![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CHI3L1 |
Gene summary for CHI3L1 |
![]() |
Gene information | Species | Human | Gene symbol | CHI3L1 | Gene ID | 1116 |
Gene name | chitinase 3 like 1 | |
Gene Alias | ASRT7 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024R969 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1116 | CHI3L1 | GSM4909282 | Human | Breast | IDC | 3.58e-12 | 3.25e-01 | -0.0288 |
1116 | CHI3L1 | GSM4909285 | Human | Breast | IDC | 4.46e-04 | -2.30e-01 | 0.21 |
1116 | CHI3L1 | GSM4909286 | Human | Breast | IDC | 1.76e-12 | -4.27e-01 | 0.1081 |
1116 | CHI3L1 | GSM4909290 | Human | Breast | IDC | 3.77e-08 | -4.27e-01 | 0.2096 |
1116 | CHI3L1 | GSM4909291 | Human | Breast | IDC | 2.68e-08 | -4.33e-01 | 0.1753 |
1116 | CHI3L1 | GSM4909293 | Human | Breast | IDC | 6.19e-04 | -3.36e-01 | 0.1581 |
1116 | CHI3L1 | GSM4909294 | Human | Breast | IDC | 5.36e-13 | -4.02e-01 | 0.2022 |
1116 | CHI3L1 | GSM4909296 | Human | Breast | IDC | 5.75e-12 | -4.29e-01 | 0.1524 |
1116 | CHI3L1 | GSM4909297 | Human | Breast | IDC | 9.60e-13 | -4.12e-01 | 0.1517 |
1116 | CHI3L1 | GSM4909298 | Human | Breast | IDC | 1.81e-04 | -3.44e-01 | 0.1551 |
1116 | CHI3L1 | GSM4909299 | Human | Breast | IDC | 8.97e-06 | 5.51e-01 | 0.035 |
1116 | CHI3L1 | GSM4909301 | Human | Breast | IDC | 2.12e-16 | -4.33e-01 | 0.1577 |
1116 | CHI3L1 | GSM4909302 | Human | Breast | IDC | 1.05e-08 | -3.98e-01 | 0.1545 |
1116 | CHI3L1 | GSM4909304 | Human | Breast | IDC | 1.17e-02 | -3.11e-01 | 0.1636 |
1116 | CHI3L1 | GSM4909308 | Human | Breast | IDC | 2.56e-06 | -3.95e-01 | 0.158 |
1116 | CHI3L1 | GSM4909311 | Human | Breast | IDC | 3.34e-08 | -3.63e-01 | 0.1534 |
1116 | CHI3L1 | GSM4909312 | Human | Breast | IDC | 1.44e-09 | -4.16e-01 | 0.1552 |
1116 | CHI3L1 | GSM4909313 | Human | Breast | IDC | 2.89e-02 | 4.26e-01 | 0.0391 |
1116 | CHI3L1 | GSM4909315 | Human | Breast | IDC | 4.80e-16 | -4.31e-01 | 0.21 |
1116 | CHI3L1 | GSM4909316 | Human | Breast | IDC | 2.04e-03 | -4.33e-01 | 0.21 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00018196 | Breast | Precancer | positive regulation of cytokine production | 52/1080 | 467/18723 | 4.18e-06 | 1.29e-04 | 52 |
GO:00713568 | Breast | Precancer | cellular response to tumor necrosis factor | 28/1080 | 229/18723 | 1.42e-04 | 2.45e-03 | 28 |
GO:0045766 | Breast | Precancer | positive regulation of angiogenesis | 23/1080 | 181/18723 | 3.09e-04 | 4.43e-03 | 23 |
GO:1904018 | Breast | Precancer | positive regulation of vasculature development | 23/1080 | 181/18723 | 3.09e-04 | 4.43e-03 | 23 |
GO:00346128 | Breast | Precancer | response to tumor necrosis factor | 29/1080 | 253/18723 | 3.32e-04 | 4.70e-03 | 29 |
GO:0045765 | Breast | Precancer | regulation of angiogenesis | 35/1080 | 342/18723 | 7.35e-04 | 8.80e-03 | 35 |
GO:1901342 | Breast | Precancer | regulation of vasculature development | 35/1080 | 348/18723 | 1.00e-03 | 1.12e-02 | 35 |
GO:00434912 | Breast | Precancer | protein kinase B signaling | 23/1080 | 211/18723 | 2.53e-03 | 2.30e-02 | 23 |
GO:00336749 | Breast | Precancer | positive regulation of kinase activity | 42/1080 | 467/18723 | 2.94e-03 | 2.54e-02 | 42 |
GO:00096126 | Breast | Precancer | response to mechanical stimulus | 23/1080 | 216/18723 | 3.41e-03 | 2.85e-02 | 23 |
GO:000181911 | Breast | IDC | positive regulation of cytokine production | 61/1434 | 467/18723 | 2.81e-05 | 6.58e-04 | 61 |
GO:000961211 | Breast | IDC | response to mechanical stimulus | 34/1434 | 216/18723 | 4.59e-05 | 1.03e-03 | 34 |
GO:007135613 | Breast | IDC | cellular response to tumor necrosis factor | 35/1434 | 229/18723 | 6.64e-05 | 1.35e-03 | 35 |
GO:00303244 | Breast | IDC | lung development | 28/1434 | 177/18723 | 1.90e-04 | 3.15e-03 | 28 |
GO:003461213 | Breast | IDC | response to tumor necrosis factor | 36/1434 | 253/18723 | 2.29e-04 | 3.64e-03 | 36 |
GO:00457651 | Breast | IDC | regulation of angiogenesis | 45/1434 | 342/18723 | 2.57e-04 | 3.98e-03 | 45 |
GO:00303234 | Breast | IDC | respiratory tube development | 28/1434 | 181/18723 | 2.78e-04 | 4.26e-03 | 28 |
GO:19013421 | Breast | IDC | regulation of vasculature development | 45/1434 | 348/18723 | 3.78e-04 | 5.38e-03 | 45 |
GO:00605412 | Breast | IDC | respiratory system development | 30/1434 | 203/18723 | 3.85e-04 | 5.40e-03 | 30 |
GO:00703713 | Breast | IDC | ERK1 and ERK2 cascade | 43/1434 | 330/18723 | 4.28e-04 | 5.84e-03 | 43 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHI3L1 | SNV | Missense_Mutation | c.1098N>T | p.Gln366His | p.Q366H | P36222 | protein_coding | deleterious(0.02) | benign(0.006) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHI3L1 | SNV | Missense_Mutation | rs527531482 | c.1040N>T | p.Ala347Val | p.A347V | P36222 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-D1-A16R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHI3L1 | SNV | Missense_Mutation | rs544815237 | c.284N>A | p.Ser95Tyr | p.S95Y | P36222 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHI3L1 | SNV | Missense_Mutation | novel | c.252G>T | p.Lys84Asn | p.K84N | P36222 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
CHI3L1 | SNV | Missense_Mutation | novel | c.226N>T | p.Leu76Phe | p.L76F | P36222 | protein_coding | tolerated(0.06) | probably_damaging(0.972) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CHI3L1 | SNV | Missense_Mutation | rs201313181 | c.1105C>T | p.Arg369Cys | p.R369C | P36222 | protein_coding | deleterious(0.01) | benign(0.327) | TCGA-EY-A5W2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHI3L1 | SNV | Missense_Mutation | novel | c.176N>T | p.Ala59Val | p.A59V | P36222 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-44-7659-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CHI3L1 | SNV | Missense_Mutation | rs138989209 | c.856N>T | p.Arg286Trp | p.R286W | P36222 | protein_coding | deleterious(0) | possibly_damaging(0.723) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
CHI3L1 | SNV | Missense_Mutation | c.223N>T | p.Thr75Ser | p.T75S | P36222 | protein_coding | tolerated(0.24) | benign(0.003) | TCGA-55-7903-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CHI3L1 | SNV | Missense_Mutation | c.636N>C | p.Trp212Cys | p.W212C | P36222 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-91-6848-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1116 | CHI3L1 | CELL SURFACE, DRUGGABLE GENOME | ANTI-INFLAMMATORY DRUGS | 16035398 | ||
1116 | CHI3L1 | CELL SURFACE, DRUGGABLE GENOME | CHEMOKINES | 15015934 |
Page: 1 |