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Gene: CRMP1 |
Gene summary for CRMP1 |
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Gene information | Species | Human | Gene symbol | CRMP1 | Gene ID | 1400 |
Gene name | collapsin response mediator protein 1 | |
Gene Alias | CRMP-1 | |
Cytomap | 4p16.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | B3KT07 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1400 | CRMP1 | LZE7T | Human | Esophagus | ESCC | 8.32e-04 | 2.55e-01 | 0.0667 |
1400 | CRMP1 | P10T-E | Human | Esophagus | ESCC | 1.56e-08 | 2.10e-01 | 0.116 |
1400 | CRMP1 | P12T-E | Human | Esophagus | ESCC | 2.63e-13 | 4.21e-01 | 0.1122 |
1400 | CRMP1 | P21T-E | Human | Esophagus | ESCC | 2.96e-04 | 1.42e-01 | 0.1617 |
1400 | CRMP1 | P26T-E | Human | Esophagus | ESCC | 2.18e-02 | 8.32e-02 | 0.1276 |
1400 | CRMP1 | P28T-E | Human | Esophagus | ESCC | 2.45e-18 | 3.63e-01 | 0.1149 |
1400 | CRMP1 | P30T-E | Human | Esophagus | ESCC | 1.11e-14 | 7.72e-01 | 0.137 |
1400 | CRMP1 | P32T-E | Human | Esophagus | ESCC | 6.66e-09 | 2.29e-01 | 0.1666 |
1400 | CRMP1 | P49T-E | Human | Esophagus | ESCC | 1.17e-10 | 8.88e-01 | 0.1768 |
1400 | CRMP1 | P52T-E | Human | Esophagus | ESCC | 1.54e-12 | 3.82e-01 | 0.1555 |
1400 | CRMP1 | P74T-E | Human | Esophagus | ESCC | 5.51e-09 | 3.29e-01 | 0.1479 |
1400 | CRMP1 | P107T-E | Human | Esophagus | ESCC | 9.41e-05 | 2.51e-01 | 0.171 |
1400 | CRMP1 | ATC13 | Human | Thyroid | ATC | 3.80e-36 | 7.75e-01 | 0.34 |
1400 | CRMP1 | ATC3 | Human | Thyroid | ATC | 6.22e-03 | 2.13e-01 | 0.338 |
1400 | CRMP1 | ATC5 | Human | Thyroid | ATC | 2.60e-44 | 8.31e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:004339320 | Esophagus | ESCC | regulation of protein binding | 135/8552 | 196/18723 | 3.69e-11 | 1.22e-09 | 135 |
GO:0051100111 | Esophagus | ESCC | negative regulation of binding | 109/8552 | 162/18723 | 2.10e-08 | 4.03e-07 | 109 |
GO:003209116 | Esophagus | ESCC | negative regulation of protein binding | 65/8552 | 94/18723 | 3.46e-06 | 3.82e-05 | 65 |
GO:006156415 | Esophagus | ESCC | axon development | 251/8552 | 467/18723 | 2.41e-04 | 1.49e-03 | 251 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:000740915 | Esophagus | ESCC | axonogenesis | 219/8552 | 418/18723 | 3.14e-03 | 1.31e-02 | 219 |
GO:005109834 | Thyroid | ATC | regulation of binding | 203/6293 | 363/18723 | 1.18e-18 | 1.55e-16 | 203 |
GO:004339327 | Thyroid | ATC | regulation of protein binding | 110/6293 | 196/18723 | 6.99e-11 | 2.22e-09 | 110 |
GO:001097523 | Thyroid | ATC | regulation of neuron projection development | 212/6293 | 445/18723 | 4.16e-10 | 1.14e-08 | 212 |
GO:006156423 | Thyroid | ATC | axon development | 220/6293 | 467/18723 | 6.85e-10 | 1.80e-08 | 220 |
GO:000740919 | Thyroid | ATC | axonogenesis | 197/6293 | 418/18723 | 5.09e-09 | 1.13e-07 | 197 |
GO:005110027 | Thyroid | ATC | negative regulation of binding | 86/6293 | 162/18723 | 2.41e-07 | 3.73e-06 | 86 |
GO:003209119 | Thyroid | ATC | negative regulation of protein binding | 51/6293 | 94/18723 | 2.97e-05 | 2.48e-04 | 51 |
GO:003134514 | Thyroid | ATC | negative regulation of cell projection organization | 86/6293 | 186/18723 | 2.25e-04 | 1.46e-03 | 86 |
GO:001097712 | Thyroid | ATC | negative regulation of neuron projection development | 66/6293 | 137/18723 | 2.82e-04 | 1.80e-03 | 66 |
GO:00074113 | Thyroid | ATC | axon guidance | 96/6293 | 227/18723 | 3.74e-03 | 1.63e-02 | 96 |
GO:00974853 | Thyroid | ATC | neuron projection guidance | 96/6293 | 228/18723 | 4.36e-03 | 1.81e-02 | 96 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRMP1 | SNV | Missense_Mutation | novel | c.949N>T | p.Asp317Tyr | p.D317Y | Q14194 | protein_coding | deleterious(0) | probably_damaging(0.919) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CRMP1 | SNV | Missense_Mutation | rs762086490 | c.1753N>T | p.Arg585Trp | p.R585W | Q14194 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-EI-6884-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5 | SD |
CRMP1 | SNV | Missense_Mutation | rs768538875 | c.1699G>A | p.Val567Ile | p.V567I | Q14194 | protein_coding | deleterious(0.01) | benign(0.031) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CRMP1 | SNV | Missense_Mutation | novel | c.605A>T | p.Asp202Val | p.D202V | Q14194 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRMP1 | SNV | Missense_Mutation | rs374326359 | c.1336G>A | p.Gly446Ser | p.G446S | Q14194 | protein_coding | tolerated(0.43) | benign(0.053) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CRMP1 | SNV | Missense_Mutation | rs376766526 | c.715N>A | p.Glu239Lys | p.E239K | Q14194 | protein_coding | tolerated(0.13) | benign(0.058) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRMP1 | SNV | Missense_Mutation | c.483N>T | p.Glu161Asp | p.E161D | Q14194 | protein_coding | tolerated(0.25) | benign(0) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CRMP1 | SNV | Missense_Mutation | rs373508403 | c.530N>A | p.Arg177Gln | p.R177Q | Q14194 | protein_coding | tolerated(0.33) | benign(0.05) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CRMP1 | SNV | Missense_Mutation | c.820G>T | p.Gly274Cys | p.G274C | Q14194 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CRMP1 | SNV | Missense_Mutation | rs757384732 | c.1783N>T | p.Arg595Cys | p.R595C | Q14194 | protein_coding | deleterious(0.01) | possibly_damaging(0.8) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1400 | CRMP1 | NA | METHIMAZOLE | METHIMAZOLE | 11694350 |
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