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Gene: DOCK3 |
Gene summary for DOCK3 |
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Gene information | Species | Human | Gene symbol | DOCK3 | Gene ID | 1795 |
Gene name | dedicator of cytokinesis 3 | |
Gene Alias | MOCA | |
Cytomap | 3p21.2 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q8IZD9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1795 | DOCK3 | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.55e-04 | 5.81e-01 | 0.3329 |
1795 | DOCK3 | RNA-P3T-P3T-4 | Human | Lung | IAC | 2.14e-03 | 3.49e-01 | 0.1859 |
1795 | DOCK3 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 4.21e-10 | 8.16e-01 | -0.0961 |
1795 | DOCK3 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 8.10e-12 | 8.04e-01 | -0.0876 |
1795 | DOCK3 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 7.13e-10 | 8.23e-01 | -0.0822 |
1795 | DOCK3 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 1.02e-08 | 6.30e-01 | -0.0809 |
1795 | DOCK3 | male-WTA | Human | Thyroid | PTC | 3.97e-19 | 1.69e-01 | 0.1037 |
1795 | DOCK3 | PTC01 | Human | Thyroid | PTC | 7.42e-12 | 7.18e-02 | 0.1899 |
1795 | DOCK3 | PTC03 | Human | Thyroid | PTC | 1.05e-09 | 3.40e-01 | 0.1784 |
1795 | DOCK3 | PTC04 | Human | Thyroid | PTC | 4.05e-10 | 1.53e-01 | 0.1927 |
1795 | DOCK3 | PTC05 | Human | Thyroid | PTC | 3.40e-16 | 5.12e-01 | 0.2065 |
1795 | DOCK3 | PTC06 | Human | Thyroid | PTC | 7.47e-28 | 7.49e-01 | 0.2057 |
1795 | DOCK3 | PTC07 | Human | Thyroid | PTC | 8.20e-16 | 2.57e-01 | 0.2044 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510565 | Lung | IAC | regulation of small GTPase mediated signal transduction | 70/2061 | 302/18723 | 9.44e-10 | 1.87e-07 | 70 |
GO:00458607 | Lung | IAC | positive regulation of protein kinase activity | 72/2061 | 386/18723 | 4.89e-06 | 1.96e-04 | 72 |
GO:00336748 | Lung | IAC | positive regulation of kinase activity | 83/2061 | 467/18723 | 6.76e-06 | 2.45e-04 | 83 |
GO:005105611 | Lung | AIS | regulation of small GTPase mediated signal transduction | 66/1849 | 302/18723 | 4.26e-10 | 9.53e-08 | 66 |
GO:003367412 | Lung | AIS | positive regulation of kinase activity | 77/1849 | 467/18723 | 4.67e-06 | 2.31e-04 | 77 |
GO:004586012 | Lung | AIS | positive regulation of protein kinase activity | 65/1849 | 386/18723 | 1.27e-05 | 4.78e-04 | 65 |
GO:0018212 | Lung | AIS | peptidyl-tyrosine modification | 56/1849 | 378/18723 | 1.35e-03 | 1.68e-02 | 56 |
GO:0018108 | Lung | AIS | peptidyl-tyrosine phosphorylation | 55/1849 | 375/18723 | 1.87e-03 | 2.08e-02 | 55 |
GO:0045860111 | Thyroid | PTC | positive regulation of protein kinase activity | 176/5968 | 386/18723 | 8.89e-09 | 2.17e-07 | 176 |
GO:0033674111 | Thyroid | PTC | positive regulation of kinase activity | 201/5968 | 467/18723 | 1.95e-07 | 3.54e-06 | 201 |
GO:005105617 | Thyroid | PTC | regulation of small GTPase mediated signal transduction | 132/5968 | 302/18723 | 9.26e-06 | 1.04e-04 | 132 |
GO:00610974 | Thyroid | PTC | regulation of protein tyrosine kinase activity | 45/5968 | 90/18723 | 2.57e-04 | 1.84e-03 | 45 |
GO:00182126 | Thyroid | PTC | peptidyl-tyrosine modification | 142/5968 | 378/18723 | 1.02e-02 | 4.14e-02 | 142 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DOCK3 | SNV | Missense_Mutation | c.5503N>A | p.His1835Asn | p.H1835N | Q8IZD9 | protein_coding | tolerated_low_confidence(0.21) | benign(0.023) | TCGA-4T-AA8H-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DOCK3 | SNV | Missense_Mutation | c.5145N>T | p.Gln1715His | p.Q1715H | Q8IZD9 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.541) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DOCK3 | SNV | Missense_Mutation | rs752734538 | c.1888C>T | p.Arg630Trp | p.R630W | Q8IZD9 | protein_coding | deleterious(0.02) | possibly_damaging(0.836) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
DOCK3 | SNV | Missense_Mutation | c.2794N>T | p.Arg932Trp | p.R932W | Q8IZD9 | protein_coding | deleterious(0) | benign(0.193) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DOCK3 | SNV | Missense_Mutation | c.1304G>A | p.Arg435Lys | p.R435K | Q8IZD9 | protein_coding | tolerated(0.78) | benign(0.124) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
DOCK3 | SNV | Missense_Mutation | rs773719061 | c.2555N>A | p.Arg852His | p.R852H | Q8IZD9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DOCK3 | SNV | Missense_Mutation | novel | c.695A>G | p.Asp232Gly | p.D232G | Q8IZD9 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DOCK3 | SNV | Missense_Mutation | rs766088466 | c.2780C>T | p.Ala927Val | p.A927V | Q8IZD9 | protein_coding | tolerated(0.05) | benign(0.154) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DOCK3 | SNV | Missense_Mutation | c.4123T>C | p.Cys1375Arg | p.C1375R | Q8IZD9 | protein_coding | deleterious(0.02) | benign(0.418) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DOCK3 | SNV | Missense_Mutation | rs587776362 | c.1153N>T | p.Arg385Cys | p.R385C | Q8IZD9 | protein_coding | deleterious(0.01) | possibly_damaging(0.677) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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