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Gene: ENPP7 |
Gene summary for ENPP7 |
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Gene information | Species | Human | Gene symbol | ENPP7 | Gene ID | 339221 |
Gene name | ectonucleotide pyrophosphatase/phosphodiesterase 7 | |
Gene Alias | ALK-SMase | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q6UWV6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339221 | ENPP7 | Pat01-B | Human | Stomach | GC | 1.32e-16 | 4.20e-01 | 0.5754 |
339221 | ENPP7 | Pat03-B | Human | Stomach | GC | 4.97e-02 | 1.29e-01 | 0.3693 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007586 | Stomach | GC | digestion | 38/1159 | 137/18723 | 1.80e-15 | 1.22e-12 | 38 |
GO:00226006 | Stomach | GC | digestive system process | 30/1159 | 104/18723 | 5.40e-13 | 2.10e-10 | 30 |
GO:00508925 | Stomach | GC | intestinal absorption | 18/1159 | 41/18723 | 8.10e-12 | 2.20e-09 | 18 |
GO:0098856 | Stomach | GC | intestinal lipid absorption | 10/1159 | 21/18723 | 1.50e-07 | 8.56e-06 | 10 |
GO:00442424 | Stomach | GC | cellular lipid catabolic process | 32/1159 | 214/18723 | 3.16e-06 | 1.29e-04 | 32 |
GO:00160425 | Stomach | GC | lipid catabolic process | 41/1159 | 320/18723 | 7.84e-06 | 2.80e-04 | 41 |
GO:00342506 | Stomach | GC | positive regulation of cellular amide metabolic process | 25/1159 | 162/18723 | 2.12e-05 | 6.44e-04 | 25 |
GO:0030299 | Stomach | GC | intestinal cholesterol absorption | 7/1159 | 18/18723 | 5.94e-05 | 1.35e-03 | 7 |
GO:0055088 | Stomach | GC | lipid homeostasis | 24/1159 | 167/18723 | 9.86e-05 | 2.00e-03 | 24 |
GO:00313316 | Stomach | GC | positive regulation of cellular catabolic process | 46/1159 | 427/18723 | 1.79e-04 | 3.12e-03 | 46 |
GO:0044241 | Stomach | GC | lipid digestion | 7/1159 | 21/18723 | 1.84e-04 | 3.16e-03 | 7 |
GO:0019216 | Stomach | GC | regulation of lipid metabolic process | 37/1159 | 331/18723 | 3.67e-04 | 5.70e-03 | 37 |
GO:00098966 | Stomach | GC | positive regulation of catabolic process | 50/1159 | 492/18723 | 3.89e-04 | 5.97e-03 | 50 |
GO:0046890 | Stomach | GC | regulation of lipid biosynthetic process | 22/1159 | 171/18723 | 8.94e-04 | 1.10e-02 | 22 |
GO:0050996 | Stomach | GC | positive regulation of lipid catabolic process | 7/1159 | 28/18723 | 1.28e-03 | 1.44e-02 | 7 |
GO:0030301 | Stomach | GC | cholesterol transport | 16/1159 | 117/18723 | 2.29e-03 | 2.21e-02 | 16 |
GO:0015918 | Stomach | GC | sterol transport | 17/1159 | 130/18723 | 2.75e-03 | 2.53e-02 | 17 |
GO:1904729 | Stomach | GC | regulation of intestinal lipid absorption | 4/1159 | 11/18723 | 3.39e-03 | 2.94e-02 | 4 |
GO:1904478 | Stomach | GC | regulation of intestinal absorption | 4/1159 | 13/18723 | 6.65e-03 | 4.85e-02 | 4 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENPP7 | SNV | Missense_Mutation | novel | c.616N>T | p.Gly206Cys | p.G206C | Q6UWV6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ENPP7 | SNV | Missense_Mutation | novel | c.617N>T | p.Gly206Val | p.G206V | Q6UWV6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ENPP7 | SNV | Missense_Mutation | novel | c.237N>A | p.His79Gln | p.H79Q | Q6UWV6 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-05-4398-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
ENPP7 | SNV | Missense_Mutation | c.751N>T | p.Thr251Ser | p.T251S | Q6UWV6 | protein_coding | deleterious(0.01) | benign(0.03) | TCGA-50-5068-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | taxol | PD | |
ENPP7 | SNV | Missense_Mutation | novel | c.228N>A | p.Ser76Arg | p.S76R | Q6UWV6 | protein_coding | deleterious(0.04) | benign(0.046) | TCGA-55-6969-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ENPP7 | SNV | Missense_Mutation | novel | c.1301C>A | p.Ala434Asp | p.A434D | Q6UWV6 | protein_coding | tolerated_low_confidence(0.35) | benign(0.413) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
ENPP7 | SNV | Missense_Mutation | c.851G>T | p.Gly284Val | p.G284V | Q6UWV6 | protein_coding | deleterious(0) | benign(0.343) | TCGA-78-7166-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ENPP7 | SNV | Missense_Mutation | c.395G>A | p.Arg132Lys | p.R132K | Q6UWV6 | protein_coding | tolerated(0.12) | benign(0.007) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ENPP7 | SNV | Missense_Mutation | rs372623650 | c.764N>A | p.Arg255Gln | p.R255Q | Q6UWV6 | protein_coding | tolerated(0.39) | benign(0) | TCGA-91-6828-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ENPP7 | SNV | Missense_Mutation | c.951N>T | p.Glu317Asp | p.E317D | Q6UWV6 | protein_coding | tolerated(0.06) | benign(0.06) | TCGA-NJ-A4YI-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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