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Gene: EIF4G1 |
Gene summary for EIF4G1 |
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Gene information | Species | Human | Gene symbol | EIF4G1 | Gene ID | 1981 |
Gene name | eukaryotic translation initiation factor 4 gamma 1 | |
Gene Alias | EIF-4G1 | |
Cytomap | 3q27.1 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | B2RU06 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1981 | EIF4G1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.72e-03 | 2.46e-01 | 0.0155 |
1981 | EIF4G1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.80e-16 | 7.48e-01 | -0.1808 |
1981 | EIF4G1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.43e-16 | 7.45e-01 | -0.0811 |
1981 | EIF4G1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.84e-08 | 4.62e-01 | -0.1088 |
1981 | EIF4G1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.03e-28 | 7.71e-01 | -0.1954 |
1981 | EIF4G1 | HTA11_411_2000001011 | Human | Colorectum | SER | 9.45e-06 | 9.53e-01 | -0.2602 |
1981 | EIF4G1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.65e-03 | 7.39e-01 | -0.2196 |
1981 | EIF4G1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.50e-03 | 4.61e-01 | -0.1207 |
1981 | EIF4G1 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.81e-13 | 8.19e-01 | -0.1526 |
1981 | EIF4G1 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.65e-31 | 9.44e-01 | -0.1464 |
1981 | EIF4G1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.23e-12 | 6.39e-01 | -0.1001 |
1981 | EIF4G1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.40e-33 | 1.19e+00 | -0.059 |
1981 | EIF4G1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.64e-04 | 6.38e-01 | -0.1706 |
1981 | EIF4G1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.34e-05 | 5.68e-01 | -0.0842 |
1981 | EIF4G1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.61e-02 | 4.25e-01 | -0.0179 |
1981 | EIF4G1 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.11e-30 | 9.23e-01 | 0.096 |
1981 | EIF4G1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.97e-03 | 6.13e-01 | 0.0446 |
1981 | EIF4G1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.44e-04 | 6.30e-01 | 0.0528 |
1981 | EIF4G1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.23e-14 | 8.92e-01 | 0.0131 |
1981 | EIF4G1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.03e-02 | 4.90e-01 | -0.0177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
GO:0031330 | Colorectum | AD | negative regulation of cellular catabolic process | 104/3918 | 262/18723 | 2.66e-12 | 3.96e-10 | 104 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
GO:0051099 | Colorectum | AD | positive regulation of binding | 66/3918 | 173/18723 | 1.47e-07 | 6.64e-06 | 66 |
GO:0002183 | Colorectum | AD | cytoplasmic translational initiation | 21/3918 | 34/18723 | 2.73e-07 | 1.09e-05 | 21 |
GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0010563 | Colorectum | AD | negative regulation of phosphorus metabolic process | 130/3918 | 442/18723 | 1.26e-05 | 2.76e-04 | 130 |
GO:1901214 | Colorectum | AD | regulation of neuron death | 99/3918 | 319/18723 | 1.26e-05 | 2.76e-04 | 99 |
GO:0006413 | Colorectum | AD | translational initiation | 45/3918 | 118/18723 | 1.35e-05 | 2.92e-04 | 45 |
GO:0045936 | Colorectum | AD | negative regulation of phosphate metabolic process | 129/3918 | 441/18723 | 1.81e-05 | 3.76e-04 | 129 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05416 | Colorectum | MSI-H | Viral myocarditis | 14/797 | 60/8465 | 1.09e-03 | 1.20e-02 | 1.01e-02 | 14 |
hsa054161 | Colorectum | MSI-H | Viral myocarditis | 14/797 | 60/8465 | 1.09e-03 | 1.20e-02 | 1.01e-02 | 14 |
hsa0541630 | Esophagus | ESCC | Viral myocarditis | 41/4205 | 60/8465 | 2.59e-03 | 7.05e-03 | 3.61e-03 | 41 |
hsa05416114 | Esophagus | ESCC | Viral myocarditis | 41/4205 | 60/8465 | 2.59e-03 | 7.05e-03 | 3.61e-03 | 41 |
hsa0541614 | Liver | Cirrhotic | Viral myocarditis | 28/2530 | 60/8465 | 4.38e-03 | 1.68e-02 | 1.03e-02 | 28 |
hsa0541615 | Liver | Cirrhotic | Viral myocarditis | 28/2530 | 60/8465 | 4.38e-03 | 1.68e-02 | 1.03e-02 | 28 |
hsa0541629 | Oral cavity | OSCC | Viral myocarditis | 39/3704 | 60/8465 | 7.13e-04 | 2.09e-03 | 1.07e-03 | 39 |
hsa05416113 | Oral cavity | OSCC | Viral myocarditis | 39/3704 | 60/8465 | 7.13e-04 | 2.09e-03 | 1.07e-03 | 39 |
hsa05416210 | Oral cavity | LP | Viral myocarditis | 32/2418 | 60/8465 | 4.55e-05 | 2.91e-04 | 1.88e-04 | 32 |
hsa0541637 | Oral cavity | LP | Viral myocarditis | 32/2418 | 60/8465 | 4.55e-05 | 2.91e-04 | 1.88e-04 | 32 |
hsa0541662 | Oral cavity | NEOLP | Viral myocarditis | 17/1112 | 60/8465 | 1.38e-03 | 6.45e-03 | 4.06e-03 | 17 |
hsa0541672 | Oral cavity | NEOLP | Viral myocarditis | 17/1112 | 60/8465 | 1.38e-03 | 6.45e-03 | 4.06e-03 | 17 |
hsa0541627 | Prostate | BPH | Viral myocarditis | 23/1718 | 60/8465 | 9.59e-04 | 4.47e-03 | 2.76e-03 | 23 |
hsa05416112 | Prostate | BPH | Viral myocarditis | 23/1718 | 60/8465 | 9.59e-04 | 4.47e-03 | 2.76e-03 | 23 |
hsa0541628 | Prostate | Tumor | Viral myocarditis | 24/1791 | 60/8465 | 6.83e-04 | 3.33e-03 | 2.06e-03 | 24 |
hsa0541636 | Prostate | Tumor | Viral myocarditis | 24/1791 | 60/8465 | 6.83e-04 | 3.33e-03 | 2.06e-03 | 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF4G1 | SNV | Missense_Mutation | rs756664955 | c.3572G>A | p.Arg1191Gln | p.R1191Q | Q04637 | protein_coding | tolerated(0.08) | possibly_damaging(0.768) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
EIF4G1 | SNV | Missense_Mutation | novel | c.134N>A | p.Ser45Tyr | p.S45Y | Q04637 | protein_coding | deleterious(0) | benign(0.125) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
EIF4G1 | SNV | Missense_Mutation | c.2111N>T | p.Ala704Val | p.A704V | Q04637 | protein_coding | tolerated(0.47) | benign(0.343) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EIF4G1 | SNV | Missense_Mutation | c.557N>T | p.Thr186Met | p.T186M | Q04637 | protein_coding | deleterious(0.04) | possibly_damaging(0.513) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EIF4G1 | SNV | Missense_Mutation | c.2698N>T | p.Arg900Trp | p.R900W | Q04637 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EIF4G1 | SNV | Missense_Mutation | rs752416317 | c.689C>T | p.Thr230Met | p.T230M | Q04637 | protein_coding | deleterious(0.02) | benign(0.013) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF4G1 | SNV | Missense_Mutation | c.622N>T | p.Arg208Cys | p.R208C | Q04637 | protein_coding | deleterious(0) | possibly_damaging(0.745) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
EIF4G1 | SNV | Missense_Mutation | c.3817N>A | p.Val1273Met | p.V1273M | Q04637 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD | |
EIF4G1 | SNV | Missense_Mutation | c.3599N>A | p.Arg1200Gln | p.R1200Q | Q04637 | protein_coding | tolerated(0.17) | possibly_damaging(0.536) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EIF4G1 | SNV | Missense_Mutation | c.1224N>T | p.Glu408Asp | p.E408D | Q04637 | protein_coding | deleterious(0.04) | probably_damaging(0.931) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1981 | EIF4G1 | NA | INSULIN | INSULIN | 8521827 |
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