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Gene: DDR2 |
Gene summary for DDR2 |
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Gene information | Species | Human | Gene symbol | DDR2 | Gene ID | 4921 |
Gene name | discoidin domain receptor tyrosine kinase 2 | |
Gene Alias | MIG20a | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | A0A024R906 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4921 | DDR2 | P2T-E | Human | Esophagus | ESCC | 1.05e-32 | 6.61e-01 | 0.1177 |
4921 | DDR2 | P4T-E | Human | Esophagus | ESCC | 2.11e-02 | 2.05e-01 | 0.1323 |
4921 | DDR2 | P9T-E | Human | Esophagus | ESCC | 3.61e-02 | 2.71e-01 | 0.1131 |
4921 | DDR2 | P11T-E | Human | Esophagus | ESCC | 2.77e-04 | 2.17e-01 | 0.1426 |
4921 | DDR2 | P16T-E | Human | Esophagus | ESCC | 1.00e-21 | 5.63e-01 | 0.1153 |
4921 | DDR2 | P44T-E | Human | Esophagus | ESCC | 7.37e-04 | 3.46e-01 | 0.1096 |
4921 | DDR2 | P56T-E | Human | Esophagus | ESCC | 5.16e-07 | 1.10e+00 | 0.1613 |
4921 | DDR2 | P76T-E | Human | Esophagus | ESCC | 1.98e-06 | 2.43e-01 | 0.1207 |
4921 | DDR2 | P130T-E | Human | Esophagus | ESCC | 9.11e-18 | 4.88e-01 | 0.1676 |
4921 | DDR2 | ATC11 | Human | Thyroid | ATC | 8.60e-08 | 1.16e+00 | 0.3386 |
4921 | DDR2 | ATC12 | Human | Thyroid | ATC | 5.88e-57 | 1.05e+00 | 0.34 |
4921 | DDR2 | ATC13 | Human | Thyroid | ATC | 6.70e-71 | 1.44e+00 | 0.34 |
4921 | DDR2 | ATC2 | Human | Thyroid | ATC | 1.14e-12 | 1.51e+00 | 0.34 |
4921 | DDR2 | ATC3 | Human | Thyroid | ATC | 2.54e-19 | 1.27e+00 | 0.338 |
4921 | DDR2 | ATC4 | Human | Thyroid | ATC | 5.19e-59 | 1.28e+00 | 0.34 |
4921 | DDR2 | ATC5 | Human | Thyroid | ATC | 2.22e-85 | 1.54e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
GO:000164918 | Esophagus | ESCC | osteoblast differentiation | 140/8552 | 229/18723 | 1.63e-06 | 1.95e-05 | 140 |
GO:004677710 | Esophagus | ESCC | protein autophosphorylation | 138/8552 | 227/18723 | 2.98e-06 | 3.38e-05 | 138 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:00510918 | Esophagus | ESCC | positive regulation of DNA-binding transcription factor activity | 155/8552 | 260/18723 | 3.83e-06 | 4.14e-05 | 155 |
GO:004814414 | Esophagus | ESCC | fibroblast proliferation | 57/8552 | 81/18723 | 5.83e-06 | 6.03e-05 | 57 |
GO:004586018 | Esophagus | ESCC | positive regulation of protein kinase activity | 219/8552 | 386/18723 | 6.91e-06 | 6.97e-05 | 219 |
GO:003367420 | Esophagus | ESCC | positive regulation of kinase activity | 260/8552 | 467/18723 | 7.26e-06 | 7.22e-05 | 260 |
GO:004814514 | Esophagus | ESCC | regulation of fibroblast proliferation | 56/8552 | 80/18723 | 9.08e-06 | 8.71e-05 | 56 |
GO:00301984 | Esophagus | ESCC | extracellular matrix organization | 171/8552 | 301/18723 | 6.08e-05 | 4.67e-04 | 171 |
GO:00430624 | Esophagus | ESCC | extracellular structure organization | 171/8552 | 302/18723 | 7.73e-05 | 5.76e-04 | 171 |
GO:00452294 | Esophagus | ESCC | external encapsulating structure organization | 172/8552 | 304/18723 | 7.80e-05 | 5.80e-04 | 172 |
GO:19030553 | Esophagus | ESCC | positive regulation of extracellular matrix organization | 20/8552 | 25/18723 | 4.81e-04 | 2.69e-03 | 20 |
GO:000166720 | Esophagus | ESCC | ameboidal-type cell migration | 250/8552 | 475/18723 | 1.22e-03 | 5.97e-03 | 250 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:00301993 | Esophagus | ESCC | collagen fibril organization | 40/8552 | 61/18723 | 1.35e-03 | 6.44e-03 | 40 |
GO:00107619 | Esophagus | ESCC | fibroblast migration | 32/8552 | 47/18723 | 1.59e-03 | 7.43e-03 | 32 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:00456675 | Esophagus | ESCC | regulation of osteoblast differentiation | 77/8552 | 132/18723 | 2.28e-03 | 1.00e-02 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDR2 | SNV | Missense_Mutation | c.1621C>T | p.Pro541Ser | p.P541S | Q16832 | protein_coding | deleterious(0.01) | probably_damaging(0.959) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DDR2 | SNV | Missense_Mutation | rs201041695 | c.2417G>A | p.Arg806Gln | p.R806Q | Q16832 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DDR2 | SNV | Missense_Mutation | rs773598662 | c.1433N>A | p.Arg478His | p.R478H | Q16832 | protein_coding | tolerated(0.12) | benign(0.04) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
DDR2 | SNV | Missense_Mutation | c.1625N>T | p.Ala542Val | p.A542V | Q16832 | protein_coding | deleterious(0.02) | benign(0.125) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
DDR2 | SNV | Missense_Mutation | rs779963287 | c.1892N>A | p.Arg631Gln | p.R631Q | Q16832 | protein_coding | tolerated(0.1) | probably_damaging(0.937) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
DDR2 | SNV | Missense_Mutation | rs759709680 | c.313N>T | p.Arg105Cys | p.R105C | Q16832 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6963-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DDR2 | SNV | Missense_Mutation | rs756942296 | c.377G>A | p.Gly126Asp | p.G126D | Q16832 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DDR2 | SNV | Missense_Mutation | rs371333028 | c.403C>T | p.Arg135Cys | p.R135C | Q16832 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D5-6531-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DDR2 | SNV | Missense_Mutation | rs771898787 | c.2560N>A | p.Asp854Asn | p.D854N | Q16832 | protein_coding | tolerated_low_confidence(0.08) | benign(0) | TCGA-D5-6926-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
DDR2 | SNV | Missense_Mutation | c.1981G>T | p.Asp661Tyr | p.D661Y | Q16832 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4921 | DDR2 | KINASE, TRANSCRIPTION FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, TYROSINE KINASE | ERLOTINIB | ERLOTINIB | 22328973 | |
4921 | DDR2 | KINASE, TRANSCRIPTION FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, TYROSINE KINASE | US9156852, 105 | |||
4921 | DDR2 | KINASE, TRANSCRIPTION FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, TYROSINE KINASE | inhibitor | 178102337 | SORAFENIB | |
4921 | DDR2 | KINASE, TRANSCRIPTION FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, TYROSINE KINASE | inhibitor | 384403668 | ||
4921 | DDR2 | KINASE, TRANSCRIPTION FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, TYROSINE KINASE | SARACATINIB | SARACATINIB | 26191369 | |
4921 | DDR2 | KINASE, TRANSCRIPTION FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, TYROSINE KINASE | inhibitor | 381118815 | ||
4921 | DDR2 | KINASE, TRANSCRIPTION FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, TYROSINE KINASE | inhibitor | 178102324 | NILOTINIB | |
4921 | DDR2 | KINASE, TRANSCRIPTION FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, TYROSINE KINASE | US9156852, 38 | |||
4921 | DDR2 | KINASE, TRANSCRIPTION FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, TYROSINE KINASE | US9156852, 1 | |||
4921 | DDR2 | KINASE, TRANSCRIPTION FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, TYROSINE KINASE | DASATINIB | DASATINIB | 22328973,23932362,18938156 |
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