GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001021217 | Esophagus | ESCC | response to ionizing radiation | 110/8552 | 148/18723 | 1.11e-12 | 4.78e-11 | 110 |
GO:0031667111 | Esophagus | ESCC | response to nutrient levels | 289/8552 | 474/18723 | 9.25e-12 | 3.47e-10 | 289 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:0070482111 | Esophagus | ESCC | response to oxygen levels | 218/8552 | 347/18723 | 6.91e-11 | 2.17e-09 | 218 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:0036293111 | Esophagus | ESCC | response to decreased oxygen levels | 201/8552 | 322/18723 | 8.37e-10 | 2.04e-08 | 201 |
GO:0001666111 | Esophagus | ESCC | response to hypoxia | 192/8552 | 307/18723 | 1.59e-09 | 3.69e-08 | 192 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:000758410 | Esophagus | ESCC | response to nutrient | 114/8552 | 174/18723 | 9.43e-08 | 1.56e-06 | 114 |
GO:00400295 | Esophagus | ESCC | regulation of gene expression, epigenetic | 74/8552 | 105/18723 | 2.24e-07 | 3.42e-06 | 74 |
GO:000756820 | Esophagus | ESCC | aging | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:0071453110 | Esophagus | ESCC | cellular response to oxygen levels | 114/8552 | 177/18723 | 3.63e-07 | 5.06e-06 | 114 |
GO:0036294110 | Esophagus | ESCC | cellular response to decreased oxygen levels | 105/8552 | 161/18723 | 4.20e-07 | 5.73e-06 | 105 |
GO:007145616 | Esophagus | ESCC | cellular response to hypoxia | 97/8552 | 151/18723 | 3.12e-06 | 3.51e-05 | 97 |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
GO:001003827 | Esophagus | ESCC | response to metal ion | 208/8552 | 373/18723 | 5.02e-05 | 3.90e-04 | 208 |
GO:00432007 | Esophagus | ESCC | response to amino acid | 74/8552 | 116/18723 | 6.23e-05 | 4.76e-04 | 74 |
GO:000110110 | Esophagus | ESCC | response to acid chemical | 84/8552 | 135/18723 | 7.70e-05 | 5.74e-04 | 84 |
GO:000963620 | Esophagus | ESCC | response to toxic substance | 150/8552 | 262/18723 | 1.00e-04 | 7.12e-04 | 150 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNMT3A | SNV | Missense_Mutation | novel | c.1090N>G | p.Met364Val | p.M364V | Q9Y6K1 | protein_coding | tolerated(0.75) | benign(0.001) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNMT3A | SNV | Missense_Mutation | novel | c.625N>T | p.Arg209Cys | p.R209C | Q9Y6K1 | protein_coding | deleterious(0.03) | possibly_damaging(0.551) | TCGA-A5-A0GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DNMT3A | SNV | Missense_Mutation | rs765593136 | c.985N>G | p.Met329Val | p.M329V | Q9Y6K1 | protein_coding | deleterious(0.02) | benign(0.411) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNMT3A | SNV | Missense_Mutation | | c.1373N>A | p.Arg458Gln | p.R458Q | Q9Y6K1 | protein_coding | tolerated(0.07) | benign(0.087) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
DNMT3A | SNV | Missense_Mutation | novel | c.2012N>T | p.Thr671Met | p.T671M | Q9Y6K1 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DNMT3A | SNV | Missense_Mutation | rs34843713 | c.2246N>A | p.Arg749His | p.R749H | Q9Y6K1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DNMT3A | SNV | Missense_Mutation | rs750837407 | c.1139C>T | p.Ala380Val | p.A380V | Q9Y6K1 | protein_coding | deleterious(0.02) | possibly_damaging(0.522) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNMT3A | SNV | Missense_Mutation | novel | c.475N>A | p.Glu159Lys | p.E159K | Q9Y6K1 | protein_coding | tolerated(0.09) | benign(0.011) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DNMT3A | SNV | Missense_Mutation | | c.2729N>T | p.Ala910Val | p.A910V | Q9Y6K1 | protein_coding | deleterious(0) | benign(0.428) | TCGA-AX-A05Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DNMT3A | SNV | Missense_Mutation | rs139293773 | c.2207N>A | p.Arg736His | p.R736H | Q9Y6K1 | protein_coding | tolerated(0.39) | possibly_damaging(0.874) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1788 | DNMT3A | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | | PMID27376512-Compound-MTC-423 | | |
1788 | DNMT3A | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | | N/A | | 21881046,25281355,22490330,21670448 |
1788 | DNMT3A | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | | PMID27376512-Compound-Figure2aExample1 | | |
1788 | DNMT3A | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | | PMID27376512-Compound-Figure3CM | | |
1788 | DNMT3A | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | | PMID27376512-Compound-MTC-427 | | |
1788 | DNMT3A | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | | PMID27376512-Compound-MTC-422 | | |
1788 | DNMT3A | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | | IDARUBICIN | IDARUBICIN | 22081665 |
1788 | DNMT3A | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | | warfarin | WARFARIN | 27740732 |
1788 | DNMT3A | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | | Decitabine | DECITABINE | 27418649 |
1788 | DNMT3A | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | | DECITABINE | DECITABINE | 22124213 |