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Gene: CAPN13 |
Gene summary for CAPN13 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CAPN13 | Gene ID | 92291 |
Gene name | calpain 13 | |
Gene Alias | CAPN13 | |
Cytomap | 2p23.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q6MZZ7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92291 | CAPN13 | LZE5T | Human | Esophagus | ESCC | 1.54e-04 | 4.90e-01 | 0.0514 |
92291 | CAPN13 | LZE24T | Human | Esophagus | ESCC | 1.89e-10 | 2.66e-01 | 0.0596 |
92291 | CAPN13 | P1T-E | Human | Esophagus | ESCC | 1.09e-04 | 2.22e-01 | 0.0875 |
92291 | CAPN13 | P8T-E | Human | Esophagus | ESCC | 3.02e-26 | 6.95e-01 | 0.0889 |
92291 | CAPN13 | P15T-E | Human | Esophagus | ESCC | 3.38e-04 | 2.52e-01 | 0.1149 |
92291 | CAPN13 | P23T-E | Human | Esophagus | ESCC | 6.53e-09 | 2.49e-01 | 0.108 |
92291 | CAPN13 | P36T-E | Human | Esophagus | ESCC | 2.82e-02 | 1.59e-01 | 0.1187 |
92291 | CAPN13 | P57T-E | Human | Esophagus | ESCC | 9.35e-10 | 3.11e-01 | 0.0926 |
92291 | CAPN13 | P61T-E | Human | Esophagus | ESCC | 2.11e-11 | 3.17e-01 | 0.099 |
92291 | CAPN13 | P62T-E | Human | Esophagus | ESCC | 8.96e-66 | 1.81e+00 | 0.1302 |
92291 | CAPN13 | P65T-E | Human | Esophagus | ESCC | 2.64e-10 | 2.41e-01 | 0.0978 |
92291 | CAPN13 | P76T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.67e-01 | 0.1207 |
92291 | CAPN13 | P79T-E | Human | Esophagus | ESCC | 2.06e-08 | 2.84e-01 | 0.1154 |
92291 | CAPN13 | P80T-E | Human | Esophagus | ESCC | 1.97e-04 | 2.82e-01 | 0.155 |
92291 | CAPN13 | P82T-E | Human | Esophagus | ESCC | 1.40e-05 | 3.53e-01 | 0.1072 |
92291 | CAPN13 | P84T-E | Human | Esophagus | ESCC | 2.04e-06 | 4.93e-01 | 0.0933 |
92291 | CAPN13 | P104T-E | Human | Esophagus | ESCC | 2.06e-06 | 3.35e-01 | 0.0931 |
92291 | CAPN13 | P126T-E | Human | Esophagus | ESCC | 8.75e-03 | 5.07e-01 | 0.1125 |
92291 | CAPN13 | P127T-E | Human | Esophagus | ESCC | 7.67e-11 | 2.40e-01 | 0.0826 |
92291 | CAPN13 | RNA-P17T-P17T-2 | Human | Lung | IAC | 2.46e-03 | 5.95e-01 | 0.3371 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPN13 | SNV | Missense_Mutation | rs565060477 | c.898C>T | p.Arg300Trp | p.R300W | Q6MZZ7 | protein_coding | tolerated(0.22) | benign(0.045) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CAPN13 | SNV | Missense_Mutation | novel | c.956A>G | p.Asp319Gly | p.D319G | Q6MZZ7 | protein_coding | deleterious(0.02) | probably_damaging(0.986) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
CAPN13 | SNV | Missense_Mutation | novel | c.1643N>T | p.Ala548Val | p.A548V | Q6MZZ7 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAPN13 | SNV | Missense_Mutation | rs751792504 | c.899N>A | p.Arg300Gln | p.R300Q | Q6MZZ7 | protein_coding | tolerated(0.3) | benign(0.035) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPN13 | SNV | Missense_Mutation | rs369616026 | c.896N>T | p.Pro299Leu | p.P299L | Q6MZZ7 | protein_coding | tolerated(0.12) | possibly_damaging(0.537) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPN13 | SNV | Missense_Mutation | rs766688300 | c.1937G>A | p.Arg646His | p.R646H | Q6MZZ7 | protein_coding | tolerated(0.42) | benign(0) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CAPN13 | SNV | Missense_Mutation | novel | c.1082N>A | p.Thr361Asn | p.T361N | Q6MZZ7 | protein_coding | tolerated(0.22) | possibly_damaging(0.522) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPN13 | SNV | Missense_Mutation | rs369616026 | c.896N>T | p.Pro299Leu | p.P299L | Q6MZZ7 | protein_coding | tolerated(0.12) | possibly_damaging(0.537) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPN13 | SNV | Missense_Mutation | rs773969358 | c.1328N>A | p.Arg443His | p.R443H | Q6MZZ7 | protein_coding | tolerated(0.57) | benign(0.098) | TCGA-D1-A16Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAPN13 | SNV | Missense_Mutation | novel | c.1119C>A | p.Phe373Leu | p.F373L | Q6MZZ7 | protein_coding | deleterious(0.02) | possibly_damaging(0.715) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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