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Gene: CTNND1 |
Gene summary for CTNND1 |
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Gene information | Species | Human | Gene symbol | CTNND1 | Gene ID | 1500 |
Gene name | catenin delta 1 | |
Gene Alias | BCDS2 | |
Cytomap | 11q12.1 | |
Gene Type | protein-coding | GO ID | GO:0007043 | UniProtAcc | O60716 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1500 | CTNND1 | CCI_2 | Human | Cervix | CC | 2.80e-05 | 7.07e-01 | 0.5249 |
1500 | CTNND1 | CCI_3 | Human | Cervix | CC | 2.60e-04 | 6.68e-01 | 0.516 |
1500 | CTNND1 | Tumor | Human | Cervix | CC | 5.45e-48 | 8.98e-01 | 0.1241 |
1500 | CTNND1 | sample3 | Human | Cervix | CC | 1.64e-66 | 1.02e+00 | 0.1387 |
1500 | CTNND1 | H2 | Human | Cervix | HSIL_HPV | 1.76e-04 | 3.23e-01 | 0.0632 |
1500 | CTNND1 | T1 | Human | Cervix | CC | 4.54e-09 | 4.64e-01 | 0.0918 |
1500 | CTNND1 | T3 | Human | Cervix | CC | 1.35e-71 | 1.01e+00 | 0.1389 |
1500 | CTNND1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.61e-07 | 5.76e-01 | -0.1808 |
1500 | CTNND1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.07e-15 | 9.20e-01 | -0.0811 |
1500 | CTNND1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.44e-10 | 7.06e-01 | -0.1088 |
1500 | CTNND1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.29e-34 | 9.89e-01 | -0.1954 |
1500 | CTNND1 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.83e-05 | 9.31e-01 | -0.2602 |
1500 | CTNND1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.59e-03 | 7.83e-01 | -0.2196 |
1500 | CTNND1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.25e-09 | 7.14e-01 | -0.1526 |
1500 | CTNND1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.06e-06 | 8.87e-01 | -0.1706 |
1500 | CTNND1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.18e-09 | 8.90e-01 | -0.2061 |
1500 | CTNND1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 6.93e-03 | 3.73e-01 | -0.0179 |
1500 | CTNND1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.42e-05 | 4.91e-01 | 0.096 |
1500 | CTNND1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.21e-06 | 7.38e-01 | 0.0131 |
1500 | CTNND1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.49e-04 | 7.09e-01 | -0.0177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:00452169 | Cervix | CC | cell-cell junction organization | 53/2311 | 200/18723 | 3.83e-08 | 2.53e-06 | 53 |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:00608287 | Cervix | CC | regulation of canonical Wnt signaling pathway | 58/2311 | 253/18723 | 1.83e-06 | 5.89e-05 | 58 |
GO:00070439 | Cervix | CC | cell-cell junction assembly | 39/2311 | 146/18723 | 1.86e-06 | 5.94e-05 | 39 |
GO:00600707 | Cervix | CC | canonical Wnt signaling pathway | 66/2311 | 303/18723 | 2.47e-06 | 7.35e-05 | 66 |
GO:003164710 | Cervix | CC | regulation of protein stability | 63/2311 | 298/18723 | 1.14e-05 | 2.45e-04 | 63 |
GO:005082110 | Cervix | CC | protein stabilization | 43/2311 | 191/18723 | 5.90e-05 | 8.54e-04 | 43 |
GO:00301784 | Cervix | CC | negative regulation of Wnt signaling pathway | 35/2311 | 170/18723 | 1.52e-03 | 1.17e-02 | 35 |
GO:00900901 | Cervix | CC | negative regulation of canonical Wnt signaling pathway | 29/2311 | 137/18723 | 2.40e-03 | 1.70e-02 | 29 |
GO:0044331 | Cervix | CC | cell-cell adhesion mediated by cadherin | 9/2311 | 28/18723 | 5.02e-03 | 2.98e-02 | 9 |
GO:003164715 | Cervix | HSIL_HPV | regulation of protein stability | 31/737 | 298/18723 | 8.69e-07 | 4.19e-05 | 31 |
GO:004521614 | Cervix | HSIL_HPV | cell-cell junction organization | 23/737 | 200/18723 | 4.21e-06 | 1.69e-04 | 23 |
GO:000704314 | Cervix | HSIL_HPV | cell-cell junction assembly | 19/737 | 146/18723 | 4.72e-06 | 1.84e-04 | 19 |
GO:005082115 | Cervix | HSIL_HPV | protein stabilization | 21/737 | 191/18723 | 2.17e-05 | 6.58e-04 | 21 |
GO:003432913 | Cervix | HSIL_HPV | cell junction assembly | 28/737 | 420/18723 | 4.82e-03 | 3.98e-02 | 28 |
GO:0045216 | Colorectum | AD | cell-cell junction organization | 80/3918 | 200/18723 | 5.57e-10 | 4.58e-08 | 80 |
GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0452020 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa0467020 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa04520110 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa04670110 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa0401513 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0467025 | Cervix | HSIL_HPV | Leukocyte transendothelial migration | 16/459 | 114/8465 | 4.04e-04 | 3.49e-03 | 2.82e-03 | 16 |
hsa0467035 | Cervix | HSIL_HPV | Leukocyte transendothelial migration | 16/459 | 114/8465 | 4.04e-04 | 3.49e-03 | 2.82e-03 | 16 |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa04015 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa04670 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa040151 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa046701 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa045202 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa046702 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa040152 | Colorectum | SER | Rap1 signaling pathway | 54/1580 | 210/8465 | 6.55e-03 | 3.68e-02 | 2.67e-02 | 54 |
hsa045203 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa046703 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa040153 | Colorectum | SER | Rap1 signaling pathway | 54/1580 | 210/8465 | 6.55e-03 | 3.68e-02 | 2.67e-02 | 54 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTNND1 | insertion | Frame_Shift_Ins | novel | c.2681_2682insA | p.Ser895IlefsTer8 | p.S895Ifs*8 | O60716 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
CTNND1 | insertion | Frame_Shift_Ins | novel | c.2396_2397insA | p.Gln800ThrfsTer4 | p.Q800Tfs*4 | O60716 | protein_coding | TCGA-AA-3655-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CTNND1 | SNV | Missense_Mutation | novel | c.1807G>T | p.Ala603Ser | p.A603S | O60716 | protein_coding | tolerated(0.56) | benign(0.001) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CTNND1 | SNV | Missense_Mutation | c.947N>A | p.Arg316Gln | p.R316Q | O60716 | protein_coding | tolerated(0.08) | benign(0.022) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CTNND1 | SNV | Missense_Mutation | rs777282942 | c.1646N>A | p.Arg549Gln | p.R549Q | O60716 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CTNND1 | SNV | Missense_Mutation | rs780642639 | c.1750N>T | p.Arg584Trp | p.R584W | O60716 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CTNND1 | SNV | Missense_Mutation | c.1241N>C | p.Val414Ala | p.V414A | O60716 | protein_coding | deleterious(0.01) | possibly_damaging(0.891) | TCGA-A5-A0G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CTNND1 | SNV | Missense_Mutation | c.2773N>A | p.Asp925Asn | p.D925N | O60716 | protein_coding | tolerated(0.05) | benign(0.037) | TCGA-A5-A0GA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD | |
CTNND1 | SNV | Missense_Mutation | rs776716629 | c.259N>A | p.Gly87Arg | p.G87R | O60716 | protein_coding | deleterious(0.01) | possibly_damaging(0.483) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CTNND1 | SNV | Missense_Mutation | novel | c.1420N>A | p.Gly474Arg | p.G474R | O60716 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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