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Gene: CYTH2 |
Gene summary for CYTH2 |
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Gene information | Species | Human | Gene symbol | CYTH2 | Gene ID | 9266 |
Gene name | cytohesin 2 | |
Gene Alias | ARNO | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q99418 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9266 | CYTH2 | LZE4T | Human | Esophagus | ESCC | 1.16e-09 | 2.08e-01 | 0.0811 |
9266 | CYTH2 | LZE7T | Human | Esophagus | ESCC | 6.55e-03 | 3.94e-01 | 0.0667 |
9266 | CYTH2 | LZE8T | Human | Esophagus | ESCC | 2.98e-07 | 6.71e-02 | 0.067 |
9266 | CYTH2 | LZE20T | Human | Esophagus | ESCC | 1.69e-05 | 1.53e-01 | 0.0662 |
9266 | CYTH2 | LZE24T | Human | Esophagus | ESCC | 1.36e-27 | 7.66e-01 | 0.0596 |
9266 | CYTH2 | LZE6T | Human | Esophagus | ESCC | 5.04e-07 | 9.81e-02 | 0.0845 |
9266 | CYTH2 | P1T-E | Human | Esophagus | ESCC | 7.63e-10 | 7.23e-01 | 0.0875 |
9266 | CYTH2 | P2T-E | Human | Esophagus | ESCC | 1.31e-19 | 4.02e-01 | 0.1177 |
9266 | CYTH2 | P4T-E | Human | Esophagus | ESCC | 8.36e-27 | 5.79e-01 | 0.1323 |
9266 | CYTH2 | P5T-E | Human | Esophagus | ESCC | 3.76e-22 | 2.51e-01 | 0.1327 |
9266 | CYTH2 | P8T-E | Human | Esophagus | ESCC | 4.51e-54 | 9.67e-01 | 0.0889 |
9266 | CYTH2 | P9T-E | Human | Esophagus | ESCC | 4.97e-05 | 3.44e-01 | 0.1131 |
9266 | CYTH2 | P10T-E | Human | Esophagus | ESCC | 7.75e-46 | 8.07e-01 | 0.116 |
9266 | CYTH2 | P11T-E | Human | Esophagus | ESCC | 1.97e-14 | 6.38e-01 | 0.1426 |
9266 | CYTH2 | P12T-E | Human | Esophagus | ESCC | 2.86e-29 | 5.19e-01 | 0.1122 |
9266 | CYTH2 | P15T-E | Human | Esophagus | ESCC | 4.07e-26 | 5.69e-01 | 0.1149 |
9266 | CYTH2 | P16T-E | Human | Esophagus | ESCC | 1.31e-21 | 2.30e-01 | 0.1153 |
9266 | CYTH2 | P17T-E | Human | Esophagus | ESCC | 9.40e-10 | 5.17e-01 | 0.1278 |
9266 | CYTH2 | P19T-E | Human | Esophagus | ESCC | 2.19e-04 | 5.47e-01 | 0.1662 |
9266 | CYTH2 | P20T-E | Human | Esophagus | ESCC | 1.89e-10 | 1.82e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:00465789 | Esophagus | ESCC | regulation of Ras protein signal transduction | 106/8552 | 189/18723 | 2.49e-03 | 1.08e-02 | 106 |
GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
GO:000726511 | Liver | Cirrhotic | Ras protein signal transduction | 119/4634 | 337/18723 | 8.16e-06 | 1.22e-04 | 119 |
GO:000726521 | Liver | HCC | Ras protein signal transduction | 187/7958 | 337/18723 | 8.89e-07 | 1.35e-05 | 187 |
GO:004657811 | Liver | HCC | regulation of Ras protein signal transduction | 100/7958 | 189/18723 | 2.42e-03 | 1.18e-02 | 100 |
GO:00072659 | Oral cavity | OSCC | Ras protein signal transduction | 185/7305 | 337/18723 | 1.95e-09 | 4.60e-08 | 185 |
GO:00465788 | Oral cavity | OSCC | regulation of Ras protein signal transduction | 90/7305 | 189/18723 | 9.58e-03 | 3.40e-02 | 90 |
GO:000726515 | Oral cavity | LP | Ras protein signal transduction | 109/4623 | 337/18723 | 8.44e-04 | 7.36e-03 | 109 |
GO:000726523 | Skin | cSCC | Ras protein signal transduction | 132/4864 | 337/18723 | 6.17e-08 | 1.57e-06 | 132 |
GO:000726519 | Thyroid | PTC | Ras protein signal transduction | 162/5968 | 337/18723 | 3.16e-10 | 1.02e-08 | 162 |
GO:005105617 | Thyroid | PTC | regulation of small GTPase mediated signal transduction | 132/5968 | 302/18723 | 9.26e-06 | 1.04e-04 | 132 |
GO:004657817 | Thyroid | PTC | regulation of Ras protein signal transduction | 88/5968 | 189/18723 | 1.62e-05 | 1.70e-04 | 88 |
GO:000726524 | Thyroid | ATC | Ras protein signal transduction | 172/6293 | 337/18723 | 2.25e-11 | 7.96e-10 | 172 |
GO:005105618 | Thyroid | ATC | regulation of small GTPase mediated signal transduction | 141/6293 | 302/18723 | 1.43e-06 | 1.77e-05 | 141 |
GO:004657818 | Thyroid | ATC | regulation of Ras protein signal transduction | 94/6293 | 189/18723 | 3.12e-06 | 3.55e-05 | 94 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05132211 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa05131211 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05130211 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa05132310 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa05131310 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05130310 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa0513222 | Liver | Cirrhotic | Salmonella infection | 121/2530 | 249/8465 | 2.47e-10 | 5.13e-09 | 3.16e-09 | 121 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0513022 | Liver | Cirrhotic | Pathogenic Escherichia coli infection | 88/2530 | 197/8465 | 6.48e-06 | 6.24e-05 | 3.84e-05 | 88 |
hsa0513122 | Liver | Cirrhotic | Shigellosis | 105/2530 | 247/8465 | 1.31e-05 | 1.21e-04 | 7.48e-05 | 105 |
hsa0513232 | Liver | Cirrhotic | Salmonella infection | 121/2530 | 249/8465 | 2.47e-10 | 5.13e-09 | 3.16e-09 | 121 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0513032 | Liver | Cirrhotic | Pathogenic Escherichia coli infection | 88/2530 | 197/8465 | 6.48e-06 | 6.24e-05 | 3.84e-05 | 88 |
hsa0513132 | Liver | Cirrhotic | Shigellosis | 105/2530 | 247/8465 | 1.31e-05 | 1.21e-04 | 7.48e-05 | 105 |
hsa0513242 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0513042 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
hsa0513142 | Liver | HCC | Shigellosis | 150/4020 | 247/8465 | 1.53e-05 | 1.04e-04 | 5.81e-05 | 150 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYTH2 | SNV | Missense_Mutation | novel | c.974A>G | p.Tyr325Cys | p.Y325C | Q99418 | protein_coding | deleterious(0.02) | probably_damaging(0.969) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
CYTH2 | SNV | Missense_Mutation | c.331N>C | p.Ile111Leu | p.I111L | Q99418 | protein_coding | deleterious(0) | possibly_damaging(0.809) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CYTH2 | SNV | Missense_Mutation | rs201629158 | c.292N>A | p.Arg98Ser | p.R98S | Q99418 | protein_coding | tolerated(0.11) | benign(0) | TCGA-18-3411-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CYTH2 | SNV | Missense_Mutation | novel | c.1065N>G | p.Ile355Met | p.I355M | Q99418 | protein_coding | tolerated(0.33) | benign(0.118) | TCGA-56-8309-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CYTH2 | SNV | Missense_Mutation | c.421G>T | p.Val141Leu | p.V141L | Q99418 | protein_coding | deleterious(0.02) | benign(0.031) | TCGA-60-2724-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD | |
CYTH2 | SNV | Missense_Mutation | novel | c.1053G>T | p.Met351Ile | p.M351I | Q99418 | protein_coding | tolerated(0.15) | benign(0) | TCGA-CR-5248-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD |
CYTH2 | SNV | Missense_Mutation | novel | c.485N>T | p.Arg162Leu | p.R162L | Q99418 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CR-7391-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CYTH2 | SNV | Missense_Mutation | novel | c.904N>G | p.Ile302Val | p.I302V | Q99418 | protein_coding | deleterious(0.04) | benign(0.082) | TCGA-MT-A67D-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CYTH2 | SNV | Missense_Mutation | rs760826182 | c.455G>A | p.Arg152His | p.R152H | Q99418 | protein_coding | deleterious(0.03) | probably_damaging(0.956) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
CYTH2 | SNV | Missense_Mutation | rs868252335 | c.652C>T | p.Arg218Trp | p.R218W | Q99418 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9266 | CYTH2 | NA | CLOTRIMAZOLE | CLOTRIMAZOLE |
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