Tissue | Expression Dynamics | Abbreviation |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00301118 | Endometrium | AEH | regulation of Wnt signaling pathway | 71/2100 | 328/18723 | 3.31e-08 | 1.87e-06 | 71 |
GO:00160558 | Endometrium | AEH | Wnt signaling pathway | 85/2100 | 444/18723 | 4.99e-07 | 1.97e-05 | 85 |
GO:01987388 | Endometrium | AEH | cell-cell signaling by wnt | 85/2100 | 446/18723 | 6.07e-07 | 2.29e-05 | 85 |
GO:00163588 | Endometrium | AEH | dendrite development | 46/2100 | 243/18723 | 2.56e-04 | 3.03e-03 | 46 |
GO:00017642 | Endometrium | AEH | neuron migration | 31/2100 | 156/18723 | 1.08e-03 | 9.46e-03 | 31 |
GO:01200329 | Endometrium | AEH | regulation of plasma membrane bounded cell projection assembly | 34/2100 | 186/18723 | 2.79e-03 | 2.01e-02 | 34 |
GO:00604918 | Endometrium | AEH | regulation of cell projection assembly | 34/2100 | 188/18723 | 3.33e-03 | 2.32e-02 | 34 |
GO:003011113 | Endometrium | EEC | regulation of Wnt signaling pathway | 74/2168 | 328/18723 | 1.03e-08 | 6.47e-07 | 74 |
GO:001605513 | Endometrium | EEC | Wnt signaling pathway | 90/2168 | 444/18723 | 6.65e-08 | 3.50e-06 | 90 |
GO:019873813 | Endometrium | EEC | cell-cell signaling by wnt | 90/2168 | 446/18723 | 8.25e-08 | 4.23e-06 | 90 |
GO:00017641 | Endometrium | EEC | neuron migration | 33/2168 | 156/18723 | 4.17e-04 | 4.38e-03 | 33 |
GO:001635813 | Endometrium | EEC | dendrite development | 44/2168 | 243/18723 | 1.72e-03 | 1.34e-02 | 44 |
GO:012003214 | Endometrium | EEC | regulation of plasma membrane bounded cell projection assembly | 35/2168 | 186/18723 | 2.52e-03 | 1.84e-02 | 35 |
GO:006049114 | Endometrium | EEC | regulation of cell projection assembly | 35/2168 | 188/18723 | 3.02e-03 | 2.10e-02 | 35 |
GO:001605511 | Liver | Cirrhotic | Wnt signaling pathway | 150/4634 | 444/18723 | 9.75e-06 | 1.42e-04 | 150 |
GO:019873811 | Liver | Cirrhotic | cell-cell signaling by wnt | 150/4634 | 446/18723 | 1.28e-05 | 1.80e-04 | 150 |
GO:003011111 | Liver | Cirrhotic | regulation of Wnt signaling pathway | 112/4634 | 328/18723 | 7.57e-05 | 8.40e-04 | 112 |
GO:1902115 | Liver | Cirrhotic | regulation of organelle assembly | 66/4634 | 186/18723 | 6.66e-04 | 5.04e-03 | 66 |
GO:01200326 | Liver | Cirrhotic | regulation of plasma membrane bounded cell projection assembly | 63/4634 | 186/18723 | 3.16e-03 | 1.78e-02 | 63 |
GO:00604915 | Liver | Cirrhotic | regulation of cell projection assembly | 63/4634 | 188/18723 | 4.17e-03 | 2.22e-02 | 63 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DCDC2 | SNV | Missense_Mutation | novel | c.894N>T | p.Lys298Asn | p.K298N | Q9UHG0 | protein_coding | tolerated(0.13) | benign(0.051) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
DCDC2 | SNV | Missense_Mutation | novel | c.844N>A | p.Asp282Asn | p.D282N | Q9UHG0 | protein_coding | tolerated(0.29) | benign(0.035) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DCDC2 | SNV | Missense_Mutation | novel | c.268G>A | p.Gly90Ser | p.G90S | Q9UHG0 | protein_coding | deleterious(0) | possibly_damaging(0.532) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DCDC2 | deletion | Frame_Shift_Del | | c.970delG | p.Ala324GlnfsTer23 | p.A324Qfs*23 | Q9UHG0 | protein_coding | | | TCGA-B5-A5OC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
DCDC2 | deletion | Frame_Shift_Del | | c.970delN | p.Ala324GlnfsTer23 | p.A324Qfs*23 | Q9UHG0 | protein_coding | | | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
DCDC2 | SNV | Missense_Mutation | | c.875A>T | p.Lys292Ile | p.K292I | Q9UHG0 | protein_coding | deleterious(0.01) | possibly_damaging(0.77) | TCGA-CC-A7IJ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DCDC2 | SNV | Missense_Mutation | | c.938A>C | p.Lys313Thr | p.K313T | Q9UHG0 | protein_coding | deleterious(0.03) | benign(0.439) | TCGA-RC-A7SK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
DCDC2 | SNV | Missense_Mutation | novel | c.601N>A | p.Leu201Met | p.L201M | Q9UHG0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-WX-AA46-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DCDC2 | SNV | Missense_Mutation | | c.662N>T | p.Ser221Ile | p.S221I | Q9UHG0 | protein_coding | tolerated(0.4) | benign(0.022) | TCGA-ZS-A9CG-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DCDC2 | SNV | Missense_Mutation | | c.250N>T | p.Gly84Cys | p.G84C | Q9UHG0 | protein_coding | tolerated(0.13) | probably_damaging(0.987) | TCGA-05-4432-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |