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Gene: DDX39B |
Gene summary for DDX39B |
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Gene information | Species | Human | Gene symbol | DDX39B | Gene ID | 7919 |
Gene name | DExD-box helicase 39B | |
Gene Alias | BAT1 | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | A0A024RCM3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7919 | DDX39B | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.05e-23 | 4.15e-01 | 0.0155 |
7919 | DDX39B | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.82e-20 | 5.88e-01 | -0.1808 |
7919 | DDX39B | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.84e-10 | 5.85e-01 | 0.0216 |
7919 | DDX39B | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.76e-31 | 7.71e-01 | -0.0811 |
7919 | DDX39B | HTA11_78_2000001011 | Human | Colorectum | AD | 3.57e-32 | 6.94e-01 | -0.1088 |
7919 | DDX39B | HTA11_347_2000001011 | Human | Colorectum | AD | 3.89e-58 | 9.40e-01 | -0.1954 |
7919 | DDX39B | HTA11_411_2000001011 | Human | Colorectum | SER | 6.89e-14 | 9.53e-01 | -0.2602 |
7919 | DDX39B | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.90e-09 | 5.59e-01 | -0.2196 |
7919 | DDX39B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.96e-16 | 5.89e-01 | -0.1207 |
7919 | DDX39B | HTA11_83_2000001011 | Human | Colorectum | SER | 2.91e-27 | 7.43e-01 | -0.1526 |
7919 | DDX39B | HTA11_696_2000001011 | Human | Colorectum | AD | 1.66e-48 | 7.71e-01 | -0.1464 |
7919 | DDX39B | HTA11_866_2000001011 | Human | Colorectum | AD | 1.68e-40 | 7.09e-01 | -0.1001 |
7919 | DDX39B | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.17e-42 | 1.01e+00 | -0.059 |
7919 | DDX39B | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.50e-12 | 5.66e-01 | -0.1706 |
7919 | DDX39B | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.91e-11 | 4.78e-01 | -0.2061 |
7919 | DDX39B | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.17e-09 | 4.66e-01 | -0.1462 |
7919 | DDX39B | HTA11_546_2000001011 | Human | Colorectum | AD | 2.07e-24 | 8.00e-01 | -0.0842 |
7919 | DDX39B | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.27e-11 | 4.04e-01 | -0.0179 |
7919 | DDX39B | HTA11_866_3004761011 | Human | Colorectum | AD | 1.47e-27 | 6.15e-01 | 0.096 |
7919 | DDX39B | HTA11_4255_2000001011 | Human | Colorectum | SER | 6.82e-15 | 6.95e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:0022618 | Colorectum | AD | ribonucleoprotein complex assembly | 92/3918 | 220/18723 | 1.49e-12 | 2.60e-10 | 92 |
GO:0071826 | Colorectum | AD | ribonucleoprotein complex subunit organization | 94/3918 | 227/18723 | 1.70e-12 | 2.87e-10 | 94 |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0006913 | Colorectum | AD | nucleocytoplasmic transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0051169 | Colorectum | AD | nuclear transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0044403 | Colorectum | AD | biological process involved in symbiotic interaction | 99/3918 | 290/18723 | 1.02e-07 | 4.93e-06 | 99 |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0051054 | Colorectum | AD | positive regulation of DNA metabolic process | 73/3918 | 201/18723 | 3.27e-07 | 1.29e-05 | 73 |
GO:0051701 | Colorectum | AD | biological process involved in interaction with host | 73/3918 | 203/18723 | 5.08e-07 | 1.88e-05 | 73 |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
GO:0061008 | Colorectum | AD | hepaticobiliary system development | 55/3918 | 150/18723 | 6.34e-06 | 1.59e-04 | 55 |
GO:0001889 | Colorectum | AD | liver development | 54/3918 | 147/18723 | 7.20e-06 | 1.77e-04 | 54 |
GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03015 | Colorectum | AD | mRNA surveillance pathway | 35/2092 | 97/8465 | 7.95e-03 | 3.13e-02 | 2.00e-02 | 35 |
hsa030151 | Colorectum | AD | mRNA surveillance pathway | 35/2092 | 97/8465 | 7.95e-03 | 3.13e-02 | 2.00e-02 | 35 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030404 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030405 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa030159 | Esophagus | HGIN | mRNA surveillance pathway | 30/1383 | 97/8465 | 2.48e-04 | 2.69e-03 | 2.14e-03 | 30 |
hsa030137 | Esophagus | HGIN | Nucleocytoplasmic transport | 31/1383 | 108/8465 | 8.29e-04 | 7.95e-03 | 6.31e-03 | 31 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0301514 | Esophagus | HGIN | mRNA surveillance pathway | 30/1383 | 97/8465 | 2.48e-04 | 2.69e-03 | 2.14e-03 | 30 |
hsa0301312 | Esophagus | HGIN | Nucleocytoplasmic transport | 31/1383 | 108/8465 | 8.29e-04 | 7.95e-03 | 6.31e-03 | 31 |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0301524 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0301534 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304010 | Prostate | BPH | Spliceosome | 62/1718 | 217/8465 | 1.99e-03 | 7.92e-03 | 4.90e-03 | 62 |
hsa030155 | Prostate | BPH | mRNA surveillance pathway | 32/1718 | 97/8465 | 2.20e-03 | 8.63e-03 | 5.34e-03 | 32 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX39B | SNV | Missense_Mutation | novel | c.1197C>G | p.Ile399Met | p.I399M | Q13838 | protein_coding | tolerated(0.13) | benign(0.202) | TCGA-33-AASL-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DDX39B | SNV | Missense_Mutation | novel | c.887N>G | p.Ser296Cys | p.S296C | Q13838 | protein_coding | deleterious(0.02) | possibly_damaging(0.587) | TCGA-J9-A8CM-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
DDX39B | SNV | Missense_Mutation | novel | c.86N>G | p.Ala29Gly | p.A29G | Q13838 | protein_coding | tolerated(0.26) | benign(0) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
DDX39B | SNV | Missense_Mutation | rs757158055 | c.497C>T | p.Pro166Leu | p.P166L | Q13838 | protein_coding | deleterious(0.01) | possibly_damaging(0.904) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DDX39B | SNV | Missense_Mutation | novel | c.165G>T | p.Glu55Asp | p.E55D | Q13838 | protein_coding | deleterious(0.03) | probably_damaging(0.985) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
DDX39B | deletion | Frame_Shift_Del | c.447delT | p.Phe149LeufsTer13 | p.F149Lfs*13 | Q13838 | protein_coding | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
DDX39B | deletion | Frame_Shift_Del | c.447delN | p.Phe149LeufsTer13 | p.F149Lfs*13 | Q13838 | protein_coding | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
DDX39B | deletion | Frame_Shift_Del | c.447delN | p.Phe149LeufsTer13 | p.F149Lfs*13 | Q13838 | protein_coding | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
DDX39B | deletion | Frame_Shift_Del | c.447delN | p.Phe149LeufsTer13 | p.F149Lfs*13 | Q13838 | protein_coding | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |||
DDX39B | deletion | Frame_Shift_Del | c.447delT | p.Phe149LeufsTer13 | p.F149Lfs*13 | Q13838 | protein_coding | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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