Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/DHRS9_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/DHRS9_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/DHRS9_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/DHRS9_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0034308 | Colorectum | AD | primary alcohol metabolic process | 35/3918 | 102/18723 | 1.16e-03 | 1.05e-02 | 35 |
GO:0008202 | Colorectum | AD | steroid metabolic process | 85/3918 | 319/18723 | 8.07e-03 | 4.75e-02 | 85 |
GO:00060661 | Colorectum | SER | alcohol metabolic process | 79/2897 | 353/18723 | 3.50e-04 | 5.50e-03 | 79 |
GO:00343081 | Colorectum | SER | primary alcohol metabolic process | 26/2897 | 102/18723 | 5.87e-03 | 4.29e-02 | 26 |
GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
GO:00463948 | Esophagus | ESCC | carboxylic acid biosynthetic process | 175/8552 | 314/18723 | 1.98e-04 | 1.26e-03 | 175 |
GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
GO:00421805 | Esophagus | ESCC | cellular ketone metabolic process | 120/8552 | 211/18723 | 6.70e-04 | 3.55e-03 | 120 |
GO:00082991 | Esophagus | ESCC | isoprenoid biosynthetic process | 21/8552 | 28/18723 | 1.57e-03 | 7.33e-03 | 21 |
GO:00060667 | Oral cavity | OSCC | alcohol metabolic process | 179/7305 | 353/18723 | 4.54e-06 | 5.21e-05 | 179 |
GO:00421804 | Oral cavity | OSCC | cellular ketone metabolic process | 111/7305 | 211/18723 | 3.94e-05 | 3.45e-04 | 111 |
GO:00160537 | Oral cavity | OSCC | organic acid biosynthetic process | 155/7305 | 316/18723 | 1.64e-04 | 1.13e-03 | 155 |
GO:00463947 | Oral cavity | OSCC | carboxylic acid biosynthetic process | 154/7305 | 314/18723 | 1.73e-04 | 1.19e-03 | 154 |
GO:0008299 | Oral cavity | OSCC | isoprenoid biosynthetic process | 20/7305 | 28/18723 | 5.13e-04 | 2.99e-03 | 20 |
GO:00067203 | Oral cavity | OSCC | isoprenoid metabolic process | 59/7305 | 116/18723 | 6.18e-03 | 2.33e-02 | 59 |
GO:00082024 | Oral cavity | OSCC | steroid metabolic process | 146/7305 | 319/18723 | 7.78e-03 | 2.85e-02 | 146 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DHRS9 | insertion | Frame_Shift_Ins | rs756920263 | c.849dupA | p.Leu284ThrfsTer21 | p.L284Tfs*21 | Q9BPW9 | protein_coding | | | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DHRS9 | deletion | Frame_Shift_Del | novel | c.177delN | p.Met61CysfsTer6 | p.M61Cfs*6 | Q9BPW9 | protein_coding | | | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
DHRS9 | insertion | Frame_Shift_Ins | rs756920263 | c.849dupA | p.Leu284ThrfsTer21 | p.L284Tfs*21 | Q9BPW9 | protein_coding | | | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DHRS9 | insertion | Frame_Shift_Ins | rs756920263 | c.841_842insA | p.Leu284ThrfsTer21 | p.L284Tfs*21 | Q9BPW9 | protein_coding | | | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DHRS9 | insertion | Nonsense_Mutation | novel | c.370_371insTTGAGATATTTTAATG | p.Ser124PhefsTer5 | p.S124Ffs*5 | Q9BPW9 | protein_coding | | | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DHRS9 | insertion | Frame_Shift_Ins | rs756920263 | c.841_842insA | p.Leu284ThrfsTer21 | p.L284Tfs*21 | Q9BPW9 | protein_coding | | | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DHRS9 | deletion | Frame_Shift_Del | novel | c.177delN | p.Met61CysfsTer6 | p.M61Cfs*6 | Q9BPW9 | protein_coding | | | TCGA-EY-A2OP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DHRS9 | SNV | Missense_Mutation | novel | c.713N>T | p.Pro238Leu | p.P238L | Q9BPW9 | protein_coding | tolerated(0.41) | benign(0.006) | TCGA-DD-AACK-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DHRS9 | SNV | Missense_Mutation | | c.206N>A | p.Leu69Gln | p.L69Q | Q9BPW9 | protein_coding | deleterious(0.02) | benign(0.269) | TCGA-G3-A25Z-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DHRS9 | insertion | Frame_Shift_Ins | rs756920263 | c.841_842insA | p.Leu284ThrfsTer21 | p.L284Tfs*21 | Q9BPW9 | protein_coding | | | TCGA-WQ-A9G7-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10170 | DHRS9 | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE | | (+)-ISOZONARONE | CHEMBL459574 | 19188072 |
10170 | DHRS9 | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE | | SESQUITERPENE O-BENZOQUINONE | CHEMBL517425 | 19188072 |
10170 | DHRS9 | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE | | PROTECTED SIPHONODICTYAL C | PROTECTED SIPHONODICTYAL C | 19188072 |
10170 | DHRS9 | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE | | (+/-)-SPONGIAQUINONE | CHEMBL514876 | 19188072 |
10170 | DHRS9 | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE | | (+/-)-HYATELLAQUINONE | CHEMBL456414 | 19188072 |
10170 | DHRS9 | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE | | (+/-)-WIEDENDIOL B | (+/-)-WIEDENDIOL B | 19188072 |
10170 | DHRS9 | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE | | (+)-ZONAROL | CHEMBL461471 | 19188072 |