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Gene: CEP85L |
Gene summary for CEP85L |
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Gene information | Species | Human | Gene symbol | CEP85L | Gene ID | 387119 |
Gene name | centrosomal protein 85 like | |
Gene Alias | C6orf204 | |
Cytomap | 6q22.31 | |
Gene Type | protein-coding | GO ID | GO:0001764 | UniProtAcc | Q3ZCQ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
387119 | CEP85L | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.29e-10 | 1.22e-01 | 0.0155 |
387119 | CEP85L | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.19e-03 | 2.08e-01 | -0.1808 |
387119 | CEP85L | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.15e-09 | 2.67e-01 | -0.0811 |
387119 | CEP85L | HTA11_347_2000001011 | Human | Colorectum | AD | 3.87e-04 | 9.01e-02 | -0.1954 |
387119 | CEP85L | HTA11_411_2000001011 | Human | Colorectum | SER | 3.74e-03 | 3.26e-01 | -0.2602 |
387119 | CEP85L | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.61e-04 | 3.83e-01 | -0.2196 |
387119 | CEP85L | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.96e-06 | 2.57e-01 | -0.1207 |
387119 | CEP85L | HTA11_83_2000001011 | Human | Colorectum | SER | 4.56e-04 | 1.76e-01 | -0.1526 |
387119 | CEP85L | HTA11_696_2000001011 | Human | Colorectum | AD | 4.00e-21 | 4.38e-01 | -0.1464 |
387119 | CEP85L | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.29e-17 | 4.31e-01 | -0.059 |
387119 | CEP85L | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.84e-06 | 3.14e-01 | -0.1706 |
387119 | CEP85L | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.49e-02 | 1.73e-01 | -0.2061 |
387119 | CEP85L | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.17e-08 | 4.73e-01 | -0.1462 |
387119 | CEP85L | HTA11_546_2000001011 | Human | Colorectum | AD | 4.57e-08 | 2.91e-01 | -0.0842 |
387119 | CEP85L | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.69e-02 | 2.14e-01 | 0.0112 |
387119 | CEP85L | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.86e-05 | 2.00e-01 | 0.0588 |
387119 | CEP85L | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.30e-03 | 9.85e-02 | 0.294 |
387119 | CEP85L | PTC04 | Human | Thyroid | PTC | 1.97e-02 | 6.04e-02 | 0.1927 |
387119 | CEP85L | PTC06 | Human | Thyroid | PTC | 3.76e-03 | 1.53e-01 | 0.2057 |
387119 | CEP85L | PTC07 | Human | Thyroid | PTC | 1.25e-05 | 1.07e-01 | 0.2044 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEP85L | deletion | Frame_Shift_Del | rs776770568 | c.427delN | p.Glu143SerfsTer6 | p.E143Sfs*6 | Q5SZL2 | protein_coding | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
CEP85L | deletion | Frame_Shift_Del | c.672delA | p.Lys224AsnfsTer32 | p.K224Nfs*32 | Q5SZL2 | protein_coding | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
CEP85L | SNV | Missense_Mutation | novel | c.470N>A | p.Arg157Gln | p.R157Q | Q5SZL2 | protein_coding | deleterious(0.05) | probably_damaging(0.928) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CEP85L | SNV | Missense_Mutation | novel | c.241N>T | p.Asp81Tyr | p.D81Y | Q5SZL2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CEP85L | SNV | Missense_Mutation | novel | c.2079N>T | p.Gln693His | p.Q693H | Q5SZL2 | protein_coding | tolerated(0.58) | benign(0.006) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
CEP85L | SNV | Missense_Mutation | novel | c.1661N>C | p.Lys554Thr | p.K554T | Q5SZL2 | protein_coding | tolerated(0.2) | benign(0.036) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CEP85L | SNV | Missense_Mutation | rs371962633 | c.158N>A | p.Arg53Gln | p.R53Q | Q5SZL2 | protein_coding | tolerated(0.45) | benign(0.142) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CEP85L | SNV | Missense_Mutation | novel | c.701A>C | p.Lys234Thr | p.K234T | Q5SZL2 | protein_coding | tolerated(0.06) | probably_damaging(0.983) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CEP85L | SNV | Missense_Mutation | c.383G>T | p.Trp128Leu | p.W128L | Q5SZL2 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CEP85L | SNV | Missense_Mutation | c.1115N>A | p.Gly372Glu | p.G372E | Q5SZL2 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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