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Gene: CLCN5 |
Gene summary for CLCN5 |
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Gene information | Species | Human | Gene symbol | CLCN5 | Gene ID | 1184 |
Gene name | chloride voltage-gated channel 5 | |
Gene Alias | CLC5 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | A8K4H5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1184 | CLCN5 | HCC1_Meng | Human | Liver | HCC | 3.78e-37 | 1.08e-01 | 0.0246 |
1184 | CLCN5 | HCC2 | Human | Liver | HCC | 4.65e-06 | 2.42e+00 | 0.5341 |
1184 | CLCN5 | S016 | Human | Liver | HCC | 2.65e-05 | 2.98e-01 | 0.2243 |
1184 | CLCN5 | S028 | Human | Liver | HCC | 3.50e-13 | 6.22e-01 | 0.2503 |
1184 | CLCN5 | S029 | Human | Liver | HCC | 1.43e-11 | 6.77e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19026007 | Liver | HCC | proton transmembrane transport | 87/7958 | 157/18723 | 7.27e-04 | 4.42e-03 | 87 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLCN5 | SNV | Missense_Mutation | novel | c.2066N>T | p.Gly689Val | p.G689V | P51795 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CLCN5 | SNV | Missense_Mutation | novel | c.661G>A | p.Ala221Thr | p.A221T | P51795 | protein_coding | deleterious(0.05) | benign(0.117) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLCN5 | SNV | Missense_Mutation | novel | c.1570C>A | p.Leu524Ile | p.L524I | P51795 | protein_coding | tolerated(0.13) | probably_damaging(0.986) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLCN5 | SNV | Missense_Mutation | c.1723G>A | p.Val575Ile | p.V575I | P51795 | protein_coding | tolerated(0.07) | probably_damaging(0.98) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CLCN5 | SNV | Missense_Mutation | novel | c.432G>C | p.Leu144Phe | p.L144F | P51795 | protein_coding | tolerated(0.15) | possibly_damaging(0.571) | TCGA-AJ-A3BK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLCN5 | SNV | Missense_Mutation | rs368674238 | c.689N>C | p.Val230Ala | p.V230A | P51795 | protein_coding | tolerated(0.55) | benign(0) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
CLCN5 | SNV | Missense_Mutation | novel | c.88N>A | p.Leu30Met | p.L30M | P51795 | protein_coding | tolerated_low_confidence(0.6) | benign(0.007) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLCN5 | SNV | Missense_Mutation | rs782602018 | c.1466N>T | p.Pro489Leu | p.P489L | P51795 | protein_coding | deleterious(0.02) | benign(0.039) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLCN5 | SNV | Missense_Mutation | c.1630N>A | p.Glu544Lys | p.E544K | P51795 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CLCN5 | SNV | Missense_Mutation | novel | c.544G>A | p.Glu182Lys | p.E182K | P51795 | protein_coding | tolerated(0.14) | benign(0.037) | TCGA-AJ-A3IA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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