 18/7958 | 24/18723 | 1.27e-03 | 6.92e-03 | 18 |
GO:000701520 | Oral cavity | OSCC | actin filament organization | 230/7305 | 442/18723 | 1.37e-08 | 2.77e-07 | 230 |
GO:005101720 | Oral cavity | OSCC | actin filament bundle assembly | 86/7305 | 157/18723 | 4.28e-05 | 3.70e-04 | 86 |
GO:006157220 | Oral cavity | OSCC | actin filament bundle organization | 87/7305 | 161/18723 | 7.49e-05 | 5.84e-04 | 87 |
GO:0007015110 | Oral cavity | LP | actin filament organization | 143/4623 | 442/18723 | 1.44e-04 | 1.65e-03 | 143 |
GO:0051017110 | Oral cavity | LP | actin filament bundle assembly | 53/4623 | 157/18723 | 6.54e-03 | 3.83e-02 | 53 |
GO:00070156 | Stomach | GC | actin filament organization | 67/1159 | 442/18723 | 7.96e-12 | 2.20e-09 | 67 |
GO:00325285 | Stomach | GC | microvillus organization | 13/1159 | 24/18723 | 2.41e-10 | 3.75e-08 | 13 |
GO:00615726 | Stomach | GC | actin filament bundle organization | 30/1159 | 161/18723 | 5.07e-08 | 3.40e-06 | 30 |
GO:00510176 | Stomach | GC | actin filament bundle assembly | 29/1159 | 157/18723 | 1.03e-07 | 6.28e-06 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ESPN | SNV | Missense_Mutation | rs761979450 | c.2525N>T | p.Arg842Leu | p.R842L | B1AK53 | protein_coding | deleterious(0) | possibly_damaging(0.796) | TCGA-DD-A114-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ESPN | SNV | Missense_Mutation | novel | c.790N>T | p.Gly264Trp | p.G264W | B1AK53 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-DD-AACI-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ESPN | SNV | Missense_Mutation | novel | c.388G>A | p.Asp130Asn | p.D130N | B1AK53 | protein_coding | tolerated(0.19) | benign(0.129) | TCGA-49-6742-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | alimta | PD |
ESPN | SNV | Missense_Mutation | c.1085N>G | p.Ser362Trp | p.S362W | B1AK53 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ESPN | SNV | Missense_Mutation | c.2054N>A | p.Ala685Asp | p.A685D | B1AK53 | protein_coding | deleterious(0.03) | benign(0.103) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ESPN | SNV | Missense_Mutation | novel | c.1111N>T | p.Ser371Cys | p.S371C | B1AK53 | protein_coding | tolerated(0.13) | benign(0.01) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
ESPN | SNV | Missense_Mutation | c.2206G>T | p.Val736Leu | p.V736L | B1AK53 | protein_coding | tolerated(0.15) | possibly_damaging(0.899) | TCGA-39-5027-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ESPN | insertion | Frame_Shift_Ins | novel | c.2537dupT | p.Lys847GlufsTer7 | p.K847Efs*7 | B1AK53 | protein_coding | TCGA-64-1679-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
ESPN | SNV | Missense_Mutation | c.433N>A | p.Ala145Thr | p.A145T | B1AK53 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ESPN | SNV | Missense_Mutation | c.1173N>T | p.Lys391Asn | p.K391N | B1AK53 | protein_coding | deleterious(0.04) | possibly_damaging(0.448) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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