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Gene: CDK13 |
Gene summary for CDK13 |
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Gene information | Species | Human | Gene symbol | CDK13 | Gene ID | 8621 |
Gene name | cyclin dependent kinase 13 | |
Gene Alias | CDC2L | |
Cytomap | 7p14.1 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | A0A024RA85 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8621 | CDK13 | CCI_1 | Human | Cervix | CC | 1.78e-02 | 8.73e-01 | 0.528 |
8621 | CDK13 | CCI_2 | Human | Cervix | CC | 9.89e-12 | 1.30e+00 | 0.5249 |
8621 | CDK13 | CCI_3 | Human | Cervix | CC | 9.73e-05 | 7.08e-01 | 0.516 |
8621 | CDK13 | sample3 | Human | Cervix | CC | 3.17e-06 | 2.67e-01 | 0.1387 |
8621 | CDK13 | T3 | Human | Cervix | CC | 1.27e-04 | 2.39e-01 | 0.1389 |
8621 | CDK13 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.77e-13 | -4.72e-01 | 0.0155 |
8621 | CDK13 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.73e-09 | 4.95e-01 | -0.1954 |
8621 | CDK13 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.55e-02 | -4.86e-01 | -0.1706 |
8621 | CDK13 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.72e-03 | -5.75e-01 | -0.1462 |
8621 | CDK13 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.48e-03 | -2.78e-01 | 0.0674 |
8621 | CDK13 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.35e-03 | -2.76e-01 | 0.294 |
8621 | CDK13 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.07e-03 | 5.19e-01 | 0.3487 |
8621 | CDK13 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.61e-11 | -4.52e-01 | 0.3005 |
8621 | CDK13 | A015-C-203 | Human | Colorectum | FAP | 9.02e-40 | -4.78e-01 | -0.1294 |
8621 | CDK13 | A015-C-204 | Human | Colorectum | FAP | 1.03e-07 | -4.07e-01 | -0.0228 |
8621 | CDK13 | A014-C-040 | Human | Colorectum | FAP | 2.08e-08 | -6.86e-01 | -0.1184 |
8621 | CDK13 | A002-C-201 | Human | Colorectum | FAP | 3.06e-18 | -4.38e-01 | 0.0324 |
8621 | CDK13 | A002-C-203 | Human | Colorectum | FAP | 1.03e-03 | -4.38e-04 | 0.2786 |
8621 | CDK13 | A001-C-119 | Human | Colorectum | FAP | 1.22e-09 | -4.29e-01 | -0.1557 |
8621 | CDK13 | A001-C-108 | Human | Colorectum | FAP | 1.33e-20 | -2.93e-01 | -0.0272 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00073466 | Cervix | CC | regulation of mitotic cell cycle | 88/2311 | 457/18723 | 1.26e-05 | 2.60e-04 | 88 |
GO:20007362 | Cervix | CC | regulation of stem cell differentiation | 19/2311 | 58/18723 | 4.01e-05 | 6.21e-04 | 19 |
GO:00488634 | Cervix | CC | stem cell differentiation | 46/2311 | 206/18723 | 4.11e-05 | 6.36e-04 | 46 |
GO:20007372 | Cervix | CC | negative regulation of stem cell differentiation | 10/2311 | 23/18723 | 2.00e-04 | 2.29e-03 | 10 |
GO:000838010 | Cervix | CC | RNA splicing | 76/2311 | 434/18723 | 9.79e-04 | 8.19e-03 | 76 |
GO:00063684 | Cervix | CC | transcription elongation from RNA polymerase II promoter | 17/2311 | 69/18723 | 3.65e-03 | 2.33e-02 | 17 |
GO:000037710 | Cervix | CC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 55/2311 | 320/18723 | 6.71e-03 | 3.70e-02 | 55 |
GO:000039810 | Cervix | CC | mRNA splicing, via spliceosome | 55/2311 | 320/18723 | 6.71e-03 | 3.70e-02 | 55 |
GO:00063545 | Cervix | CC | DNA-templated transcription, elongation | 20/2311 | 91/18723 | 6.88e-03 | 3.74e-02 | 20 |
GO:01400143 | Cervix | CC | mitotic nuclear division | 50/2311 | 287/18723 | 7.27e-03 | 3.91e-02 | 50 |
GO:000037510 | Cervix | CC | RNA splicing, via transesterification reactions | 55/2311 | 324/18723 | 8.61e-03 | 4.44e-02 | 55 |
GO:00482851 | Cervix | CC | organelle fission | 78/2311 | 488/18723 | 9.70e-03 | 4.79e-02 | 78 |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:0000380 | Colorectum | AD | alternative mRNA splicing, via spliceosome | 33/3918 | 77/18723 | 1.13e-05 | 2.55e-04 | 33 |
GO:0032786 | Colorectum | AD | positive regulation of DNA-templated transcription, elongation | 13/3918 | 27/18723 | 1.47e-03 | 1.25e-02 | 13 |
GO:0006354 | Colorectum | AD | DNA-templated transcription, elongation | 31/3918 | 91/18723 | 2.46e-03 | 1.90e-02 | 31 |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDK13 | SNV | Missense_Mutation | rs761752355 | c.2639N>A | p.Arg880His | p.R880H | Q14004 | protein_coding | deleterious(0.01) | possibly_damaging(0.868) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
CDK13 | SNV | Missense_Mutation | c.3745N>G | p.Pro1249Ala | p.P1249A | Q14004 | protein_coding | tolerated_low_confidence(0.11) | benign(0.012) | TCGA-G4-6323-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CDK13 | SNV | Missense_Mutation | c.2209C>T | p.Arg737Cys | p.R737C | Q14004 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDK13 | SNV | Missense_Mutation | c.3226G>A | p.Val1076Met | p.V1076M | Q14004 | protein_coding | tolerated(0.12) | possibly_damaging(0.535) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDK13 | SNV | Missense_Mutation | c.3940N>T | p.Asp1314Tyr | p.D1314Y | Q14004 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.598) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDK13 | SNV | Missense_Mutation | novel | c.4101N>A | p.Ser1367Arg | p.S1367R | Q14004 | protein_coding | tolerated_low_confidence(0.06) | benign(0.298) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CDK13 | SNV | Missense_Mutation | novel | c.4508N>C | p.Gly1503Ala | p.G1503A | Q14004 | protein_coding | tolerated_low_confidence(1) | benign(0.097) | TCGA-AG-A032-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | bevacizumab | PD |
CDK13 | SNV | Missense_Mutation | c.4094N>A | p.Arg1365Gln | p.R1365Q | Q14004 | protein_coding | deleterious_low_confidence(0.01) | benign(0.003) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
CDK13 | SNV | Missense_Mutation | novel | c.2004G>T | p.Lys668Asn | p.K668N | Q14004 | protein_coding | tolerated(0.08) | possibly_damaging(0.714) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CDK13 | SNV | Missense_Mutation | novel | c.3272A>G | p.Glu1091Gly | p.E1091G | Q14004 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8621 | CDK13 | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | 375973251 | ||
8621 | CDK13 | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL3544942 | RONICICLIB | |
8621 | CDK13 | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL488436 | AZD-5438 | |
8621 | CDK13 | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL445813 | AT-7519 | |
8621 | CDK13 | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL1230607 | PHA-793887 |
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