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Gene: DYM |
Gene summary for DYM |
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Gene information | Species | Human | Gene symbol | DYM | Gene ID | 54808 |
Gene name | dymeclin | |
Gene Alias | DMC | |
Cytomap | 18q21.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q7RTS9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54808 | DYM | CCI_1 | Human | Cervix | CC | 1.03e-06 | 7.41e-01 | 0.528 |
54808 | DYM | CCI_2 | Human | Cervix | CC | 1.04e-03 | 4.98e-01 | 0.5249 |
54808 | DYM | CCI_3 | Human | Cervix | CC | 1.23e-08 | 7.15e-01 | 0.516 |
54808 | DYM | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.69e-17 | -6.36e-01 | 0.0155 |
54808 | DYM | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.56e-05 | -3.84e-01 | -0.1808 |
54808 | DYM | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.49e-02 | -6.02e-01 | 0.0216 |
54808 | DYM | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.09e-02 | -5.10e-01 | -0.1207 |
54808 | DYM | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.06e-03 | -4.60e-01 | -0.2061 |
54808 | DYM | HTA11_546_2000001011 | Human | Colorectum | AD | 1.03e-02 | -4.20e-01 | -0.0842 |
54808 | DYM | HTA11_866_3004761011 | Human | Colorectum | AD | 4.75e-09 | -5.23e-01 | 0.096 |
54808 | DYM | HTA11_4255_2000001011 | Human | Colorectum | SER | 8.47e-03 | -4.24e-01 | 0.0446 |
54808 | DYM | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.24e-03 | -4.69e-01 | 0.0171 |
54808 | DYM | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.65e-02 | -4.31e-01 | 0.0338 |
54808 | DYM | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.37e-06 | -4.12e-01 | 0.0674 |
54808 | DYM | HTA11_6818_2000001011 | Human | Colorectum | AD | 6.65e-04 | -4.04e-01 | 0.0112 |
54808 | DYM | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.36e-04 | -4.49e-01 | 0.0588 |
54808 | DYM | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.17e-07 | -3.61e-01 | 0.294 |
54808 | DYM | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.27e-06 | -4.27e-01 | 0.3859 |
54808 | DYM | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.92e-06 | -6.43e-01 | 0.2585 |
54808 | DYM | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.32e-16 | -5.63e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070304 | Cervix | CC | Golgi organization | 32/2311 | 157/18723 | 2.78e-03 | 1.87e-02 | 32 |
GO:0060348 | Colorectum | CRC | bone development | 37/2078 | 205/18723 | 1.96e-03 | 1.96e-02 | 37 |
GO:00070305 | Endometrium | AEH | Golgi organization | 32/2100 | 157/18723 | 5.73e-04 | 5.69e-03 | 32 |
GO:000703012 | Endometrium | EEC | Golgi organization | 32/2168 | 157/18723 | 9.87e-04 | 8.76e-03 | 32 |
GO:00070308 | Esophagus | ESCC | Golgi organization | 101/8552 | 157/18723 | 1.78e-06 | 2.10e-05 | 101 |
GO:00603485 | Esophagus | ESCC | bone development | 115/8552 | 205/18723 | 1.67e-03 | 7.72e-03 | 115 |
GO:0007030 | Liver | NAFLD | Golgi organization | 36/1882 | 157/18723 | 1.76e-06 | 7.68e-05 | 36 |
GO:00603481 | Liver | NAFLD | bone development | 33/1882 | 205/18723 | 4.45e-03 | 3.60e-02 | 33 |
GO:00070301 | Liver | Cirrhotic | Golgi organization | 68/4634 | 157/18723 | 2.57e-07 | 6.41e-06 | 68 |
GO:00070302 | Liver | HCC | Golgi organization | 99/7958 | 157/18723 | 1.54e-07 | 2.85e-06 | 99 |
GO:00070303 | Lung | IAC | Golgi organization | 32/2061 | 157/18723 | 4.13e-04 | 6.22e-03 | 32 |
GO:000703011 | Lung | AIS | Golgi organization | 30/1849 | 157/18723 | 3.09e-04 | 5.63e-03 | 30 |
GO:000703021 | Lung | MIAC | Golgi organization | 18/967 | 157/18723 | 1.27e-03 | 2.37e-02 | 18 |
GO:00070307 | Oral cavity | OSCC | Golgi organization | 92/7305 | 157/18723 | 4.96e-07 | 7.27e-06 | 92 |
GO:00603484 | Oral cavity | OSCC | bone development | 99/7305 | 205/18723 | 4.13e-03 | 1.68e-02 | 99 |
GO:000703014 | Oral cavity | EOLP | Golgi organization | 37/2218 | 157/18723 | 2.83e-05 | 4.12e-04 | 37 |
GO:006034812 | Oral cavity | EOLP | bone development | 37/2218 | 205/18723 | 5.84e-03 | 2.95e-02 | 37 |
GO:006034821 | Oral cavity | NEOLP | bone development | 38/2005 | 205/18723 | 5.28e-04 | 4.64e-03 | 38 |
GO:000703022 | Oral cavity | NEOLP | Golgi organization | 29/2005 | 157/18723 | 2.40e-03 | 1.53e-02 | 29 |
GO:00603483 | Prostate | BPH | bone development | 50/3107 | 205/18723 | 2.60e-03 | 1.39e-02 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DYM | SNV | Missense_Mutation | c.1915T>G | p.Phe639Val | p.F639V | Q7RTS9 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DYM | SNV | Missense_Mutation | rs758432311 | c.1423N>T | p.Arg475Cys | p.R475C | Q7RTS9 | protein_coding | deleterious(0.04) | probably_damaging(0.971) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DYM | SNV | Missense_Mutation | rs202085847 | c.209N>A | p.Arg70Gln | p.R70Q | Q7RTS9 | protein_coding | tolerated(0.41) | benign(0.06) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DYM | SNV | Missense_Mutation | novel | c.1787N>A | p.Ala596Asp | p.A596D | Q7RTS9 | protein_coding | tolerated(0.2) | benign(0.328) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
DYM | SNV | Missense_Mutation | rs202085847 | c.209N>A | p.Arg70Gln | p.R70Q | Q7RTS9 | protein_coding | tolerated(0.41) | benign(0.06) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
DYM | SNV | Missense_Mutation | rs202085847 | c.209N>A | p.Arg70Gln | p.R70Q | Q7RTS9 | protein_coding | tolerated(0.41) | benign(0.06) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DYM | SNV | Missense_Mutation | rs202085847 | c.209N>A | p.Arg70Gln | p.R70Q | Q7RTS9 | protein_coding | tolerated(0.41) | benign(0.06) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
DYM | SNV | Missense_Mutation | rs202085847 | c.209N>A | p.Arg70Gln | p.R70Q | Q7RTS9 | protein_coding | tolerated(0.41) | benign(0.06) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DYM | SNV | Missense_Mutation | rs202085847 | c.209N>A | p.Arg70Gln | p.R70Q | Q7RTS9 | protein_coding | tolerated(0.41) | benign(0.06) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DYM | SNV | Missense_Mutation | novel | c.1012N>T | p.Ala338Ser | p.A338S | Q7RTS9 | protein_coding | deleterious(0.04) | benign(0.005) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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