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Gene: EPC1 |
Gene summary for EPC1 |
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Gene information | Species | Human | Gene symbol | EPC1 | Gene ID | 80314 |
Gene name | enhancer of polycomb homolog 1 | |
Gene Alias | Epl1 | |
Cytomap | 10p11.22 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9H2F5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80314 | EPC1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.13e-19 | -6.08e-01 | 0.0155 |
80314 | EPC1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.81e-05 | -4.98e-01 | -0.1808 |
80314 | EPC1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.80e-08 | -5.63e-01 | -0.1207 |
80314 | EPC1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.13e-06 | -3.53e-01 | -0.1464 |
80314 | EPC1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.66e-03 | -3.26e-01 | -0.059 |
80314 | EPC1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.95e-02 | -5.50e-01 | -0.2061 |
80314 | EPC1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.88e-05 | -3.96e-01 | 0.096 |
80314 | EPC1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.72e-04 | -3.74e-01 | 0.0674 |
80314 | EPC1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.84e-04 | -3.75e-01 | 0.3859 |
80314 | EPC1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.23e-05 | -5.48e-01 | 0.2585 |
80314 | EPC1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.02e-16 | -5.23e-01 | 0.3005 |
80314 | EPC1 | F007 | Human | Colorectum | FAP | 9.23e-03 | -2.78e-01 | 0.1176 |
80314 | EPC1 | A001-C-207 | Human | Colorectum | FAP | 2.38e-05 | -2.91e-01 | 0.1278 |
80314 | EPC1 | A015-C-203 | Human | Colorectum | FAP | 2.89e-22 | -3.81e-01 | -0.1294 |
80314 | EPC1 | A015-C-204 | Human | Colorectum | FAP | 4.12e-08 | -3.12e-01 | -0.0228 |
80314 | EPC1 | A014-C-040 | Human | Colorectum | FAP | 4.86e-05 | -2.54e-01 | -0.1184 |
80314 | EPC1 | A002-C-201 | Human | Colorectum | FAP | 1.18e-11 | -2.20e-01 | 0.0324 |
80314 | EPC1 | A002-C-203 | Human | Colorectum | FAP | 2.88e-03 | -1.26e-01 | 0.2786 |
80314 | EPC1 | A001-C-119 | Human | Colorectum | FAP | 3.08e-08 | -3.29e-01 | -0.1557 |
80314 | EPC1 | A001-C-108 | Human | Colorectum | FAP | 8.95e-12 | -2.02e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016570 | Colorectum | MSS | histone modification | 113/3467 | 463/18723 | 8.37e-04 | 8.68e-03 | 113 |
GO:00165701 | Colorectum | FAP | histone modification | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
GO:00165702 | Colorectum | CRC | histone modification | 75/2078 | 463/18723 | 4.95e-04 | 7.06e-03 | 75 |
GO:00182057 | Esophagus | HGIN | peptidyl-lysine modification | 88/2587 | 376/18723 | 2.99e-07 | 1.39e-05 | 88 |
GO:00165708 | Esophagus | HGIN | histone modification | 92/2587 | 463/18723 | 1.70e-04 | 3.30e-03 | 92 |
GO:00064735 | Esophagus | HGIN | protein acetylation | 45/2587 | 201/18723 | 6.17e-04 | 8.58e-03 | 45 |
GO:00183945 | Esophagus | HGIN | peptidyl-lysine acetylation | 39/2587 | 169/18723 | 7.46e-04 | 9.90e-03 | 39 |
GO:00435435 | Esophagus | HGIN | protein acylation | 51/2587 | 243/18723 | 1.33e-03 | 1.57e-02 | 51 |
GO:00439675 | Esophagus | HGIN | histone H4 acetylation | 19/2587 | 67/18723 | 1.39e-03 | 1.63e-02 | 19 |
GO:00064755 | Esophagus | HGIN | internal protein amino acid acetylation | 36/2587 | 160/18723 | 1.87e-03 | 2.01e-02 | 36 |
GO:00183935 | Esophagus | HGIN | internal peptidyl-lysine acetylation | 35/2587 | 158/18723 | 2.82e-03 | 2.75e-02 | 35 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:001839413 | Esophagus | ESCC | peptidyl-lysine acetylation | 123/8552 | 169/18723 | 6.58e-13 | 2.94e-11 | 123 |
GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
GO:000647313 | Esophagus | ESCC | protein acetylation | 140/8552 | 201/18723 | 4.37e-12 | 1.69e-10 | 140 |
GO:001839313 | Esophagus | ESCC | internal peptidyl-lysine acetylation | 114/8552 | 158/18723 | 1.16e-11 | 4.24e-10 | 114 |
GO:000647513 | Esophagus | ESCC | internal protein amino acid acetylation | 115/8552 | 160/18723 | 1.43e-11 | 5.08e-10 | 115 |
GO:00165735 | Esophagus | ESCC | histone acetylation | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:004396712 | Esophagus | ESCC | histone H4 acetylation | 53/8552 | 67/18723 | 2.11e-08 | 4.03e-07 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EPC1 | SNV | Missense_Mutation | novel | c.1175C>A | p.Ala392Asp | p.A392D | Q9H2F5 | protein_coding | tolerated(0.45) | benign(0.368) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EPC1 | SNV | Missense_Mutation | rs143299306 | c.1372N>T | p.Arg458Trp | p.R458W | Q9H2F5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
EPC1 | SNV | Missense_Mutation | novel | c.2191N>C | p.Ser731Pro | p.S731P | Q9H2F5 | protein_coding | tolerated(0.47) | benign(0.003) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EPC1 | SNV | Missense_Mutation | novel | c.1717N>G | p.Lys573Glu | p.K573E | Q9H2F5 | protein_coding | tolerated(1) | benign(0.021) | TCGA-B5-A11J-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EPC1 | SNV | Missense_Mutation | novel | c.2339N>A | p.Thr780Asn | p.T780N | Q9H2F5 | protein_coding | tolerated(0.14) | possibly_damaging(0.642) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EPC1 | SNV | Missense_Mutation | novel | c.640N>T | p.Arg214Cys | p.R214C | Q9H2F5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EPC1 | SNV | Missense_Mutation | novel | c.593N>G | p.Lys198Arg | p.K198R | Q9H2F5 | protein_coding | deleterious(0.03) | benign(0.042) | TCGA-BG-A0VW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EPC1 | SNV | Missense_Mutation | novel | c.2471A>G | p.Asn824Ser | p.N824S | Q9H2F5 | protein_coding | tolerated(0.11) | probably_damaging(0.983) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EPC1 | SNV | Missense_Mutation | c.671G>A | p.Arg224His | p.R224H | Q9H2F5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EPC1 | SNV | Missense_Mutation | novel | c.1402N>T | p.Asp468Tyr | p.D468Y | Q9H2F5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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