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Gene: CAPN5 |
Gene summary for CAPN5 |
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Gene information | Species | Human | Gene symbol | CAPN5 | Gene ID | 726 |
Gene name | calpain 5 | |
Gene Alias | ADNIV | |
Cytomap | 11q13.5 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A0A140VKH4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
726 | CAPN5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.16e-05 | 5.63e-01 | -0.1808 |
726 | CAPN5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.48e-02 | 2.60e-01 | -0.0811 |
726 | CAPN5 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.80e-32 | 8.31e-01 | -0.1954 |
726 | CAPN5 | HTA11_411_2000001011 | Human | Colorectum | SER | 6.71e-12 | 1.35e+00 | -0.2602 |
726 | CAPN5 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.31e-04 | 8.14e-01 | -0.2196 |
726 | CAPN5 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.57e-04 | 4.61e-01 | -0.1526 |
726 | CAPN5 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.84e-11 | 5.93e-01 | -0.1464 |
726 | CAPN5 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.13e-04 | 4.27e-01 | -0.1001 |
726 | CAPN5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.13e-08 | 5.20e-01 | -0.059 |
726 | CAPN5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.23e-03 | -2.40e-01 | 0.294 |
726 | CAPN5 | A002-C-010 | Human | Colorectum | FAP | 2.47e-04 | -1.78e-01 | 0.242 |
726 | CAPN5 | A015-C-203 | Human | Colorectum | FAP | 2.45e-12 | -2.12e-01 | -0.1294 |
726 | CAPN5 | A002-C-201 | Human | Colorectum | FAP | 2.31e-02 | -1.78e-01 | 0.0324 |
726 | CAPN5 | A001-C-108 | Human | Colorectum | FAP | 2.95e-06 | -2.45e-01 | -0.0272 |
726 | CAPN5 | A002-C-205 | Human | Colorectum | FAP | 4.11e-07 | -3.00e-01 | -0.1236 |
726 | CAPN5 | A001-C-104 | Human | Colorectum | FAP | 4.17e-02 | -1.53e-01 | 0.0184 |
726 | CAPN5 | A015-C-006 | Human | Colorectum | FAP | 2.49e-04 | -2.51e-01 | -0.0994 |
726 | CAPN5 | A015-C-106 | Human | Colorectum | FAP | 3.15e-07 | -1.82e-01 | -0.0511 |
726 | CAPN5 | A002-C-114 | Human | Colorectum | FAP | 2.42e-04 | -2.33e-01 | -0.1561 |
726 | CAPN5 | A015-C-104 | Human | Colorectum | FAP | 7.70e-13 | -2.68e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPN5 | SNV | Missense_Mutation | rs369500943 | c.961N>A | p.Gly321Ser | p.G321S | O15484 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-AX-A06D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
CAPN5 | SNV | Missense_Mutation | rs369845664 | c.1177G>A | p.Glu393Lys | p.E393K | O15484 | protein_coding | deleterious(0.01) | benign(0.059) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAPN5 | SNV | Missense_Mutation | novel | c.699N>T | p.Lys233Asn | p.K233N | O15484 | protein_coding | tolerated(0.09) | possibly_damaging(0.838) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
CAPN5 | SNV | Missense_Mutation | rs371777752 | c.1024N>A | p.Val342Met | p.V342M | O15484 | protein_coding | tolerated(0.07) | benign(0.249) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
CAPN5 | SNV | Missense_Mutation | c.1769A>G | p.Glu590Gly | p.E590G | O15484 | protein_coding | tolerated(0.16) | possibly_damaging(0.538) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
CAPN5 | SNV | Missense_Mutation | rs199504989 | c.185N>A | p.Arg62His | p.R62H | O15484 | protein_coding | tolerated(0.8) | benign(0.001) | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD |
CAPN5 | SNV | Missense_Mutation | rs140490506 | c.1496N>A | p.Arg499His | p.R499H | O15484 | protein_coding | tolerated(0.48) | benign(0.361) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAPN5 | SNV | Missense_Mutation | novel | c.1669N>G | p.Thr557Ala | p.T557A | O15484 | protein_coding | tolerated(0.05) | benign(0.098) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPN5 | SNV | Missense_Mutation | novel | c.1580N>T | p.Ala527Val | p.A527V | O15484 | protein_coding | tolerated(0.14) | benign(0.035) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPN5 | SNV | Missense_Mutation | rs369845664 | c.1177N>A | p.Glu393Lys | p.E393K | O15484 | protein_coding | deleterious(0.01) | benign(0.059) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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