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Gene: DCUN1D4 |
Gene summary for DCUN1D4 |
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Gene information | Species | Human | Gene symbol | DCUN1D4 | Gene ID | 23142 |
Gene name | defective in cullin neddylation 1 domain containing 4 | |
Gene Alias | DCNL4 | |
Cytomap | 4q12 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q92564 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23142 | DCUN1D4 | LZE2T | Human | Esophagus | ESCC | 1.31e-02 | 2.65e-01 | 0.082 |
23142 | DCUN1D4 | LZE7T | Human | Esophagus | ESCC | 1.56e-02 | 1.16e-01 | 0.0667 |
23142 | DCUN1D4 | LZE8T | Human | Esophagus | ESCC | 2.65e-02 | 5.80e-02 | 0.067 |
23142 | DCUN1D4 | LZE24T | Human | Esophagus | ESCC | 1.31e-03 | 1.14e-01 | 0.0596 |
23142 | DCUN1D4 | LZE6T | Human | Esophagus | ESCC | 1.97e-04 | 1.38e-01 | 0.0845 |
23142 | DCUN1D4 | P2T-E | Human | Esophagus | ESCC | 2.17e-11 | 1.08e-01 | 0.1177 |
23142 | DCUN1D4 | P4T-E | Human | Esophagus | ESCC | 1.22e-10 | 2.30e-01 | 0.1323 |
23142 | DCUN1D4 | P5T-E | Human | Esophagus | ESCC | 2.26e-10 | 4.53e-02 | 0.1327 |
23142 | DCUN1D4 | P9T-E | Human | Esophagus | ESCC | 4.54e-05 | 1.04e-01 | 0.1131 |
23142 | DCUN1D4 | P10T-E | Human | Esophagus | ESCC | 7.19e-12 | 9.85e-02 | 0.116 |
23142 | DCUN1D4 | P11T-E | Human | Esophagus | ESCC | 8.65e-09 | 3.30e-01 | 0.1426 |
23142 | DCUN1D4 | P12T-E | Human | Esophagus | ESCC | 6.72e-16 | 1.48e-01 | 0.1122 |
23142 | DCUN1D4 | P15T-E | Human | Esophagus | ESCC | 1.25e-06 | 1.65e-01 | 0.1149 |
23142 | DCUN1D4 | P16T-E | Human | Esophagus | ESCC | 2.47e-13 | 1.19e-01 | 0.1153 |
23142 | DCUN1D4 | P20T-E | Human | Esophagus | ESCC | 3.89e-09 | 7.37e-02 | 0.1124 |
23142 | DCUN1D4 | P21T-E | Human | Esophagus | ESCC | 1.32e-15 | 1.33e-01 | 0.1617 |
23142 | DCUN1D4 | P22T-E | Human | Esophagus | ESCC | 1.65e-15 | 1.16e-01 | 0.1236 |
23142 | DCUN1D4 | P23T-E | Human | Esophagus | ESCC | 3.80e-06 | 1.45e-01 | 0.108 |
23142 | DCUN1D4 | P24T-E | Human | Esophagus | ESCC | 5.26e-10 | 7.46e-02 | 0.1287 |
23142 | DCUN1D4 | P26T-E | Human | Esophagus | ESCC | 2.05e-12 | 1.03e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903320111 | Esophagus | ESCC | regulation of protein modification by small protein conjugation or removal | 181/8552 | 242/18723 | 1.80e-20 | 2.60e-18 | 181 |
GO:0031396111 | Esophagus | ESCC | regulation of protein ubiquitination | 154/8552 | 210/18723 | 2.70e-16 | 2.04e-14 | 154 |
GO:190332216 | Esophagus | ESCC | positive regulation of protein modification by small protein conjugation or removal | 99/8552 | 138/18723 | 4.39e-10 | 1.16e-08 | 99 |
GO:003139816 | Esophagus | ESCC | positive regulation of protein ubiquitination | 82/8552 | 119/18723 | 2.41e-07 | 3.64e-06 | 82 |
GO:005143819 | Esophagus | ESCC | regulation of ubiquitin-protein transferase activity | 38/8552 | 53/18723 | 1.10e-04 | 7.69e-04 | 38 |
GO:004511614 | Esophagus | ESCC | protein neddylation | 15/8552 | 18/18723 | 1.20e-03 | 5.88e-03 | 15 |
GO:00514433 | Esophagus | ESCC | positive regulation of ubiquitin-protein transferase activity | 21/8552 | 31/18723 | 1.10e-02 | 3.70e-02 | 21 |
GO:19033207 | Liver | NAFLD | regulation of protein modification by small protein conjugation or removal | 44/1882 | 242/18723 | 7.53e-05 | 1.56e-03 | 44 |
GO:00313967 | Liver | NAFLD | regulation of protein ubiquitination | 38/1882 | 210/18723 | 2.49e-04 | 4.12e-03 | 38 |
GO:00514384 | Liver | NAFLD | regulation of ubiquitin-protein transferase activity | 14/1882 | 53/18723 | 5.66e-04 | 7.59e-03 | 14 |
GO:190332022 | Liver | HCC | regulation of protein modification by small protein conjugation or removal | 167/7958 | 242/18723 | 4.99e-17 | 4.72e-15 | 167 |
GO:003139622 | Liver | HCC | regulation of protein ubiquitination | 142/7958 | 210/18723 | 1.39e-13 | 7.81e-12 | 142 |
GO:19033221 | Liver | HCC | positive regulation of protein modification by small protein conjugation or removal | 94/7958 | 138/18723 | 9.87e-10 | 3.01e-08 | 94 |
GO:00313981 | Liver | HCC | positive regulation of protein ubiquitination | 79/7958 | 119/18723 | 1.18e-07 | 2.26e-06 | 79 |
GO:005143821 | Liver | HCC | regulation of ubiquitin-protein transferase activity | 36/7958 | 53/18723 | 1.62e-04 | 1.29e-03 | 36 |
GO:00451161 | Liver | HCC | protein neddylation | 15/7958 | 18/18723 | 4.74e-04 | 3.12e-03 | 15 |
GO:0051443 | Liver | HCC | positive regulation of ubiquitin-protein transferase activity | 21/7958 | 31/18723 | 4.01e-03 | 1.76e-02 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DCUN1D4 | SNV | Missense_Mutation | c.539N>T | p.Pro180Leu | p.P180L | Q92564 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-44-8117-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
DCUN1D4 | SNV | Missense_Mutation | novel | c.297C>G | p.Asp99Glu | p.D99E | Q92564 | protein_coding | tolerated_low_confidence(0.07) | benign(0.04) | TCGA-73-4668-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | pemetrexed | PD |
DCUN1D4 | SNV | Missense_Mutation | novel | c.508N>C | p.Glu170Gln | p.E170Q | Q92564 | protein_coding | tolerated(0.1) | probably_damaging(0.96) | TCGA-52-7810-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DCUN1D4 | SNV | Missense_Mutation | novel | c.776N>G | p.Asn259Ser | p.N259S | Q92564 | protein_coding | deleterious(0.01) | benign(0.18) | TCGA-63-A5MI-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | vinorelbine | SD |
DCUN1D4 | SNV | Missense_Mutation | rs775715186 | c.761N>A | p.Arg254His | p.R254H | Q92564 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-98-A53B-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DCUN1D4 | SNV | Missense_Mutation | rs758053478 | c.256N>A | p.Asp86Asn | p.D86N | Q92564 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.693) | TCGA-NK-A5CX-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DCUN1D4 | SNV | Missense_Mutation | c.716N>G | p.Leu239Arg | p.L239R | Q92564 | protein_coding | tolerated(0.45) | possibly_damaging(0.474) | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
DCUN1D4 | SNV | Missense_Mutation | c.824T>C | p.Leu275Pro | p.L275P | Q92564 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-RD-A8NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
DCUN1D4 | insertion | Frame_Shift_Ins | novel | c.638_638+1insAT | p.Cys214TyrfsTer15 | p.C214Yfs*15 | Q92564 | protein_coding | TCGA-RD-A8N9-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD | ||
DCUN1D4 | SNV | Missense_Mutation | novel | c.576G>T | p.Leu192Phe | p.L192F | Q92564 | protein_coding | tolerated(0.22) | probably_damaging(0.943) | TCGA-EM-A2CK-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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