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Gene: CEP295 |
Gene summary for CEP295 |
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Gene information | Species | Human | Gene symbol | CEP295 | Gene ID | 85459 |
Gene name | centrosomal protein 295 | |
Gene Alias | KIAA1731 | |
Cytomap | 11q21 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q9C0D2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85459 | CEP295 | HCC1_Meng | Human | Liver | HCC | 1.00e-31 | 2.08e-02 | 0.0246 |
85459 | CEP295 | HCC2_Meng | Human | Liver | HCC | 1.72e-03 | 1.93e-02 | 0.0107 |
85459 | CEP295 | HCC1 | Human | Liver | HCC | 8.86e-03 | 3.98e+00 | 0.5336 |
85459 | CEP295 | HCC2 | Human | Liver | HCC | 3.77e-14 | 4.02e+00 | 0.5341 |
85459 | CEP295 | S016 | Human | Liver | HCC | 1.22e-02 | 2.70e-01 | 0.2243 |
85459 | CEP295 | S027 | Human | Liver | HCC | 4.13e-06 | 5.42e-01 | 0.2446 |
85459 | CEP295 | S028 | Human | Liver | HCC | 8.72e-06 | 4.36e-01 | 0.2503 |
85459 | CEP295 | S029 | Human | Liver | HCC | 1.54e-04 | 3.50e-01 | 0.2581 |
85459 | CEP295 | male-WTA | Human | Thyroid | PTC | 1.68e-02 | 8.84e-02 | 0.1037 |
85459 | CEP295 | PTC01 | Human | Thyroid | PTC | 1.66e-02 | 1.12e-01 | 0.1899 |
85459 | CEP295 | PTC03 | Human | Thyroid | PTC | 4.63e-02 | 1.61e-01 | 0.1784 |
85459 | CEP295 | PTC04 | Human | Thyroid | PTC | 6.76e-10 | 1.69e-01 | 0.1927 |
85459 | CEP295 | PTC05 | Human | Thyroid | PTC | 7.62e-15 | 5.16e-01 | 0.2065 |
85459 | CEP295 | PTC06 | Human | Thyroid | PTC | 3.50e-21 | 5.08e-01 | 0.2057 |
85459 | CEP295 | PTC07 | Human | Thyroid | PTC | 7.21e-18 | 3.38e-01 | 0.2044 |
85459 | CEP295 | ATC12 | Human | Thyroid | ATC | 2.65e-19 | 4.37e-01 | 0.34 |
85459 | CEP295 | ATC13 | Human | Thyroid | ATC | 2.49e-19 | 2.22e-01 | 0.34 |
85459 | CEP295 | ATC2 | Human | Thyroid | ATC | 5.89e-12 | 7.75e-01 | 0.34 |
85459 | CEP295 | ATC4 | Human | Thyroid | ATC | 4.51e-23 | 5.58e-01 | 0.34 |
85459 | CEP295 | ATC5 | Human | Thyroid | ATC | 1.51e-16 | 2.46e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190495122 | Liver | HCC | positive regulation of establishment of protein localization | 207/7958 | 319/18723 | 3.95e-16 | 3.29e-14 | 207 |
GO:00064732 | Liver | HCC | protein acetylation | 135/7958 | 201/18723 | 1.20e-12 | 5.92e-11 | 135 |
GO:00435432 | Liver | HCC | protein acylation | 157/7958 | 243/18723 | 2.40e-12 | 1.12e-10 | 157 |
GO:005149522 | Liver | HCC | positive regulation of cytoskeleton organization | 138/7958 | 226/18723 | 1.26e-08 | 3.12e-07 | 138 |
GO:19021151 | Liver | HCC | regulation of organelle assembly | 110/7958 | 186/18723 | 3.30e-06 | 4.34e-05 | 110 |
GO:004578711 | Liver | HCC | positive regulation of cell cycle | 172/7958 | 313/18723 | 5.29e-06 | 6.58e-05 | 172 |
GO:0031023 | Liver | HCC | microtubule organizing center organization | 82/7958 | 143/18723 | 2.38e-04 | 1.79e-03 | 82 |
GO:0007098 | Liver | HCC | centrosome cycle | 75/7958 | 130/18723 | 3.33e-04 | 2.34e-03 | 75 |
GO:19019831 | Liver | HCC | regulation of protein acetylation | 48/7958 | 77/18723 | 3.49e-04 | 2.43e-03 | 48 |
GO:00900683 | Liver | HCC | positive regulation of cell cycle process | 125/7958 | 236/18723 | 7.21e-04 | 4.40e-03 | 125 |
GO:1902117 | Liver | HCC | positive regulation of organelle assembly | 41/7958 | 67/18723 | 1.55e-03 | 8.20e-03 | 41 |
GO:0032886 | Liver | HCC | regulation of microtubule-based process | 123/7958 | 240/18723 | 3.69e-03 | 1.64e-02 | 123 |
GO:00466052 | Liver | HCC | regulation of centrosome cycle | 30/7958 | 49/18723 | 6.31e-03 | 2.57e-02 | 30 |
GO:1901985 | Liver | HCC | positive regulation of protein acetylation | 27/7958 | 45/18723 | 1.35e-02 | 4.80e-02 | 27 |
GO:1904951113 | Thyroid | PTC | positive regulation of establishment of protein localization | 175/5968 | 319/18723 | 1.10e-17 | 1.12e-15 | 175 |
GO:00064737 | Thyroid | PTC | protein acetylation | 116/5968 | 201/18723 | 3.05e-14 | 1.92e-12 | 116 |
GO:00435437 | Thyroid | PTC | protein acylation | 134/5968 | 243/18723 | 4.22e-14 | 2.58e-12 | 134 |
GO:005149526 | Thyroid | PTC | positive regulation of cytoskeleton organization | 121/5968 | 226/18723 | 1.04e-11 | 4.27e-10 | 121 |
GO:004578718 | Thyroid | PTC | positive regulation of cell cycle | 144/5968 | 313/18723 | 9.93e-08 | 1.99e-06 | 144 |
GO:19019837 | Thyroid | PTC | regulation of protein acetylation | 46/5968 | 77/18723 | 4.26e-07 | 7.03e-06 | 46 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEP295 | SNV | Missense_Mutation | novel | c.7455N>C | p.Lys2485Asn | p.K2485N | Q9C0D2 | protein_coding | deleterious(0.01) | possibly_damaging(0.66) | TCGA-LP-A4AW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CEP295 | SNV | Missense_Mutation | c.2951N>A | p.Arg984Lys | p.R984K | Q9C0D2 | protein_coding | tolerated(0.51) | benign(0) | TCGA-RA-A741-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
CEP295 | SNV | Missense_Mutation | novel | c.7725N>C | p.Glu2575Asp | p.E2575D | Q9C0D2 | protein_coding | tolerated(0.24) | benign(0.015) | TCGA-VS-A8EH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
CEP295 | SNV | Missense_Mutation | novel | c.6173T>C | p.Ile2058Thr | p.I2058T | Q9C0D2 | protein_coding | tolerated(0.27) | benign(0.003) | TCGA-VS-A9UL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
CEP295 | SNV | Missense_Mutation | rs183120281 | c.7602A>T | p.Lys2534Asn | p.K2534N | Q9C0D2 | protein_coding | deleterious(0.03) | possibly_damaging(0.868) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
CEP295 | SNV | Missense_Mutation | c.3833A>C | p.Gln1278Pro | p.Q1278P | Q9C0D2 | protein_coding | tolerated(0.11) | benign(0.011) | TCGA-AA-3496-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CEP295 | SNV | Missense_Mutation | c.1400N>T | p.Ser467Leu | p.S467L | Q9C0D2 | protein_coding | tolerated(0.65) | benign(0.01) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CEP295 | SNV | Missense_Mutation | novel | c.6677T>C | p.Val2226Ala | p.V2226A | Q9C0D2 | protein_coding | tolerated(0.07) | benign(0.037) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CEP295 | SNV | Missense_Mutation | rs756673379 | c.5843A>G | p.Asp1948Gly | p.D1948G | Q9C0D2 | protein_coding | deleterious(0.04) | benign(0.01) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
CEP295 | SNV | Missense_Mutation | novel | c.4530N>C | p.Gln1510His | p.Q1510H | Q9C0D2 | protein_coding | deleterious(0.04) | possibly_damaging(0.568) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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