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Gene: CLASRP |
Gene summary for CLASRP |
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Gene information | Species | Human | Gene symbol | CLASRP | Gene ID | 11129 |
Gene name | CLK4 associating serine/arginine rich protein | |
Gene Alias | CLASP | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8N2M8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11129 | CLASRP | LZE4T | Human | Esophagus | ESCC | 1.31e-10 | 2.40e-01 | 0.0811 |
11129 | CLASRP | LZE7T | Human | Esophagus | ESCC | 1.53e-04 | 3.26e-01 | 0.0667 |
11129 | CLASRP | LZE20T | Human | Esophagus | ESCC | 4.72e-03 | 1.56e-01 | 0.0662 |
11129 | CLASRP | LZE22D1 | Human | Esophagus | HGIN | 3.82e-03 | 1.87e-01 | 0.0595 |
11129 | CLASRP | LZE22T | Human | Esophagus | ESCC | 2.70e-09 | 5.47e-01 | 0.068 |
11129 | CLASRP | LZE24T | Human | Esophagus | ESCC | 9.02e-14 | 4.40e-01 | 0.0596 |
11129 | CLASRP | LZE21T | Human | Esophagus | ESCC | 1.19e-05 | 2.82e-01 | 0.0655 |
11129 | CLASRP | P1T-E | Human | Esophagus | ESCC | 2.05e-18 | 7.70e-01 | 0.0875 |
11129 | CLASRP | P2T-E | Human | Esophagus | ESCC | 4.47e-25 | 4.93e-01 | 0.1177 |
11129 | CLASRP | P4T-E | Human | Esophagus | ESCC | 1.90e-12 | 3.38e-01 | 0.1323 |
11129 | CLASRP | P5T-E | Human | Esophagus | ESCC | 3.17e-19 | 3.52e-01 | 0.1327 |
11129 | CLASRP | P8T-E | Human | Esophagus | ESCC | 2.10e-61 | 1.13e+00 | 0.0889 |
11129 | CLASRP | P9T-E | Human | Esophagus | ESCC | 1.13e-03 | 2.45e-01 | 0.1131 |
11129 | CLASRP | P10T-E | Human | Esophagus | ESCC | 2.71e-54 | 1.07e+00 | 0.116 |
11129 | CLASRP | P11T-E | Human | Esophagus | ESCC | 3.65e-12 | 5.90e-01 | 0.1426 |
11129 | CLASRP | P12T-E | Human | Esophagus | ESCC | 3.43e-30 | 5.32e-01 | 0.1122 |
11129 | CLASRP | P15T-E | Human | Esophagus | ESCC | 1.18e-31 | 6.85e-01 | 0.1149 |
11129 | CLASRP | P16T-E | Human | Esophagus | ESCC | 1.09e-17 | 3.23e-01 | 0.1153 |
11129 | CLASRP | P17T-E | Human | Esophagus | ESCC | 7.61e-09 | 2.53e-01 | 0.1278 |
11129 | CLASRP | P19T-E | Human | Esophagus | ESCC | 1.97e-05 | 3.00e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:0008380110 | Oral cavity | LP | RNA splicing | 237/4623 | 434/18723 | 1.82e-41 | 3.79e-38 | 237 |
GO:000838025 | Oral cavity | EOLP | RNA splicing | 115/2218 | 434/18723 | 2.24e-17 | 3.04e-14 | 115 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLASRP | SNV | Missense_Mutation | rs761546635 | c.1775N>T | p.Ala592Val | p.A592V | protein_coding | deleterious(0.01) | probably_damaging(0.972) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLASRP | SNV | Missense_Mutation | novel | c.883N>A | p.Pro295Thr | p.P295T | protein_coding | deleterious(0.05) | unknown(0) | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
CLASRP | SNV | Missense_Mutation | novel | c.17G>A | p.Arg6Gln | p.R6Q | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
CLASRP | SNV | Missense_Mutation | c.905G>A | p.Arg302Gln | p.R302Q | protein_coding | tolerated(0.09) | unknown(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
CLASRP | SNV | Missense_Mutation | c.490G>A | p.Gly164Ser | p.G164S | protein_coding | deleterious(0.03) | unknown(0) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CLASRP | SNV | Missense_Mutation | c.317N>T | p.Ser106Leu | p.S106L | protein_coding | tolerated(0.2) | benign(0.063) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CLASRP | SNV | Missense_Mutation | novel | c.16N>T | p.Arg6Trp | p.R6W | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AX-A1C4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CLASRP | SNV | Missense_Mutation | novel | c.1718N>T | p.Thr573Met | p.T573M | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AX-A1C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLASRP | SNV | Missense_Mutation | rs139553242 | c.469N>A | p.Ala157Thr | p.A157T | protein_coding | deleterious(0.01) | unknown(0) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CLASRP | SNV | Missense_Mutation | novel | c.1915N>T | p.Arg639Cys | p.R639C | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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