![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CDH12 |
Gene summary for CDH12 |
![]() |
Gene information | Species | Human | Gene symbol | CDH12 | Gene ID | 1010 |
Gene name | cadherin 12 | |
Gene Alias | CDHB | |
Cytomap | 5p14.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | P55289 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1010 | CDH12 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.71e-04 | 2.69e-01 | -0.0811 |
1010 | CDH12 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.33e-10 | 3.67e-01 | -0.1088 |
1010 | CDH12 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.64e-14 | 3.82e-01 | -0.1954 |
1010 | CDH12 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.80e-02 | 2.27e-01 | -0.1207 |
1010 | CDH12 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.08e-02 | 1.70e-01 | -0.1001 |
1010 | CDH12 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.26e-11 | 4.27e-01 | -0.059 |
1010 | CDH12 | HTA11_4255_2000001011 | Human | Colorectum | SER | 9.19e-06 | 4.57e-01 | 0.0446 |
1010 | CDH12 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.95e-05 | 3.95e-01 | 0.0131 |
1010 | CDH12 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.99e-13 | 7.47e-01 | 0.0112 |
1010 | CDH12 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.54e-12 | 5.12e-01 | 0.0588 |
1010 | CDH12 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.66e-04 | 9.89e-01 | 0.3487 |
1010 | CDH12 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.77e-26 | 1.04e+00 | 0.281 |
1010 | CDH12 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.30e-23 | 5.47e-01 | 0.3859 |
1010 | CDH12 | A015-C-104 | Human | Colorectum | FAP | 3.61e-02 | -8.18e-02 | -0.1899 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045216 | Colorectum | AD | cell-cell junction organization | 80/3918 | 200/18723 | 5.57e-10 | 4.58e-08 | 80 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0007043 | Colorectum | AD | cell-cell junction assembly | 57/3918 | 146/18723 | 4.18e-07 | 1.61e-05 | 57 |
GO:0034332 | Colorectum | AD | adherens junction organization | 20/3918 | 49/18723 | 1.23e-03 | 1.09e-02 | 20 |
GO:00452161 | Colorectum | SER | cell-cell junction organization | 63/2897 | 200/18723 | 9.15e-09 | 7.80e-07 | 63 |
GO:00070431 | Colorectum | SER | cell-cell junction assembly | 45/2897 | 146/18723 | 2.23e-06 | 9.31e-05 | 45 |
GO:00343291 | Colorectum | SER | cell junction assembly | 100/2897 | 420/18723 | 4.23e-06 | 1.61e-04 | 100 |
GO:00452162 | Colorectum | MSS | cell-cell junction organization | 69/3467 | 200/18723 | 5.07e-08 | 2.70e-06 | 69 |
GO:00343292 | Colorectum | MSS | cell junction assembly | 120/3467 | 420/18723 | 2.51e-07 | 1.07e-05 | 120 |
GO:00070432 | Colorectum | MSS | cell-cell junction assembly | 50/3467 | 146/18723 | 4.24e-06 | 1.21e-04 | 50 |
GO:00343321 | Colorectum | MSS | adherens junction organization | 18/3467 | 49/18723 | 2.03e-03 | 1.74e-02 | 18 |
GO:00452163 | Colorectum | MSI-H | cell-cell junction organization | 28/1319 | 200/18723 | 3.82e-04 | 8.73e-03 | 28 |
GO:00070433 | Colorectum | MSI-H | cell-cell junction assembly | 20/1319 | 146/18723 | 3.18e-03 | 3.93e-02 | 20 |
GO:00343293 | Colorectum | FAP | cell junction assembly | 105/2622 | 420/18723 | 1.03e-09 | 2.18e-07 | 105 |
GO:00452164 | Colorectum | FAP | cell-cell junction organization | 58/2622 | 200/18723 | 2.51e-08 | 2.36e-06 | 58 |
GO:00070434 | Colorectum | FAP | cell-cell junction assembly | 39/2622 | 146/18723 | 3.74e-05 | 8.09e-04 | 39 |
GO:00343322 | Colorectum | FAP | adherens junction organization | 18/2622 | 49/18723 | 6.06e-05 | 1.19e-03 | 18 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDH12 | SNV | Missense_Mutation | rs143124599 | c.1358C>T | p.Ala453Val | p.A453V | P55289 | protein_coding | tolerated(0.19) | benign(0.035) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CDH12 | SNV | Missense_Mutation | rs371189490 | c.595G>A | p.Val199Ile | p.V199I | P55289 | protein_coding | tolerated(0.09) | probably_damaging(0.926) | TCGA-AD-6899-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
CDH12 | SNV | Missense_Mutation | novel | c.869N>T | p.Arg290Ile | p.R290I | P55289 | protein_coding | deleterious(0.02) | possibly_damaging(0.741) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CDH12 | SNV | Missense_Mutation | c.1572N>A | p.Phe524Leu | p.F524L | P55289 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-AZ-6600-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cpt-11 | PD | |
CDH12 | SNV | Missense_Mutation | c.1766T>C | p.Val589Ala | p.V589A | P55289 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CDH12 | SNV | Missense_Mutation | c.152N>A | p.Arg51His | p.R51H | P55289 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
CDH12 | SNV | Missense_Mutation | c.2242G>A | p.Ala748Thr | p.A748T | P55289 | protein_coding | deleterious(0.03) | probably_damaging(0.994) | TCGA-CM-6168-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CDH12 | SNV | Missense_Mutation | rs551198422 | c.1324G>A | p.Ala442Thr | p.A442T | P55289 | protein_coding | tolerated(0.53) | benign(0.348) | TCGA-G4-6310-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fu | SD |
CDH12 | SNV | Missense_Mutation | c.1382C>T | p.Ala461Val | p.A461V | P55289 | protein_coding | deleterious(0) | possibly_damaging(0.667) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CDH12 | SNV | Missense_Mutation | c.1505N>C | p.Lys502Thr | p.K502T | P55289 | protein_coding | deleterious(0.04) | possibly_damaging(0.515) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |