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Gene: DZIP1L |
Gene summary for DZIP1L |
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Gene information | Species | Human | Gene symbol | DZIP1L | Gene ID | 199221 |
Gene name | DAZ interacting zinc finger protein 1 like | |
Gene Alias | DZIP2 | |
Cytomap | 3q22.3 | |
Gene Type | protein-coding | GO ID | GO:0003002 | UniProtAcc | Q8IYY4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
199221 | DZIP1L | LZE2T | Human | Esophagus | ESCC | 8.11e-03 | 5.03e-01 | 0.082 |
199221 | DZIP1L | LZE4T | Human | Esophagus | ESCC | 9.19e-06 | 2.69e-01 | 0.0811 |
199221 | DZIP1L | LZE7T | Human | Esophagus | ESCC | 4.56e-02 | 1.66e-01 | 0.0667 |
199221 | DZIP1L | P2T-E | Human | Esophagus | ESCC | 3.19e-23 | 3.93e-01 | 0.1177 |
199221 | DZIP1L | P4T-E | Human | Esophagus | ESCC | 2.14e-07 | 1.79e-01 | 0.1323 |
199221 | DZIP1L | P5T-E | Human | Esophagus | ESCC | 2.03e-09 | 1.95e-01 | 0.1327 |
199221 | DZIP1L | P9T-E | Human | Esophagus | ESCC | 6.56e-16 | 3.68e-01 | 0.1131 |
199221 | DZIP1L | P10T-E | Human | Esophagus | ESCC | 5.95e-29 | 5.27e-01 | 0.116 |
199221 | DZIP1L | P11T-E | Human | Esophagus | ESCC | 4.36e-04 | 1.81e-01 | 0.1426 |
199221 | DZIP1L | P12T-E | Human | Esophagus | ESCC | 8.40e-04 | 9.69e-02 | 0.1122 |
199221 | DZIP1L | P15T-E | Human | Esophagus | ESCC | 1.45e-20 | 5.67e-01 | 0.1149 |
199221 | DZIP1L | P16T-E | Human | Esophagus | ESCC | 5.86e-08 | 1.43e-01 | 0.1153 |
199221 | DZIP1L | P20T-E | Human | Esophagus | ESCC | 9.33e-13 | 3.63e-01 | 0.1124 |
199221 | DZIP1L | P21T-E | Human | Esophagus | ESCC | 3.97e-04 | 8.19e-02 | 0.1617 |
199221 | DZIP1L | P22T-E | Human | Esophagus | ESCC | 4.16e-22 | 3.71e-01 | 0.1236 |
199221 | DZIP1L | P23T-E | Human | Esophagus | ESCC | 2.28e-04 | 1.60e-01 | 0.108 |
199221 | DZIP1L | P24T-E | Human | Esophagus | ESCC | 4.40e-09 | 2.18e-01 | 0.1287 |
199221 | DZIP1L | P27T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.35e-01 | 0.1055 |
199221 | DZIP1L | P28T-E | Human | Esophagus | ESCC | 1.62e-13 | 2.49e-01 | 0.1149 |
199221 | DZIP1L | P30T-E | Human | Esophagus | ESCC | 8.25e-24 | 7.53e-01 | 0.137 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00219159 | Esophagus | ESCC | neural tube development | 101/8552 | 152/18723 | 1.78e-07 | 2.79e-06 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DZIP1L | deletion | Frame_Shift_Del | c.1927delN | p.Arg643GlyfsTer40 | p.R643Gfs*40 | Q8IYY4 | protein_coding | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
DZIP1L | deletion | Frame_Shift_Del | c.1927delC | p.Arg643GlyfsTer40 | p.R643Gfs*40 | Q8IYY4 | protein_coding | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
DZIP1L | SNV | Missense_Mutation | novel | c.155N>C | p.Val52Ala | p.V52A | Q8IYY4 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DZIP1L | SNV | Missense_Mutation | novel | c.2207N>G | p.Gln736Arg | p.Q736R | Q8IYY4 | protein_coding | tolerated(0.12) | benign(0.039) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DZIP1L | SNV | Missense_Mutation | novel | c.1237N>T | p.Ile413Phe | p.I413F | Q8IYY4 | protein_coding | deleterious(0.03) | benign(0.154) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DZIP1L | SNV | Missense_Mutation | rs759170608 | c.134N>A | p.Arg45His | p.R45H | Q8IYY4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
DZIP1L | SNV | Missense_Mutation | c.764G>T | p.Trp255Leu | p.W255L | Q8IYY4 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DZIP1L | SNV | Missense_Mutation | novel | c.1041N>T | p.Glu347Asp | p.E347D | Q8IYY4 | protein_coding | tolerated(0.17) | benign(0.012) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
DZIP1L | SNV | Missense_Mutation | novel | c.1422G>T | p.Lys474Asn | p.K474N | Q8IYY4 | protein_coding | deleterious(0.01) | benign(0.261) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DZIP1L | SNV | Missense_Mutation | novel | c.35N>A | p.Ser12Asn | p.S12N | Q8IYY4 | protein_coding | tolerated(0.25) | benign(0.005) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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