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Gene: DNAJC11 |
Gene summary for DNAJC11 |
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Gene information | Species | Human | Gene symbol | DNAJC11 | Gene ID | 55735 |
Gene name | DnaJ heat shock protein family (Hsp40) member C11 | |
Gene Alias | dJ126A5.1 | |
Cytomap | 1p36.31 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q9NVH1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55735 | DNAJC11 | LZE4T | Human | Esophagus | ESCC | 1.33e-06 | 1.85e-01 | 0.0811 |
55735 | DNAJC11 | LZE5T | Human | Esophagus | ESCC | 1.58e-03 | 2.52e-01 | 0.0514 |
55735 | DNAJC11 | LZE7T | Human | Esophagus | ESCC | 4.75e-05 | 3.56e-01 | 0.0667 |
55735 | DNAJC11 | LZE8T | Human | Esophagus | ESCC | 5.03e-07 | 1.62e-01 | 0.067 |
55735 | DNAJC11 | LZE20T | Human | Esophagus | ESCC | 3.58e-06 | 1.70e-01 | 0.0662 |
55735 | DNAJC11 | LZE22T | Human | Esophagus | ESCC | 6.40e-03 | 3.35e-01 | 0.068 |
55735 | DNAJC11 | LZE24T | Human | Esophagus | ESCC | 1.26e-12 | 2.64e-01 | 0.0596 |
55735 | DNAJC11 | LZE6T | Human | Esophagus | ESCC | 2.80e-03 | 2.08e-01 | 0.0845 |
55735 | DNAJC11 | P1T-E | Human | Esophagus | ESCC | 5.93e-04 | 2.68e-01 | 0.0875 |
55735 | DNAJC11 | P2T-E | Human | Esophagus | ESCC | 8.20e-19 | 3.15e-01 | 0.1177 |
55735 | DNAJC11 | P4T-E | Human | Esophagus | ESCC | 3.44e-22 | 4.21e-01 | 0.1323 |
55735 | DNAJC11 | P5T-E | Human | Esophagus | ESCC | 7.55e-15 | 2.28e-01 | 0.1327 |
55735 | DNAJC11 | P8T-E | Human | Esophagus | ESCC | 3.39e-13 | 2.31e-01 | 0.0889 |
55735 | DNAJC11 | P9T-E | Human | Esophagus | ESCC | 2.40e-05 | 1.61e-01 | 0.1131 |
55735 | DNAJC11 | P10T-E | Human | Esophagus | ESCC | 3.24e-24 | 3.82e-01 | 0.116 |
55735 | DNAJC11 | P11T-E | Human | Esophagus | ESCC | 9.31e-15 | 3.87e-01 | 0.1426 |
55735 | DNAJC11 | P12T-E | Human | Esophagus | ESCC | 4.88e-15 | 2.44e-01 | 0.1122 |
55735 | DNAJC11 | P15T-E | Human | Esophagus | ESCC | 1.66e-20 | 4.11e-01 | 0.1149 |
55735 | DNAJC11 | P16T-E | Human | Esophagus | ESCC | 8.69e-11 | 2.32e-01 | 0.1153 |
55735 | DNAJC11 | P17T-E | Human | Esophagus | ESCC | 1.77e-08 | 3.45e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000700619 | Esophagus | ESCC | mitochondrial membrane organization | 93/8552 | 116/18723 | 2.16e-14 | 1.11e-12 | 93 |
GO:000700713 | Esophagus | ESCC | inner mitochondrial membrane organization | 31/8552 | 38/18723 | 5.93e-06 | 6.10e-05 | 31 |
GO:00424072 | Esophagus | ESCC | cristae formation | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
GO:00070065 | Liver | Cirrhotic | mitochondrial membrane organization | 57/4634 | 116/18723 | 1.13e-08 | 4.29e-07 | 57 |
GO:00070073 | Liver | Cirrhotic | inner mitochondrial membrane organization | 19/4634 | 38/18723 | 6.75e-04 | 5.06e-03 | 19 |
GO:000700612 | Liver | HCC | mitochondrial membrane organization | 80/7958 | 116/18723 | 7.09e-09 | 1.81e-07 | 80 |
GO:000700711 | Liver | HCC | inner mitochondrial membrane organization | 28/7958 | 38/18723 | 9.60e-05 | 8.34e-04 | 28 |
GO:0042407 | Liver | HCC | cristae formation | 12/7958 | 16/18723 | 8.74e-03 | 3.40e-02 | 12 |
GO:000700610 | Oral cavity | OSCC | mitochondrial membrane organization | 85/7305 | 116/18723 | 6.29e-14 | 3.40e-12 | 85 |
GO:00070075 | Oral cavity | OSCC | inner mitochondrial membrane organization | 27/7305 | 38/18723 | 6.23e-05 | 5.08e-04 | 27 |
GO:00424071 | Oral cavity | OSCC | cristae formation | 12/7305 | 16/18723 | 3.83e-03 | 1.57e-02 | 12 |
GO:0007006110 | Skin | cSCC | mitochondrial membrane organization | 64/4864 | 116/18723 | 2.16e-11 | 1.08e-09 | 64 |
GO:00070077 | Skin | cSCC | inner mitochondrial membrane organization | 24/4864 | 38/18723 | 1.54e-06 | 2.62e-05 | 24 |
GO:00424073 | Skin | cSCC | cristae formation | 9/4864 | 16/18723 | 9.73e-03 | 4.31e-02 | 9 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAJC11 | SNV | Missense_Mutation | rs754043204 | c.743G>A | p.Arg248His | p.R248H | Q9NVH1 | protein_coding | tolerated(0.41) | benign(0.014) | TCGA-64-1676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DNAJC11 | SNV | Missense_Mutation | novel | c.1135N>T | p.His379Tyr | p.H379Y | Q9NVH1 | protein_coding | tolerated(0.08) | benign(0.189) | TCGA-33-4547-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DNAJC11 | SNV | Missense_Mutation | novel | c.949G>T | p.Asp317Tyr | p.D317Y | Q9NVH1 | protein_coding | deleterious(0) | benign(0.081) | TCGA-33-AASI-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | PD |
DNAJC11 | insertion | Frame_Shift_Ins | novel | c.1465_1466insG | p.Thr489SerfsTer28 | p.T489Sfs*28 | Q9NVH1 | protein_coding | TCGA-64-1678-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | ||
DNAJC11 | SNV | Missense_Mutation | rs372201952 | c.962N>T | p.Arg321Leu | p.R321L | Q9NVH1 | protein_coding | deleterious(0) | benign(0.021) | TCGA-QK-A8Z8-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | PD |
DNAJC11 | insertion | Frame_Shift_Ins | novel | c.477_478insGCATCCTTTCATA | p.Asn160AlafsTer6 | p.N160Afs*6 | Q9NVH1 | protein_coding | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD | ||
DNAJC11 | SNV | Missense_Mutation | c.532N>A | p.Ala178Thr | p.A178T | Q9NVH1 | protein_coding | deleterious(0.04) | possibly_damaging(0.726) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DNAJC11 | SNV | Missense_Mutation | c.566N>T | p.Gly189Val | p.G189V | Q9NVH1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CD-8534-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
DNAJC11 | SNV | Missense_Mutation | rs755185368 | c.731A>G | p.Gln244Arg | p.Q244R | Q9NVH1 | protein_coding | deleterious(0.02) | possibly_damaging(0.726) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
DNAJC11 | SNV | Missense_Mutation | c.1396A>G | p.Asn466Asp | p.N466D | Q9NVH1 | protein_coding | tolerated(0.28) | benign(0.268) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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