![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CLUAP1 |
Gene summary for CLUAP1 |
![]() |
Gene information | Species | Human | Gene symbol | CLUAP1 | Gene ID | 23059 |
Gene name | clusterin associated protein 1 | |
Gene Alias | CFAP22 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | J3KNW5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23059 | CLUAP1 | LZE2T | Human | Esophagus | ESCC | 3.99e-05 | 4.87e-01 | 0.082 |
23059 | CLUAP1 | LZE4T | Human | Esophagus | ESCC | 3.14e-15 | 5.27e-01 | 0.0811 |
23059 | CLUAP1 | LZE7T | Human | Esophagus | ESCC | 2.67e-06 | 3.07e-01 | 0.0667 |
23059 | CLUAP1 | LZE8T | Human | Esophagus | ESCC | 6.25e-05 | 2.06e-01 | 0.067 |
23059 | CLUAP1 | LZE20T | Human | Esophagus | ESCC | 2.38e-03 | 1.59e-01 | 0.0662 |
23059 | CLUAP1 | LZE24T | Human | Esophagus | ESCC | 1.06e-16 | 5.18e-01 | 0.0596 |
23059 | CLUAP1 | LZE21T | Human | Esophagus | ESCC | 8.95e-09 | 5.39e-01 | 0.0655 |
23059 | CLUAP1 | P1T-E | Human | Esophagus | ESCC | 7.15e-07 | 2.68e-01 | 0.0875 |
23059 | CLUAP1 | P2T-E | Human | Esophagus | ESCC | 8.64e-66 | 1.08e+00 | 0.1177 |
23059 | CLUAP1 | P4T-E | Human | Esophagus | ESCC | 1.42e-20 | 4.91e-01 | 0.1323 |
23059 | CLUAP1 | P5T-E | Human | Esophagus | ESCC | 7.98e-26 | 4.37e-01 | 0.1327 |
23059 | CLUAP1 | P8T-E | Human | Esophagus | ESCC | 1.85e-24 | 4.98e-01 | 0.0889 |
23059 | CLUAP1 | P9T-E | Human | Esophagus | ESCC | 3.66e-22 | 4.83e-01 | 0.1131 |
23059 | CLUAP1 | P11T-E | Human | Esophagus | ESCC | 9.70e-08 | 4.75e-01 | 0.1426 |
23059 | CLUAP1 | P12T-E | Human | Esophagus | ESCC | 3.69e-71 | 1.34e+00 | 0.1122 |
23059 | CLUAP1 | P15T-E | Human | Esophagus | ESCC | 7.61e-47 | 1.07e+00 | 0.1149 |
23059 | CLUAP1 | P16T-E | Human | Esophagus | ESCC | 2.88e-22 | 4.51e-01 | 0.1153 |
23059 | CLUAP1 | P17T-E | Human | Esophagus | ESCC | 3.86e-07 | 3.45e-01 | 0.1278 |
23059 | CLUAP1 | P20T-E | Human | Esophagus | ESCC | 3.98e-13 | 3.68e-01 | 0.1124 |
23059 | CLUAP1 | P21T-E | Human | Esophagus | ESCC | 2.14e-20 | 4.26e-01 | 0.1617 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLUAP1 | SNV | Missense_Mutation | c.185N>C | p.Arg62Pro | p.R62P | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-86-8585-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
CLUAP1 | SNV | Missense_Mutation | novel | c.979N>C | p.Glu327Gln | p.E327Q | protein_coding | tolerated(0.11) | possibly_damaging(0.697) | TCGA-91-A4BC-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CLUAP1 | SNV | Missense_Mutation | c.127N>T | p.Val43Leu | p.V43L | protein_coding | tolerated(0.08) | benign(0.32) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | ||
CLUAP1 | SNV | Missense_Mutation | novel | c.555G>T | p.Met185Ile | p.M185I | protein_coding | tolerated(0.31) | benign(0) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLUAP1 | SNV | Missense_Mutation | rs750671279 | c.82N>T | p.Arg28Cys | p.R28C | protein_coding | deleterious(0) | benign(0.069) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CLUAP1 | SNV | Missense_Mutation | novel | c.505N>G | p.Thr169Ala | p.T169A | protein_coding | tolerated(0.11) | benign(0.005) | TCGA-L3-A524-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CLUAP1 | SNV | Missense_Mutation | novel | c.985N>C | p.Glu329Gln | p.E329Q | protein_coding | tolerated(0.07) | possibly_damaging(0.796) | TCGA-BB-A5HU-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
CLUAP1 | SNV | Missense_Mutation | rs528317873 | c.74N>G | p.Glu25Gly | p.E25G | protein_coding | tolerated(0.06) | probably_damaging(0.944) | TCGA-CN-4726-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD | |
CLUAP1 | SNV | Missense_Mutation | novel | c.133N>G | p.Arg45Gly | p.R45G | protein_coding | deleterious(0) | possibly_damaging(0.802) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CLUAP1 | SNV | Missense_Mutation | c.442N>G | p.Thr148Ala | p.T148A | protein_coding | deleterious(0.03) | benign(0.202) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |