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Gene: CCDC14 |
Gene summary for CCDC14 |
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Gene information | Species | Human | Gene symbol | CCDC14 | Gene ID | 64770 |
Gene name | coiled-coil domain containing 14 | |
Gene Alias | CCDC14 | |
Cytomap | 3q21.1 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q49A88 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64770 | CCDC14 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 1.88e-06 | 3.01e-01 | 0.0208 |
64770 | CCDC14 | CCI_2 | Human | Cervix | CC | 9.64e-03 | 5.29e-01 | 0.5249 |
64770 | CCDC14 | CCI_3 | Human | Cervix | CC | 3.38e-14 | 9.19e-01 | 0.516 |
64770 | CCDC14 | sample3 | Human | Cervix | CC | 2.29e-07 | 3.21e-01 | 0.1387 |
64770 | CCDC14 | T1 | Human | Cervix | CC | 9.00e-05 | 3.71e-01 | 0.0918 |
64770 | CCDC14 | T3 | Human | Cervix | CC | 4.81e-12 | 3.09e-01 | 0.1389 |
64770 | CCDC14 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.29e-46 | -1.02e+00 | 0.0155 |
64770 | CCDC14 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.42e-26 | -9.32e-01 | -0.1808 |
64770 | CCDC14 | HTA11_2951_2000001011 | Human | Colorectum | AD | 7.46e-06 | -9.38e-01 | 0.0216 |
64770 | CCDC14 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.89e-16 | -8.08e-01 | -0.0811 |
64770 | CCDC14 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.06e-10 | -5.55e-01 | -0.1088 |
64770 | CCDC14 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.04e-04 | -3.98e-01 | -0.1954 |
64770 | CCDC14 | HTA11_411_2000001011 | Human | Colorectum | SER | 9.89e-04 | -7.86e-01 | -0.2602 |
64770 | CCDC14 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.18e-09 | -1.15e+00 | -0.2196 |
64770 | CCDC14 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.59e-23 | -1.04e+00 | -0.1207 |
64770 | CCDC14 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.32e-16 | -9.45e-01 | -0.1526 |
64770 | CCDC14 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.34e-52 | -9.10e-01 | -0.1464 |
64770 | CCDC14 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.51e-33 | -7.61e-01 | -0.1001 |
64770 | CCDC14 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.44e-34 | -9.89e-01 | -0.059 |
64770 | CCDC14 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.81e-06 | -8.79e-01 | -0.1706 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00309019 | Cervix | CC | midbrain development | 26/2311 | 90/18723 | 2.12e-05 | 3.82e-04 | 26 |
GO:002176210 | Cervix | CC | substantia nigra development | 16/2311 | 44/18723 | 3.81e-05 | 5.99e-04 | 16 |
GO:00488579 | Cervix | CC | neural nucleus development | 18/2311 | 64/18723 | 5.42e-04 | 5.23e-03 | 18 |
GO:0021762 | Colorectum | AD | substantia nigra development | 21/3918 | 44/18723 | 6.60e-05 | 1.07e-03 | 21 |
GO:0048857 | Colorectum | AD | neural nucleus development | 27/3918 | 64/18723 | 9.57e-05 | 1.45e-03 | 27 |
GO:0071539 | Colorectum | AD | protein localization to centrosome | 16/3918 | 33/18723 | 3.86e-04 | 4.41e-03 | 16 |
GO:1905508 | Colorectum | AD | protein localization to microtubule organizing center | 16/3918 | 35/18723 | 8.76e-04 | 8.51e-03 | 16 |
GO:0030901 | Colorectum | AD | midbrain development | 32/3918 | 90/18723 | 9.45e-04 | 8.95e-03 | 32 |
GO:00217621 | Colorectum | SER | substantia nigra development | 21/2897 | 44/18723 | 4.77e-07 | 2.40e-05 | 21 |
GO:00488571 | Colorectum | SER | neural nucleus development | 26/2897 | 64/18723 | 1.09e-06 | 5.11e-05 | 26 |
GO:00309011 | Colorectum | SER | midbrain development | 29/2897 | 90/18723 | 5.50e-05 | 1.30e-03 | 29 |
GO:00217622 | Colorectum | MSS | substantia nigra development | 21/3467 | 44/18723 | 9.54e-06 | 2.33e-04 | 21 |
GO:00488572 | Colorectum | MSS | neural nucleus development | 26/3467 | 64/18723 | 3.19e-05 | 6.30e-04 | 26 |
GO:00715391 | Colorectum | MSS | protein localization to centrosome | 16/3467 | 33/18723 | 8.66e-05 | 1.40e-03 | 16 |
GO:19055081 | Colorectum | MSS | protein localization to microtubule organizing center | 16/3467 | 35/18723 | 2.07e-04 | 2.89e-03 | 16 |
GO:00309012 | Colorectum | MSS | midbrain development | 31/3467 | 90/18723 | 2.36e-04 | 3.24e-03 | 31 |
GO:0044380 | Colorectum | MSS | protein localization to cytoskeleton | 19/3467 | 58/18723 | 6.69e-03 | 4.38e-02 | 19 |
GO:0072698 | Colorectum | MSS | protein localization to microtubule cytoskeleton | 18/3467 | 54/18723 | 6.70e-03 | 4.38e-02 | 18 |
GO:00715392 | Colorectum | FAP | protein localization to centrosome | 14/2622 | 33/18723 | 6.39e-05 | 1.23e-03 | 14 |
GO:19055082 | Colorectum | FAP | protein localization to microtubule organizing center | 14/2622 | 35/18723 | 1.38e-04 | 2.18e-03 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC14 | insertion | Frame_Shift_Ins | novel | c.1671_1672insA | p.Glu558ArgfsTer13 | p.E558Rfs*13 | Q49A88 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CCDC14 | deletion | Frame_Shift_Del | c.1145delA | p.Asn382MetfsTer2 | p.N382Mfs*2 | Q49A88 | protein_coding | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
CCDC14 | SNV | Missense_Mutation | rs867199884 | c.1834N>A | p.Asp612Asn | p.D612N | Q49A88 | protein_coding | deleterious(0) | benign(0.185) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CCDC14 | SNV | Missense_Mutation | novel | c.883N>A | p.Leu295Met | p.L295M | Q49A88 | protein_coding | tolerated(0.05) | possibly_damaging(0.74) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CCDC14 | SNV | Missense_Mutation | novel | c.581N>A | p.Ala194Asp | p.A194D | Q49A88 | protein_coding | tolerated(0.13) | benign(0.219) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC14 | SNV | Missense_Mutation | c.1814N>A | p.Ser605Asn | p.S605N | Q49A88 | protein_coding | deleterious(0.05) | possibly_damaging(0.698) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCDC14 | SNV | Missense_Mutation | novel | c.1535A>G | p.Glu512Gly | p.E512G | Q49A88 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC14 | SNV | Missense_Mutation | c.1404N>T | p.Gln468His | p.Q468H | Q49A88 | protein_coding | deleterious(0) | benign(0.006) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
CCDC14 | SNV | Missense_Mutation | c.476G>T | p.Arg159Ile | p.R159I | Q49A88 | protein_coding | deleterious(0.04) | possibly_damaging(0.735) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
CCDC14 | SNV | Missense_Mutation | rs370975951 | c.995G>A | p.Arg332Gln | p.R332Q | Q49A88 | protein_coding | tolerated(1) | benign(0.001) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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