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Gene: CRLF3 |
Gene summary for CRLF3 |
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Gene information | Species | Human | Gene symbol | CRLF3 | Gene ID | 51379 |
Gene name | cytokine receptor like factor 3 | |
Gene Alias | CREME-9 | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | Q8IUI8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51379 | CRLF3 | LZE4T | Human | Esophagus | ESCC | 7.67e-09 | 1.94e-01 | 0.0811 |
51379 | CRLF3 | LZE7T | Human | Esophagus | ESCC | 3.71e-04 | 3.03e-01 | 0.0667 |
51379 | CRLF3 | LZE24T | Human | Esophagus | ESCC | 4.88e-13 | 2.82e-01 | 0.0596 |
51379 | CRLF3 | LZE6T | Human | Esophagus | ESCC | 1.68e-05 | 3.07e-01 | 0.0845 |
51379 | CRLF3 | P1T-E | Human | Esophagus | ESCC | 9.78e-03 | 1.75e-01 | 0.0875 |
51379 | CRLF3 | P2T-E | Human | Esophagus | ESCC | 7.36e-19 | 2.26e-01 | 0.1177 |
51379 | CRLF3 | P4T-E | Human | Esophagus | ESCC | 2.90e-15 | 2.38e-01 | 0.1323 |
51379 | CRLF3 | P5T-E | Human | Esophagus | ESCC | 8.45e-13 | 2.02e-01 | 0.1327 |
51379 | CRLF3 | P8T-E | Human | Esophagus | ESCC | 3.73e-18 | 1.27e-01 | 0.0889 |
51379 | CRLF3 | P9T-E | Human | Esophagus | ESCC | 1.32e-11 | 1.67e-01 | 0.1131 |
51379 | CRLF3 | P10T-E | Human | Esophagus | ESCC | 4.94e-13 | 7.23e-02 | 0.116 |
51379 | CRLF3 | P11T-E | Human | Esophagus | ESCC | 4.38e-08 | 3.15e-01 | 0.1426 |
51379 | CRLF3 | P12T-E | Human | Esophagus | ESCC | 8.50e-17 | 2.41e-01 | 0.1122 |
51379 | CRLF3 | P15T-E | Human | Esophagus | ESCC | 3.10e-17 | 3.18e-01 | 0.1149 |
51379 | CRLF3 | P16T-E | Human | Esophagus | ESCC | 6.05e-09 | 1.94e-01 | 0.1153 |
51379 | CRLF3 | P17T-E | Human | Esophagus | ESCC | 2.38e-05 | 2.82e-01 | 0.1278 |
51379 | CRLF3 | P19T-E | Human | Esophagus | ESCC | 2.26e-02 | 2.97e-01 | 0.1662 |
51379 | CRLF3 | P20T-E | Human | Esophagus | ESCC | 1.26e-13 | 1.97e-01 | 0.1124 |
51379 | CRLF3 | P21T-E | Human | Esophagus | ESCC | 1.39e-16 | 3.59e-01 | 0.1617 |
51379 | CRLF3 | P22T-E | Human | Esophagus | ESCC | 2.73e-12 | 2.25e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:000008214 | Esophagus | ESCC | G1/S transition of mitotic cell cycle | 134/8552 | 214/18723 | 4.04e-07 | 5.55e-06 | 134 |
GO:004484314 | Esophagus | ESCC | cell cycle G1/S phase transition | 148/8552 | 241/18723 | 5.68e-07 | 7.48e-06 | 148 |
GO:00459267 | Esophagus | ESCC | negative regulation of growth | 148/8552 | 249/18723 | 7.88e-06 | 7.73e-05 | 148 |
GO:00303085 | Esophagus | ESCC | negative regulation of cell growth | 108/8552 | 188/18723 | 7.46e-04 | 3.87e-03 | 108 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRLF3 | SNV | Missense_Mutation | novel | c.556N>A | p.Glu186Lys | p.E186K | Q8IUI8 | protein_coding | deleterious(0.02) | probably_damaging(0.96) | TCGA-G3-AAV0-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CRLF3 | SNV | Missense_Mutation | c.957N>G | p.Phe319Leu | p.F319L | Q8IUI8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-22-5491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CRLF3 | SNV | Missense_Mutation | c.1309N>C | p.Trp437Arg | p.W437R | Q8IUI8 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-37-3783-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
CRLF3 | SNV | Missense_Mutation | novel | c.991G>C | p.Asp331His | p.D331H | Q8IUI8 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-56-8625-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
CRLF3 | SNV | Missense_Mutation | c.743G>C | p.Arg248Thr | p.R248T | Q8IUI8 | protein_coding | deleterious(0) | possibly_damaging(0.866) | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD | |
CRLF3 | SNV | Missense_Mutation | c.10N>T | p.Ala4Ser | p.A4S | Q8IUI8 | protein_coding | tolerated_low_confidence(0.44) | benign(0.006) | TCGA-NC-A5HJ-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | |
CRLF3 | SNV | Missense_Mutation | novel | c.1292N>T | p.Ser431Leu | p.S431L | Q8IUI8 | protein_coding | deleterious(0.04) | benign(0.068) | TCGA-BB-A5HY-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
CRLF3 | SNV | Missense_Mutation | c.839N>A | p.Gly280Asp | p.G280D | Q8IUI8 | protein_coding | tolerated(0.08) | probably_damaging(0.975) | TCGA-CQ-A4CB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
CRLF3 | SNV | Missense_Mutation | novel | c.244N>A | p.Asp82Asn | p.D82N | Q8IUI8 | protein_coding | deleterious(0.01) | benign(0.436) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
CRLF3 | SNV | Missense_Mutation | novel | c.991N>C | p.Asp331His | p.D331H | Q8IUI8 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-D7-A6EZ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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