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Gene: CDT1 |
Gene summary for CDT1 |
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Gene information | Species | Human | Gene symbol | CDT1 | Gene ID | 81620 |
Gene name | chromatin licensing and DNA replication factor 1 | |
Gene Alias | DUP | |
Cytomap | 16q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q9H211 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81620 | CDT1 | P1T-E | Human | Esophagus | ESCC | 9.99e-03 | 3.60e-01 | 0.0875 |
81620 | CDT1 | P2T-E | Human | Esophagus | ESCC | 3.24e-19 | 6.20e-01 | 0.1177 |
81620 | CDT1 | P4T-E | Human | Esophagus | ESCC | 1.83e-16 | 5.22e-01 | 0.1323 |
81620 | CDT1 | P5T-E | Human | Esophagus | ESCC | 1.73e-35 | 7.31e-01 | 0.1327 |
81620 | CDT1 | P8T-E | Human | Esophagus | ESCC | 1.21e-20 | 5.12e-01 | 0.0889 |
81620 | CDT1 | P10T-E | Human | Esophagus | ESCC | 2.57e-02 | 9.82e-02 | 0.116 |
81620 | CDT1 | P12T-E | Human | Esophagus | ESCC | 7.00e-03 | 1.58e-01 | 0.1122 |
81620 | CDT1 | P15T-E | Human | Esophagus | ESCC | 7.75e-12 | 4.68e-01 | 0.1149 |
81620 | CDT1 | P16T-E | Human | Esophagus | ESCC | 3.39e-05 | 2.49e-01 | 0.1153 |
81620 | CDT1 | P17T-E | Human | Esophagus | ESCC | 1.39e-07 | 6.93e-01 | 0.1278 |
81620 | CDT1 | P21T-E | Human | Esophagus | ESCC | 5.55e-07 | 2.02e-01 | 0.1617 |
81620 | CDT1 | P22T-E | Human | Esophagus | ESCC | 2.80e-07 | 2.81e-01 | 0.1236 |
81620 | CDT1 | P23T-E | Human | Esophagus | ESCC | 1.00e-07 | 4.10e-01 | 0.108 |
81620 | CDT1 | P24T-E | Human | Esophagus | ESCC | 4.01e-18 | 5.36e-01 | 0.1287 |
81620 | CDT1 | P26T-E | Human | Esophagus | ESCC | 1.60e-10 | 4.31e-01 | 0.1276 |
81620 | CDT1 | P27T-E | Human | Esophagus | ESCC | 3.93e-06 | 1.94e-01 | 0.1055 |
81620 | CDT1 | P28T-E | Human | Esophagus | ESCC | 3.86e-18 | 4.65e-01 | 0.1149 |
81620 | CDT1 | P31T-E | Human | Esophagus | ESCC | 1.41e-30 | 8.94e-01 | 0.1251 |
81620 | CDT1 | P32T-E | Human | Esophagus | ESCC | 1.94e-21 | 4.73e-01 | 0.1666 |
81620 | CDT1 | P37T-E | Human | Esophagus | ESCC | 2.77e-07 | 3.34e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:1903829111 | Esophagus | ESCC | positive regulation of cellular protein localization | 199/8552 | 276/18723 | 2.99e-19 | 3.45e-17 | 199 |
GO:003304416 | Esophagus | ESCC | regulation of chromosome organization | 145/8552 | 187/18723 | 3.80e-19 | 4.31e-17 | 145 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:0031334111 | Esophagus | ESCC | positive regulation of protein-containing complex assembly | 166/8552 | 237/18723 | 2.06e-14 | 1.07e-12 | 166 |
GO:005131011 | Esophagus | ESCC | metaphase plate congression | 58/8552 | 65/18723 | 1.81e-13 | 8.63e-12 | 58 |
GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
GO:000708011 | Esophagus | ESCC | mitotic metaphase plate congression | 47/8552 | 50/18723 | 3.15e-13 | 1.47e-11 | 47 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:005130311 | Esophagus | ESCC | establishment of chromosome localization | 67/8552 | 80/18723 | 1.92e-12 | 8.09e-11 | 67 |
GO:005000011 | Esophagus | ESCC | chromosome localization | 68/8552 | 82/18723 | 3.37e-12 | 1.32e-10 | 68 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa041102 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa041103 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDT1 | SNV | Missense_Mutation | novel | c.304A>C | p.Thr102Pro | p.T102P | Q9H211 | protein_coding | tolerated(0.14) | benign(0.099) | TCGA-39-5011-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
CDT1 | SNV | Missense_Mutation | rs780790780 | c.281N>T | p.Pro94Leu | p.P94L | Q9H211 | protein_coding | tolerated(0.52) | benign(0) | TCGA-39-5040-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD |
CDT1 | SNV | Missense_Mutation | rs200199040 | c.1325N>T | p.Pro442Leu | p.P442L | Q9H211 | protein_coding | deleterious(0) | possibly_damaging(0.803) | TCGA-85-8288-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CDT1 | SNV | Missense_Mutation | rs764961494 | c.374N>T | p.Ser125Leu | p.S125L | Q9H211 | protein_coding | tolerated(0.14) | benign(0.019) | TCGA-CQ-6219-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CDT1 | SNV | Missense_Mutation | rs758722232 | c.1390N>A | p.Val464Ile | p.V464I | Q9H211 | protein_coding | tolerated(0.31) | benign(0.006) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
CDT1 | SNV | Missense_Mutation | c.1544T>C | p.Ile515Thr | p.I515T | Q9H211 | protein_coding | deleterious(0.01) | possibly_damaging(0.634) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CDT1 | SNV | Missense_Mutation | rs146872515 | c.638N>T | p.Thr213Met | p.T213M | Q9H211 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CDT1 | SNV | Missense_Mutation | c.497A>C | p.Lys166Thr | p.K166T | Q9H211 | protein_coding | deleterious(0) | benign(0.165) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
CDT1 | SNV | Missense_Mutation | c.1558T>C | p.Tyr520His | p.Y520H | Q9H211 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
CDT1 | SNV | Missense_Mutation | rs528610361 | c.1378N>A | p.Val460Met | p.V460M | Q9H211 | protein_coding | deleterious(0) | benign(0.29) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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