GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051403 | Colorectum | AD | stress-activated MAPK cascade | 72/3918 | 239/18723 | 4.77e-04 | 5.25e-03 | 72 |
GO:0031098 | Colorectum | AD | stress-activated protein kinase signaling cascade | 74/3918 | 247/18723 | 4.80e-04 | 5.27e-03 | 74 |
GO:0070302 | Colorectum | AD | regulation of stress-activated protein kinase signaling cascade | 58/3918 | 195/18723 | 2.21e-03 | 1.74e-02 | 58 |
GO:0032872 | Colorectum | AD | regulation of stress-activated MAPK cascade | 57/3918 | 192/18723 | 2.51e-03 | 1.92e-02 | 57 |
GO:0032411 | Colorectum | AD | positive regulation of transporter activity | 37/3918 | 120/18723 | 6.82e-03 | 4.22e-02 | 37 |
GO:00324111 | Colorectum | SER | positive regulation of transporter activity | 31/2897 | 120/18723 | 2.25e-03 | 2.16e-02 | 31 |
GO:00310981 | Colorectum | SER | stress-activated protein kinase signaling cascade | 54/2897 | 247/18723 | 4.65e-03 | 3.67e-02 | 54 |
GO:0032409 | Colorectum | SER | regulation of transporter activity | 65/2897 | 310/18723 | 5.71e-03 | 4.19e-02 | 65 |
GO:00514031 | Colorectum | SER | stress-activated MAPK cascade | 52/2897 | 239/18723 | 5.96e-03 | 4.35e-02 | 52 |
GO:00310982 | Colorectum | MSS | stress-activated protein kinase signaling cascade | 67/3467 | 247/18723 | 5.28e-04 | 5.99e-03 | 67 |
GO:00514032 | Colorectum | MSS | stress-activated MAPK cascade | 65/3467 | 239/18723 | 5.87e-04 | 6.49e-03 | 65 |
GO:00324091 | Colorectum | MSS | regulation of transporter activity | 78/3467 | 310/18723 | 2.09e-03 | 1.78e-02 | 78 |
GO:0034764 | Colorectum | MSS | positive regulation of transmembrane transport | 58/3467 | 219/18723 | 2.19e-03 | 1.83e-02 | 58 |
GO:00324112 | Colorectum | MSS | positive regulation of transporter activity | 35/3467 | 120/18723 | 2.95e-03 | 2.28e-02 | 35 |
GO:00703021 | Colorectum | MSS | regulation of stress-activated protein kinase signaling cascade | 52/3467 | 195/18723 | 3.07e-03 | 2.34e-02 | 52 |
GO:0022898 | Colorectum | MSS | regulation of transmembrane transporter activity | 70/3467 | 278/18723 | 3.36e-03 | 2.54e-02 | 70 |
GO:00328721 | Colorectum | MSS | regulation of stress-activated MAPK cascade | 51/3467 | 192/18723 | 3.65e-03 | 2.69e-02 | 51 |
GO:0032412 | Colorectum | MSS | regulation of ion transmembrane transporter activity | 66/3467 | 267/18723 | 6.72e-03 | 4.38e-02 | 66 |
GO:00310983 | Colorectum | FAP | stress-activated protein kinase signaling cascade | 61/2622 | 247/18723 | 4.79e-06 | 1.57e-04 | 61 |
GO:00514033 | Colorectum | FAP | stress-activated MAPK cascade | 59/2622 | 239/18723 | 6.90e-06 | 2.11e-04 | 59 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRACR2A | SNV | Missense_Mutation | | c.1573N>A | p.Gln525Lys | p.Q525K | Q9BSW2 | protein_coding | tolerated(0.05) | possibly_damaging(0.546) | TCGA-B5-A11G-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRACR2A | SNV | Missense_Mutation | novel | c.605N>T | p.Thr202Ile | p.T202I | Q9BSW2 | protein_coding | tolerated(0.1) | benign(0.077) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRACR2A | SNV | Missense_Mutation | | c.707N>G | p.Leu236Arg | p.L236R | Q9BSW2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0U8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
CRACR2A | SNV | Missense_Mutation | rs761233575 | c.1138C>T | p.Arg380Trp | p.R380W | Q9BSW2 | protein_coding | deleterious(0) | possibly_damaging(0.809) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CRACR2A | SNV | Missense_Mutation | novel | c.1275N>T | p.Gln425His | p.Q425H | Q9BSW2 | protein_coding | tolerated(0.08) | possibly_damaging(0.606) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRACR2A | SNV | Missense_Mutation | novel | c.788N>A | p.Ser263Asn | p.S263N | Q9BSW2 | protein_coding | tolerated(0.09) | probably_damaging(0.973) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRACR2A | SNV | Missense_Mutation | novel | c.2039A>G | p.Asn680Ser | p.N680S | Q9BSW2 | protein_coding | tolerated(0.37) | benign(0.35) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
CRACR2A | SNV | Missense_Mutation | rs148261182 | c.481N>T | p.Arg161Trp | p.R161W | Q9BSW2 | protein_coding | tolerated(0.18) | benign(0.019) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CRACR2A | SNV | Missense_Mutation | | c.744N>T | p.Lys248Asn | p.K248N | Q9BSW2 | protein_coding | deleterious(0) | possibly_damaging(0.714) | TCGA-DI-A0WH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CRACR2A | SNV | Missense_Mutation | novel | c.2149N>G | p.Thr717Ala | p.T717A | Q9BSW2 | protein_coding | tolerated(0.24) | benign(0.003) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |