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Gene: DTNA |
Gene summary for DTNA |
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Gene information | Species | Human | Gene symbol | DTNA | Gene ID | 1837 |
Gene name | dystrobrevin alpha | |
Gene Alias | D18S892E | |
Cytomap | 18q12.1 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9Y4J8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1837 | DTNA | NAFLD1 | Human | Liver | NAFLD | 2.33e-04 | 8.72e-01 | -0.04 |
1837 | DTNA | HCC1_Meng | Human | Liver | HCC | 2.20e-44 | 2.84e-02 | 0.0246 |
1837 | DTNA | cirrhotic3 | Human | Liver | Cirrhotic | 1.60e-04 | 3.81e-02 | 0.0215 |
1837 | DTNA | HCC2 | Human | Liver | HCC | 2.68e-12 | 3.53e+00 | 0.5341 |
1837 | DTNA | Pt13.b | Human | Liver | HCC | 3.17e-07 | 2.43e-02 | 0.0251 |
1837 | DTNA | Pt14.a | Human | Liver | HCC | 2.82e-06 | 3.47e-01 | 0.0169 |
1837 | DTNA | Pt14.b | Human | Liver | HCC | 1.76e-05 | 2.20e-01 | 0.018 |
1837 | DTNA | S016 | Human | Liver | HCC | 1.41e-02 | 2.04e-02 | 0.2243 |
1837 | DTNA | S027 | Human | Liver | HCC | 4.05e-05 | 7.82e-01 | 0.2446 |
1837 | DTNA | S028 | Human | Liver | HCC | 8.49e-27 | 1.11e+00 | 0.2503 |
1837 | DTNA | S029 | Human | Liver | HCC | 6.54e-19 | 9.42e-01 | 0.2581 |
1837 | DTNA | RNA-P17T-P17T-2 | Human | Lung | IAC | 5.30e-08 | 7.78e-01 | 0.3371 |
1837 | DTNA | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.13e-06 | 6.03e-01 | 0.343 |
1837 | DTNA | RNA-P17T-P17T-6 | Human | Lung | IAC | 2.66e-08 | 7.39e-01 | 0.3385 |
1837 | DTNA | RNA-P17T-P17T-8 | Human | Lung | IAC | 5.44e-06 | 7.25e-01 | 0.3329 |
1837 | DTNA | HTA12-15-2 | Human | Pancreas | PDAC | 4.79e-02 | 3.65e-01 | 0.2315 |
1837 | DTNA | HTA12-23-1 | Human | Pancreas | PDAC | 4.29e-05 | 7.29e-01 | 0.3405 |
1837 | DTNA | HTA12-25-1 | Human | Pancreas | PDAC | 1.23e-05 | 7.27e-01 | 0.313 |
1837 | DTNA | HTA12-26-1 | Human | Pancreas | PDAC | 8.94e-13 | 7.89e-01 | 0.3728 |
1837 | DTNA | HTA12-29-1 | Human | Pancreas | PDAC | 1.81e-31 | 8.33e-01 | 0.3722 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00030124 | Lung | IAC | muscle system process | 71/2061 | 452/18723 | 1.29e-03 | 1.45e-02 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DTNA | SNV | Missense_Mutation | novel | c.1561N>A | p.Ser521Thr | p.S521T | Q9Y4J8 | protein_coding | deleterious(0.02) | probably_damaging(0.986) | TCGA-AX-A3FV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DTNA | SNV | Missense_Mutation | novel | c.523C>A | p.Leu175Ile | p.L175I | Q9Y4J8 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DTNA | SNV | Missense_Mutation | novel | c.1292N>G | p.Gln431Arg | p.Q431R | Q9Y4J8 | protein_coding | tolerated(0.08) | benign(0.138) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
DTNA | SNV | Missense_Mutation | novel | c.409G>A | p.Ala137Thr | p.A137T | Q9Y4J8 | protein_coding | deleterious(0.01) | possibly_damaging(0.673) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DTNA | SNV | Missense_Mutation | rs376007740 | c.497G>A | p.Arg166Gln | p.R166Q | Q9Y4J8 | protein_coding | tolerated(0.22) | benign(0.207) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DTNA | SNV | Missense_Mutation | rs756912252 | c.995A>G | p.His332Arg | p.H332R | Q9Y4J8 | protein_coding | deleterious(0.04) | probably_damaging(0.987) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DTNA | SNV | Missense_Mutation | c.1322N>T | p.Ser441Phe | p.S441F | Q9Y4J8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DTNA | SNV | Missense_Mutation | c.79N>A | p.Leu27Met | p.L27M | Q9Y4J8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
DTNA | SNV | Missense_Mutation | c.1609N>T | p.Val537Leu | p.V537L | Q9Y4J8 | protein_coding | tolerated(0.09) | probably_damaging(0.981) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
DTNA | SNV | Missense_Mutation | c.1465C>A | p.Leu489Ile | p.L489I | Q9Y4J8 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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