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Gene: DDX56 |
Gene summary for DDX56 |
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Gene information | Species | Human | Gene symbol | DDX56 | Gene ID | 54606 |
Gene name | DEAD-box helicase 56 | |
Gene Alias | DDX21 | |
Cytomap | 7p13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NY93 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54606 | DDX56 | LZE2T | Human | Esophagus | ESCC | 7.45e-03 | 2.39e-01 | 0.082 |
54606 | DDX56 | LZE4T | Human | Esophagus | ESCC | 2.44e-08 | 3.09e-01 | 0.0811 |
54606 | DDX56 | LZE5T | Human | Esophagus | ESCC | 8.30e-05 | 3.42e-01 | 0.0514 |
54606 | DDX56 | LZE7T | Human | Esophagus | ESCC | 5.64e-11 | 5.62e-01 | 0.0667 |
54606 | DDX56 | LZE8T | Human | Esophagus | ESCC | 1.39e-09 | 2.63e-01 | 0.067 |
54606 | DDX56 | LZE22T | Human | Esophagus | ESCC | 2.12e-06 | 4.38e-01 | 0.068 |
54606 | DDX56 | LZE24T | Human | Esophagus | ESCC | 1.86e-20 | 5.36e-01 | 0.0596 |
54606 | DDX56 | LZE6T | Human | Esophagus | ESCC | 2.54e-09 | 3.80e-01 | 0.0845 |
54606 | DDX56 | P1T-E | Human | Esophagus | ESCC | 3.84e-14 | 4.90e-01 | 0.0875 |
54606 | DDX56 | P2T-E | Human | Esophagus | ESCC | 2.37e-29 | 5.18e-01 | 0.1177 |
54606 | DDX56 | P4T-E | Human | Esophagus | ESCC | 4.20e-25 | 6.45e-01 | 0.1323 |
54606 | DDX56 | P5T-E | Human | Esophagus | ESCC | 4.54e-13 | 1.73e-01 | 0.1327 |
54606 | DDX56 | P8T-E | Human | Esophagus | ESCC | 1.90e-25 | 3.86e-01 | 0.0889 |
54606 | DDX56 | P9T-E | Human | Esophagus | ESCC | 1.12e-17 | 4.24e-01 | 0.1131 |
54606 | DDX56 | P10T-E | Human | Esophagus | ESCC | 3.26e-31 | 5.51e-01 | 0.116 |
54606 | DDX56 | P11T-E | Human | Esophagus | ESCC | 2.78e-22 | 7.97e-01 | 0.1426 |
54606 | DDX56 | P12T-E | Human | Esophagus | ESCC | 2.63e-27 | 6.44e-01 | 0.1122 |
54606 | DDX56 | P15T-E | Human | Esophagus | ESCC | 4.09e-33 | 6.74e-01 | 0.1149 |
54606 | DDX56 | P16T-E | Human | Esophagus | ESCC | 9.83e-42 | 7.62e-01 | 0.1153 |
54606 | DDX56 | P17T-E | Human | Esophagus | ESCC | 1.36e-13 | 6.57e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:003134616 | Esophagus | ESCC | positive regulation of cell projection organization | 201/8552 | 353/18723 | 1.19e-05 | 1.11e-04 | 201 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:00109764 | Esophagus | ESCC | positive regulation of neuron projection development | 91/8552 | 163/18723 | 5.72e-03 | 2.13e-02 | 91 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:000636412 | Liver | Cirrhotic | rRNA processing | 115/4634 | 225/18723 | 1.12e-17 | 1.64e-15 | 115 |
GO:00160724 | Liver | Cirrhotic | rRNA metabolic process | 119/4634 | 236/18723 | 1.19e-17 | 1.70e-15 | 119 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX56 | SNV | Missense_Mutation | novel | c.961G>C | p.Gly321Arg | p.G321R | Q9NY93 | protein_coding | tolerated(0.32) | benign(0.021) | TCGA-34-2604-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX56 | SNV | Missense_Mutation | c.499G>A | p.Glu167Lys | p.E167K | Q9NY93 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-66-2758-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
DDX56 | deletion | Frame_Shift_Del | c.943delN | p.Thr315LeufsTer35 | p.T315Lfs*35 | Q9NY93 | protein_coding | TCGA-49-6761-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
DDX56 | SNV | Missense_Mutation | novel | c.1286G>T | p.Arg429Leu | p.R429L | Q9NY93 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-BA-4078-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DDX56 | SNV | Missense_Mutation | rs770985431 | c.992N>A | p.Arg331Gln | p.R331Q | Q9NY93 | protein_coding | tolerated(0.15) | benign(0) | TCGA-BA-6871-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DDX56 | SNV | Missense_Mutation | rs140918826 | c.566N>A | p.Arg189Gln | p.R189Q | Q9NY93 | protein_coding | deleterious(0.05) | benign(0.388) | TCGA-CH-5769-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
DDX56 | SNV | Missense_Mutation | c.431N>A | p.Arg144His | p.R144H | Q9NY93 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
DDX56 | SNV | Missense_Mutation | c.254N>A | p.Gly85Asp | p.G85D | Q9NY93 | protein_coding | deleterious(0) | possibly_damaging(0.529) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
DDX56 | SNV | Missense_Mutation | c.887N>A | p.Ser296Tyr | p.S296Y | Q9NY93 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BR-8365-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DDX56 | SNV | Missense_Mutation | c.469C>T | p.Arg157Cys | p.R157C | Q9NY93 | protein_coding | deleterious(0.01) | possibly_damaging(0.67) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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