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Gene: CFAP97 |
Gene summary for CFAP97 |
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Gene information | Species | Human | Gene symbol | CFAP97 | Gene ID | 57587 |
Gene name | cilia and flagella associated protein 97 | |
Gene Alias | KIAA1430 | |
Cytomap | 4q35.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q9P2B7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57587 | CFAP97 | LZE2T | Human | Esophagus | ESCC | 1.15e-05 | 3.65e-01 | 0.082 |
57587 | CFAP97 | LZE3D | Human | Esophagus | HGIN | 2.59e-03 | 4.84e-01 | 0.0668 |
57587 | CFAP97 | LZE4T | Human | Esophagus | ESCC | 2.52e-14 | 5.15e-01 | 0.0811 |
57587 | CFAP97 | LZE7T | Human | Esophagus | ESCC | 2.06e-04 | 1.83e-01 | 0.0667 |
57587 | CFAP97 | LZE8T | Human | Esophagus | ESCC | 3.45e-04 | 7.77e-02 | 0.067 |
57587 | CFAP97 | LZE22T | Human | Esophagus | ESCC | 1.21e-03 | 1.51e-01 | 0.068 |
57587 | CFAP97 | LZE24T | Human | Esophagus | ESCC | 3.98e-08 | 2.54e-01 | 0.0596 |
57587 | CFAP97 | LZE21T | Human | Esophagus | ESCC | 8.25e-03 | 1.99e-01 | 0.0655 |
57587 | CFAP97 | P1T-E | Human | Esophagus | ESCC | 2.55e-07 | 4.25e-01 | 0.0875 |
57587 | CFAP97 | P2T-E | Human | Esophagus | ESCC | 5.86e-45 | 9.35e-01 | 0.1177 |
57587 | CFAP97 | P4T-E | Human | Esophagus | ESCC | 1.30e-27 | 6.94e-01 | 0.1323 |
57587 | CFAP97 | P5T-E | Human | Esophagus | ESCC | 1.22e-23 | 5.76e-01 | 0.1327 |
57587 | CFAP97 | P8T-E | Human | Esophagus | ESCC | 2.76e-18 | 3.51e-01 | 0.0889 |
57587 | CFAP97 | P9T-E | Human | Esophagus | ESCC | 8.91e-13 | 3.62e-01 | 0.1131 |
57587 | CFAP97 | P10T-E | Human | Esophagus | ESCC | 8.79e-17 | 3.79e-01 | 0.116 |
57587 | CFAP97 | P11T-E | Human | Esophagus | ESCC | 5.60e-15 | 3.65e-01 | 0.1426 |
57587 | CFAP97 | P12T-E | Human | Esophagus | ESCC | 2.08e-31 | 7.46e-01 | 0.1122 |
57587 | CFAP97 | P15T-E | Human | Esophagus | ESCC | 1.52e-23 | 4.78e-01 | 0.1149 |
57587 | CFAP97 | P16T-E | Human | Esophagus | ESCC | 5.84e-45 | 8.82e-01 | 0.1153 |
57587 | CFAP97 | P17T-E | Human | Esophagus | ESCC | 9.88e-05 | 3.28e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP97 | SNV | Missense_Mutation | novel | c.1315A>C | p.Asn439His | p.N439H | Q9P2B7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CFAP97 | SNV | Missense_Mutation | rs368433789 | c.599C>T | p.Ser200Leu | p.S200L | Q9P2B7 | protein_coding | tolerated(0.08) | benign(0.019) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CFAP97 | SNV | Missense_Mutation | novel | c.429N>T | p.Lys143Asn | p.K143N | Q9P2B7 | protein_coding | deleterious(0) | benign(0.444) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CFAP97 | SNV | Missense_Mutation | rs758433480 | c.1556G>A | p.Arg519Gln | p.R519Q | Q9P2B7 | protein_coding | deleterious(0) | benign(0.067) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CFAP97 | SNV | Missense_Mutation | novel | c.366N>C | p.Lys122Asn | p.K122N | Q9P2B7 | protein_coding | deleterious(0.01) | benign(0.116) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CFAP97 | SNV | Missense_Mutation | rs373566490 | c.158N>T | p.Ser53Leu | p.S53L | Q9P2B7 | protein_coding | tolerated(0.61) | benign(0) | TCGA-EY-A1GD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CFAP97 | SNV | Missense_Mutation | novel | c.429N>T | p.Lys143Asn | p.K143N | Q9P2B7 | protein_coding | deleterious(0) | benign(0.444) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
CFAP97 | insertion | In_Frame_Ins | novel | c.412_413insCAACAAAAAAGGTAACTCAGT | p.Ser138delinsThrThrLysLysValThrGlnCys | p.S138delinsTTKKVTQC | Q9P2B7 | protein_coding | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CFAP97 | deletion | Frame_Shift_Del | novel | c.481delN | p.Ser161AlafsTer2 | p.S161Afs*2 | Q9P2B7 | protein_coding | TCGA-D1-A174-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CFAP97 | deletion | Frame_Shift_Del | novel | c.930delN | p.Glu313LysfsTer15 | p.E313Kfs*15 | Q9P2B7 | protein_coding | TCGA-DI-A0WH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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