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Gene: DLGAP1 |
Gene summary for DLGAP1 |
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Gene information | Species | Human | Gene symbol | DLGAP1 | Gene ID | 9229 |
Gene name | DLG associated protein 1 | |
Gene Alias | DAP-1 | |
Cytomap | 18p11.31 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | O14490 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9229 | DLGAP1 | AEH-subject5 | Human | Endometrium | AEH | 2.67e-02 | 2.88e-01 | -0.2953 |
9229 | DLGAP1 | EEC-subject1 | Human | Endometrium | EEC | 1.85e-06 | 3.16e-01 | -0.2682 |
9229 | DLGAP1 | EEC-subject3 | Human | Endometrium | EEC | 2.17e-04 | 3.12e-01 | -0.2525 |
9229 | DLGAP1 | EEC-subject5 | Human | Endometrium | EEC | 1.42e-03 | 2.64e-01 | -0.249 |
9229 | DLGAP1 | LZE7T | Human | Esophagus | ESCC | 1.02e-03 | 1.88e-01 | 0.0667 |
9229 | DLGAP1 | P2T-E | Human | Esophagus | ESCC | 2.13e-23 | 5.08e-01 | 0.1177 |
9229 | DLGAP1 | P5T-E | Human | Esophagus | ESCC | 8.06e-15 | 3.58e-01 | 0.1327 |
9229 | DLGAP1 | P10T-E | Human | Esophagus | ESCC | 1.74e-13 | 2.08e-01 | 0.116 |
9229 | DLGAP1 | P12T-E | Human | Esophagus | ESCC | 1.21e-03 | 1.53e-01 | 0.1122 |
9229 | DLGAP1 | P16T-E | Human | Esophagus | ESCC | 4.10e-10 | 2.44e-01 | 0.1153 |
9229 | DLGAP1 | P22T-E | Human | Esophagus | ESCC | 2.13e-04 | 6.94e-02 | 0.1236 |
9229 | DLGAP1 | P23T-E | Human | Esophagus | ESCC | 1.14e-03 | 1.42e-01 | 0.108 |
9229 | DLGAP1 | P26T-E | Human | Esophagus | ESCC | 2.96e-24 | 5.27e-01 | 0.1276 |
9229 | DLGAP1 | P27T-E | Human | Esophagus | ESCC | 8.54e-66 | 1.06e+00 | 0.1055 |
9229 | DLGAP1 | P32T-E | Human | Esophagus | ESCC | 1.25e-10 | 3.00e-01 | 0.1666 |
9229 | DLGAP1 | P37T-E | Human | Esophagus | ESCC | 3.53e-03 | 1.12e-01 | 0.1371 |
9229 | DLGAP1 | P39T-E | Human | Esophagus | ESCC | 6.38e-08 | 2.00e-01 | 0.0894 |
9229 | DLGAP1 | P42T-E | Human | Esophagus | ESCC | 9.05e-04 | 1.79e-01 | 0.1175 |
9229 | DLGAP1 | P54T-E | Human | Esophagus | ESCC | 6.60e-44 | 1.19e+00 | 0.0975 |
9229 | DLGAP1 | P57T-E | Human | Esophagus | ESCC | 8.15e-09 | 2.67e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DLGAP1 | SNV | Missense_Mutation | c.1547N>T | p.Pro516Leu | p.P516L | O14490 | protein_coding | tolerated(0.06) | benign(0.029) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DLGAP1 | SNV | Missense_Mutation | novel | c.71N>T | p.Ser24Leu | p.S24L | O14490 | protein_coding | tolerated(0.65) | benign(0.003) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
DLGAP1 | SNV | Missense_Mutation | novel | c.2138N>A | p.Ser713Tyr | p.S713Y | O14490 | protein_coding | tolerated(0.95) | possibly_damaging(0.797) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DLGAP1 | insertion | Frame_Shift_Ins | novel | c.1659_1660insCAGAGCC | p.Phe554GlnfsTer11 | p.F554Qfs*11 | O14490 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DLGAP1 | SNV | Missense_Mutation | novel | c.2650N>G | p.Ile884Val | p.I884V | O14490 | protein_coding | tolerated(0.9) | probably_damaging(0.994) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DLGAP1 | SNV | Missense_Mutation | c.2335N>T | p.Asp779Tyr | p.D779Y | O14490 | protein_coding | deleterious(0.01) | possibly_damaging(0.652) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DLGAP1 | SNV | Missense_Mutation | novel | c.2022C>A | p.Phe674Leu | p.F674L | O14490 | protein_coding | deleterious(0) | possibly_damaging(0.861) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DLGAP1 | SNV | Missense_Mutation | novel | c.1628C>A | p.Pro543His | p.P543H | O14490 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DLGAP1 | SNV | Missense_Mutation | novel | c.1328G>A | p.Arg443Gln | p.R443Q | O14490 | protein_coding | tolerated(0.17) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DLGAP1 | SNV | Missense_Mutation | rs766781410 | c.1028G>A | p.Arg343Gln | p.R343Q | O14490 | protein_coding | deleterious(0.01) | probably_damaging(0.975) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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