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Gene: CUL9 |
Gene summary for CUL9 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CUL9 | Gene ID | 23113 |
Gene name | cullin 9 | |
Gene Alias | H7AP1 | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8IWT3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23113 | CUL9 | male-WTA | Human | Thyroid | PTC | 4.25e-03 | 7.50e-02 | 0.1037 |
23113 | CUL9 | PTC04 | Human | Thyroid | PTC | 6.69e-05 | 9.05e-02 | 0.1927 |
23113 | CUL9 | PTC05 | Human | Thyroid | PTC | 5.59e-04 | 2.11e-01 | 0.2065 |
23113 | CUL9 | PTC06 | Human | Thyroid | PTC | 7.40e-06 | 1.99e-01 | 0.2057 |
23113 | CUL9 | PTC07 | Human | Thyroid | PTC | 3.79e-10 | 1.17e-01 | 0.2044 |
23113 | CUL9 | ATC13 | Human | Thyroid | ATC | 3.00e-34 | 5.34e-01 | 0.34 |
23113 | CUL9 | ATC2 | Human | Thyroid | ATC | 6.46e-06 | 4.80e-01 | 0.34 |
23113 | CUL9 | ATC5 | Human | Thyroid | ATC | 2.52e-37 | 5.72e-01 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ATC: Anaplastic thyroid cancer | |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000734619 | Thyroid | PTC | regulation of mitotic cell cycle | 212/5968 | 457/18723 | 4.03e-11 | 1.44e-09 | 212 |
GO:01400148 | Thyroid | PTC | mitotic nuclear division | 135/5968 | 287/18723 | 4.90e-08 | 1.04e-06 | 135 |
GO:00482855 | Thyroid | PTC | organelle fission | 188/5968 | 488/18723 | 9.64e-04 | 5.77e-03 | 188 |
GO:00070885 | Thyroid | PTC | regulation of mitotic nuclear division | 51/5968 | 110/18723 | 1.02e-03 | 6.07e-03 | 51 |
GO:00002804 | Thyroid | PTC | nuclear division | 167/5968 | 439/18723 | 3.27e-03 | 1.60e-02 | 167 |
GO:00517833 | Thyroid | PTC | regulation of nuclear division | 59/5968 | 139/18723 | 5.50e-03 | 2.50e-02 | 59 |
GO:014001416 | Thyroid | ATC | mitotic nuclear division | 171/6293 | 287/18723 | 1.13e-19 | 1.66e-17 | 171 |
GO:000734622 | Thyroid | ATC | regulation of mitotic cell cycle | 236/6293 | 457/18723 | 7.58e-16 | 5.92e-14 | 236 |
GO:004828512 | Thyroid | ATC | organelle fission | 229/6293 | 488/18723 | 4.79e-10 | 1.29e-08 | 229 |
GO:000028011 | Thyroid | ATC | nuclear division | 207/6293 | 439/18723 | 1.98e-09 | 4.80e-08 | 207 |
GO:000708811 | Thyroid | ATC | regulation of mitotic nuclear division | 67/6293 | 110/18723 | 3.98e-09 | 9.08e-08 | 67 |
GO:005178311 | Thyroid | ATC | regulation of nuclear division | 77/6293 | 139/18723 | 1.01e-07 | 1.70e-06 | 77 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CUL9 | SNV | Missense_Mutation | rs769189873 | c.5320N>A | p.Val1774Met | p.V1774M | Q8IWT3 | protein_coding | deleterious(0.05) | possibly_damaging(0.657) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CUL9 | SNV | Missense_Mutation | c.5648N>G | p.His1883Arg | p.H1883R | Q8IWT3 | protein_coding | tolerated_low_confidence(0.15) | benign(0.021) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CUL9 | SNV | Missense_Mutation | rs368734594 | c.2020N>T | p.Arg674Cys | p.R674C | Q8IWT3 | protein_coding | deleterious(0) | possibly_damaging(0.635) | TCGA-AA-3831-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CUL9 | SNV | Missense_Mutation | c.3041C>A | p.Ser1014Tyr | p.S1014Y | Q8IWT3 | protein_coding | deleterious(0) | benign(0.089) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CUL9 | SNV | Missense_Mutation | rs368858642 | c.4267N>T | p.Arg1423Cys | p.R1423C | Q8IWT3 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CUL9 | SNV | Missense_Mutation | rs571511276 | c.2143N>T | p.Arg715Trp | p.R715W | Q8IWT3 | protein_coding | tolerated(0.05) | benign(0.333) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
CUL9 | SNV | Missense_Mutation | c.2416T>C | p.Ser806Pro | p.S806P | Q8IWT3 | protein_coding | tolerated(0.22) | benign(0) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CUL9 | SNV | Missense_Mutation | novel | c.5662C>A | p.Leu1888Ile | p.L1888I | Q8IWT3 | protein_coding | tolerated(0.08) | benign(0.131) | TCGA-AA-A02W-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CUL9 | SNV | Missense_Mutation | c.550N>T | p.Arg184Trp | p.R184W | Q8IWT3 | protein_coding | tolerated(0.22) | probably_damaging(0.993) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
CUL9 | SNV | Missense_Mutation | rs188248694 | c.4171N>A | p.Val1391Met | p.V1391M | Q8IWT3 | protein_coding | tolerated(0.07) | probably_damaging(0.96) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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