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Gene: CNTNAP2 |
Gene summary for CNTNAP2 |
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Gene information | Species | Human | Gene symbol | CNTNAP2 | Gene ID | 26047 |
Gene name | contactin associated protein 2 | |
Gene Alias | AUTS15 | |
Cytomap | 7q35-q36.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A090N7T7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26047 | CNTNAP2 | GSM4909290 | Human | Breast | IDC | 3.72e-37 | 6.88e-01 | 0.2096 |
26047 | CNTNAP2 | GSM4909293 | Human | Breast | IDC | 3.80e-09 | 1.65e-01 | 0.1581 |
26047 | CNTNAP2 | GSM4909294 | Human | Breast | IDC | 1.77e-06 | 1.72e-01 | 0.2022 |
26047 | CNTNAP2 | GSM4909298 | Human | Breast | IDC | 3.78e-06 | 1.48e-01 | 0.1551 |
26047 | CNTNAP2 | GSM4909304 | Human | Breast | IDC | 6.74e-13 | 2.24e-01 | 0.1636 |
26047 | CNTNAP2 | GSM4909306 | Human | Breast | IDC | 3.11e-02 | 8.10e-02 | 0.1564 |
26047 | CNTNAP2 | GSM4909321 | Human | Breast | IDC | 3.11e-02 | 1.54e-01 | 0.1559 |
26047 | CNTNAP2 | M1 | Human | Breast | IDC | 1.49e-02 | 1.19e-01 | 0.1577 |
26047 | CNTNAP2 | M5 | Human | Breast | IDC | 5.22e-12 | 5.75e-01 | 0.1598 |
26047 | CNTNAP2 | NCCBC11 | Human | Breast | DCIS | 3.06e-02 | 2.54e-01 | 0.1232 |
26047 | CNTNAP2 | P2 | Human | Breast | IDC | 3.13e-04 | 1.93e-01 | 0.21 |
26047 | CNTNAP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.91e-05 | 2.97e-01 | -0.1954 |
26047 | CNTNAP2 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.59e-02 | 5.43e-01 | -0.2602 |
26047 | CNTNAP2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.60e-02 | 3.00e-01 | -0.1207 |
26047 | CNTNAP2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.41e-07 | 4.16e-01 | -0.059 |
26047 | CNTNAP2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.96e-26 | 1.14e+00 | 0.281 |
26047 | CNTNAP2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.69e-04 | 2.55e-01 | 0.3859 |
26047 | CNTNAP2 | LZE4T | Human | Esophagus | ESCC | 1.55e-10 | 5.15e-01 | 0.0811 |
26047 | CNTNAP2 | P4T-E | Human | Esophagus | ESCC | 9.91e-08 | 2.03e-01 | 0.1323 |
26047 | CNTNAP2 | P5T-E | Human | Esophagus | ESCC | 3.41e-36 | 7.16e-01 | 0.1327 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000961211 | Breast | IDC | response to mechanical stimulus | 34/1434 | 216/18723 | 4.59e-05 | 1.03e-03 | 34 |
GO:000961221 | Breast | DCIS | response to mechanical stimulus | 32/1390 | 216/18723 | 1.36e-04 | 2.33e-03 | 32 |
GO:0045216 | Colorectum | AD | cell-cell junction organization | 80/3918 | 200/18723 | 5.57e-10 | 4.58e-08 | 80 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0007043 | Colorectum | AD | cell-cell junction assembly | 57/3918 | 146/18723 | 4.18e-07 | 1.61e-05 | 57 |
GO:1901888 | Colorectum | AD | regulation of cell junction assembly | 61/3918 | 204/18723 | 1.50e-03 | 1.27e-02 | 61 |
GO:00452161 | Colorectum | SER | cell-cell junction organization | 63/2897 | 200/18723 | 9.15e-09 | 7.80e-07 | 63 |
GO:00070431 | Colorectum | SER | cell-cell junction assembly | 45/2897 | 146/18723 | 2.23e-06 | 9.31e-05 | 45 |
GO:00343291 | Colorectum | SER | cell junction assembly | 100/2897 | 420/18723 | 4.23e-06 | 1.61e-04 | 100 |
GO:19018881 | Colorectum | SER | regulation of cell junction assembly | 46/2897 | 204/18723 | 4.70e-03 | 3.70e-02 | 46 |
GO:00452162 | Colorectum | MSS | cell-cell junction organization | 69/3467 | 200/18723 | 5.07e-08 | 2.70e-06 | 69 |
GO:00343292 | Colorectum | MSS | cell junction assembly | 120/3467 | 420/18723 | 2.51e-07 | 1.07e-05 | 120 |
GO:00070432 | Colorectum | MSS | cell-cell junction assembly | 50/3467 | 146/18723 | 4.24e-06 | 1.21e-04 | 50 |
GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
GO:000961216 | Esophagus | ESCC | response to mechanical stimulus | 124/8552 | 216/18723 | 3.30e-04 | 1.94e-03 | 124 |
GO:004521620 | Esophagus | ESCC | cell-cell junction organization | 114/8552 | 200/18723 | 8.04e-04 | 4.16e-03 | 114 |
GO:00215436 | Esophagus | ESCC | pallium development | 94/8552 | 169/18723 | 5.79e-03 | 2.14e-02 | 94 |
GO:190188810 | Esophagus | ESCC | regulation of cell junction assembly | 109/8552 | 204/18723 | 1.53e-02 | 4.96e-02 | 109 |
GO:004521622 | Liver | HCC | cell-cell junction organization | 107/7958 | 200/18723 | 1.06e-03 | 6.11e-03 | 107 |
GO:00096124 | Liver | HCC | response to mechanical stimulus | 113/7958 | 216/18723 | 2.20e-03 | 1.10e-02 | 113 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CNTNAP2 | SNV | Missense_Mutation | rs778901819 | c.3799G>A | p.Val1267Ile | p.V1267I | Q9UHC6 | protein_coding | tolerated(0.36) | benign(0.041) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CNTNAP2 | SNV | Missense_Mutation | c.2968G>A | p.Asp990Asn | p.D990N | Q9UHC6 | protein_coding | deleterious(0.01) | possibly_damaging(0.759) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CNTNAP2 | SNV | Missense_Mutation | c.102A>T | p.Lys34Asn | p.K34N | Q9UHC6 | protein_coding | tolerated(0.76) | benign(0.007) | TCGA-AA-3994-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | CR | |
CNTNAP2 | SNV | Missense_Mutation | c.440G>A | p.Arg147Gln | p.R147Q | Q9UHC6 | protein_coding | tolerated(0.43) | benign(0.095) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
CNTNAP2 | SNV | Missense_Mutation | c.478N>T | p.Arg160Cys | p.R160C | Q9UHC6 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AA-A02F-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | PR | |
CNTNAP2 | SNV | Missense_Mutation | c.1670N>T | p.Arg557Ile | p.R557I | Q9UHC6 | protein_coding | deleterious(0) | probably_damaging(0.923) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CNTNAP2 | SNV | Missense_Mutation | c.3007N>G | p.Lys1003Glu | p.K1003E | Q9UHC6 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CNTNAP2 | SNV | Missense_Mutation | c.2471N>A | p.Ser824Tyr | p.S824Y | Q9UHC6 | protein_coding | deleterious(0) | possibly_damaging(0.77) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CNTNAP2 | SNV | Missense_Mutation | rs367652115 | c.632N>C | p.Val211Ala | p.V211A | Q9UHC6 | protein_coding | deleterious(0.02) | benign(0.297) | TCGA-CA-5254-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CNTNAP2 | SNV | Missense_Mutation | c.260T>A | p.Val87Asp | p.V87D | Q9UHC6 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CK-5914-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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