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Gene: EOGT |
Gene summary for EOGT |
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Gene information | Species | Human | Gene symbol | EOGT | Gene ID | 285203 |
Gene name | EGF domain specific O-linked N-acetylglucosamine transferase | |
Gene Alias | AER61 | |
Cytomap | 3p14.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q5NDL2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285203 | EOGT | HCC1_Meng | Human | Liver | HCC | 1.64e-08 | 5.23e-03 | 0.0246 |
285203 | EOGT | S014 | Human | Liver | HCC | 1.43e-04 | 2.05e-01 | 0.2254 |
285203 | EOGT | S015 | Human | Liver | HCC | 6.19e-03 | 1.92e-01 | 0.2375 |
285203 | EOGT | S016 | Human | Liver | HCC | 5.75e-03 | 1.74e-01 | 0.2243 |
285203 | EOGT | S027 | Human | Liver | HCC | 1.05e-04 | 4.24e-01 | 0.2446 |
285203 | EOGT | S028 | Human | Liver | HCC | 8.42e-19 | 5.07e-01 | 0.2503 |
285203 | EOGT | S029 | Human | Liver | HCC | 1.02e-20 | 6.37e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064862 | Liver | HCC | protein glycosylation | 122/7958 | 226/18723 | 3.11e-04 | 2.21e-03 | 122 |
GO:00434132 | Liver | HCC | macromolecule glycosylation | 122/7958 | 226/18723 | 3.11e-04 | 2.21e-03 | 122 |
GO:00700852 | Liver | HCC | glycosylation | 128/7958 | 240/18723 | 4.35e-04 | 2.92e-03 | 128 |
GO:001821011 | Liver | HCC | peptidyl-threonine modification | 71/7958 | 125/18723 | 8.68e-04 | 5.14e-03 | 71 |
GO:0009100 | Liver | HCC | glycoprotein metabolic process | 193/7958 | 387/18723 | 1.89e-03 | 9.62e-03 | 193 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EOGT | SNV | Missense_Mutation | rs764559304 | c.1387N>A | p.Val463Ile | p.V463I | Q5NDL2 | protein_coding | tolerated(0.64) | benign(0.023) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EOGT | SNV | Missense_Mutation | novel | c.127N>A | p.Pro43Thr | p.P43T | Q5NDL2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EOGT | SNV | Missense_Mutation | rs587776995 | c.1130G>A | p.Arg377Gln | p.R377Q | Q5NDL2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EOGT | SNV | Missense_Mutation | novel | c.1231N>T | p.Asp411Tyr | p.D411Y | Q5NDL2 | protein_coding | deleterious(0) | possibly_damaging(0.609) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EOGT | SNV | Missense_Mutation | rs767009449 | c.365N>A | p.Gly122Glu | p.G122E | Q5NDL2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EOGT | SNV | Missense_Mutation | novel | c.1090N>C | p.Lys364Gln | p.K364Q | Q5NDL2 | protein_coding | deleterious(0.05) | benign(0.389) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
EOGT | SNV | Missense_Mutation | novel | c.913N>T | p.Asp305Tyr | p.D305Y | Q5NDL2 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
EOGT | SNV | Missense_Mutation | novel | c.905N>C | p.Lys302Thr | p.K302T | Q5NDL2 | protein_coding | deleterious(0.01) | possibly_damaging(0.841) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
EOGT | SNV | Missense_Mutation | novel | c.716N>C | p.Lys239Thr | p.K239T | Q5NDL2 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
EOGT | SNV | Missense_Mutation | novel | c.503N>T | p.Arg168Ile | p.R168I | Q5NDL2 | protein_coding | deleterious(0.01) | benign(0.039) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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