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Gene: CCDC102B |
Gene summary for CCDC102B |
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Gene information | Species | Human | Gene symbol | CCDC102B | Gene ID | 79839 |
Gene name | coiled-coil domain containing 102B | |
Gene Alias | ACY1L | |
Cytomap | 18q22.1-q22.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q68D86 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79839 | CCDC102B | ATC11 | Human | Thyroid | ATC | 1.02e-03 | 3.45e-01 | 0.3386 |
79839 | CCDC102B | ATC12 | Human | Thyroid | ATC | 1.09e-24 | 7.71e-01 | 0.34 |
79839 | CCDC102B | ATC13 | Human | Thyroid | ATC | 3.42e-58 | 1.18e+00 | 0.34 |
79839 | CCDC102B | ATC4 | Human | Thyroid | ATC | 8.80e-33 | 9.55e-01 | 0.34 |
79839 | CCDC102B | ATC5 | Human | Thyroid | ATC | 4.74e-67 | 1.24e+00 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC102B | SNV | Missense_Mutation | novel | c.629C>A | p.Ser210Tyr | p.S210Y | Q68D86 | protein_coding | deleterious(0.01) | possibly_damaging(0.558) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC102B | SNV | Missense_Mutation | novel | c.860G>T | p.Arg287Ile | p.R287I | Q68D86 | protein_coding | deleterious(0.01) | benign(0.325) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC102B | SNV | Missense_Mutation | c.1254A>C | p.Glu418Asp | p.E418D | Q68D86 | protein_coding | tolerated(0.2) | benign(0.09) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCDC102B | SNV | Missense_Mutation | novel | c.402G>T | p.Leu134Phe | p.L134F | Q68D86 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC102B | SNV | Missense_Mutation | c.468N>T | p.Gln156His | p.Q156H | Q68D86 | protein_coding | tolerated(0.58) | possibly_damaging(0.639) | TCGA-AJ-A3OL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
CCDC102B | SNV | Missense_Mutation | c.742N>A | p.Leu248Met | p.L248M | Q68D86 | protein_coding | tolerated(0.17) | benign(0.121) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCDC102B | SNV | Missense_Mutation | novel | c.433C>T | p.Pro145Ser | p.P145S | Q68D86 | protein_coding | tolerated(0.83) | benign(0.003) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC102B | SNV | Missense_Mutation | novel | c.1306C>G | p.Gln436Glu | p.Q436E | Q68D86 | protein_coding | tolerated(0.1) | benign(0.272) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC102B | SNV | Missense_Mutation | novel | c.1377G>T | p.Lys459Asn | p.K459N | Q68D86 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
CCDC102B | SNV | Missense_Mutation | novel | c.277N>T | p.Arg93Trp | p.R93W | Q68D86 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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