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Gene: EGR4 |
Gene summary for EGR4 |
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Gene information | Species | Human | Gene symbol | EGR4 | Gene ID | 1961 |
Gene name | early growth response 4 | |
Gene Alias | AT133 | |
Cytomap | 2p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B7ZKU3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1961 | EGR4 | P4T-E | Human | Esophagus | ESCC | 1.94e-08 | 6.55e-01 | 0.1323 |
1961 | EGR4 | P5T-E | Human | Esophagus | ESCC | 1.75e-25 | 1.17e+00 | 0.1327 |
1961 | EGR4 | P10T-E | Human | Esophagus | ESCC | 2.06e-08 | 3.23e-01 | 0.116 |
1961 | EGR4 | P12T-E | Human | Esophagus | ESCC | 7.98e-13 | 3.44e-01 | 0.1122 |
1961 | EGR4 | P16T-E | Human | Esophagus | ESCC | 1.76e-12 | 5.92e-01 | 0.1153 |
1961 | EGR4 | P20T-E | Human | Esophagus | ESCC | 2.67e-29 | 1.86e+00 | 0.1124 |
1961 | EGR4 | P22T-E | Human | Esophagus | ESCC | 4.40e-09 | 4.73e-01 | 0.1236 |
1961 | EGR4 | P23T-E | Human | Esophagus | ESCC | 9.75e-13 | 1.07e+00 | 0.108 |
1961 | EGR4 | P26T-E | Human | Esophagus | ESCC | 8.56e-12 | 4.38e-01 | 0.1276 |
1961 | EGR4 | P27T-E | Human | Esophagus | ESCC | 8.40e-04 | 2.54e-01 | 0.1055 |
1961 | EGR4 | P31T-E | Human | Esophagus | ESCC | 2.03e-09 | 1.95e-01 | 0.1251 |
1961 | EGR4 | P36T-E | Human | Esophagus | ESCC | 1.10e-05 | 5.51e-01 | 0.1187 |
1961 | EGR4 | P39T-E | Human | Esophagus | ESCC | 9.53e-09 | 2.84e-01 | 0.0894 |
1961 | EGR4 | P40T-E | Human | Esophagus | ESCC | 9.65e-05 | 7.29e-01 | 0.109 |
1961 | EGR4 | P47T-E | Human | Esophagus | ESCC | 7.52e-23 | 8.98e-01 | 0.1067 |
1961 | EGR4 | P49T-E | Human | Esophagus | ESCC | 2.95e-07 | 1.76e+00 | 0.1768 |
1961 | EGR4 | P52T-E | Human | Esophagus | ESCC | 4.44e-08 | 3.64e-01 | 0.1555 |
1961 | EGR4 | P56T-E | Human | Esophagus | ESCC | 1.41e-02 | 2.37e-01 | 0.1613 |
1961 | EGR4 | P61T-E | Human | Esophagus | ESCC | 3.96e-03 | 3.29e-01 | 0.099 |
1961 | EGR4 | P62T-E | Human | Esophagus | ESCC | 4.14e-47 | 2.00e+00 | 0.1302 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EGR4 | SNV | Missense_Mutation | novel | c.509N>C | p.Cys170Ser | p.C170S | Q05215 | protein_coding | tolerated(0.19) | benign(0.026) | TCGA-2Y-A9HB-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EGR4 | SNV | Missense_Mutation | novel | c.50N>C | p.Leu17Pro | p.L17P | Q05215 | protein_coding | deleterious_low_confidence(0) | benign(0.029) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
EGR4 | SNV | Missense_Mutation | novel | c.887C>T | p.Pro296Leu | p.P296L | Q05215 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-G3-A5SI-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD |
EGR4 | SNV | Missense_Mutation | c.1571N>A | p.Arg524His | p.R524H | Q05215 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-05-4425-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
EGR4 | SNV | Missense_Mutation | novel | c.1645N>A | p.Arg549Ser | p.R549S | Q05215 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-50-6594-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
EGR4 | SNV | Missense_Mutation | c.1111N>T | p.Ala371Ser | p.A371S | Q05215 | protein_coding | tolerated(0.31) | benign(0.025) | TCGA-55-8514-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EGR4 | SNV | Missense_Mutation | novel | c.872N>A | p.Ala291Glu | p.A291E | Q05215 | protein_coding | deleterious(0.04) | probably_damaging(0.987) | TCGA-MP-A4T7-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
EGR4 | SNV | Missense_Mutation | novel | c.1132N>T | p.Asp378Tyr | p.D378Y | Q05215 | protein_coding | deleterious(0) | benign(0.408) | TCGA-56-A5DS-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EGR4 | SNV | Missense_Mutation | novel | c.1479N>G | p.Ser493Arg | p.S493R | Q05215 | protein_coding | tolerated(0.34) | benign(0.015) | TCGA-77-8009-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
EGR4 | SNV | Missense_Mutation | novel | c.895N>A | p.Asp299Asn | p.D299N | Q05215 | protein_coding | deleterious(0) | benign(0.003) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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