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Gene: C20orf194 |
Gene summary for C20ORF194 |
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Gene information | Species | Human | Gene symbol | C20orf194 | Gene ID | 25943 |
Gene name | dynein axonemal assembly factor 9 | |
Gene Alias | C20orf194 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q0IIP3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25943 | C20orf194 | LZE4T | Human | Esophagus | ESCC | 1.10e-10 | 4.32e-01 | 0.0811 |
25943 | C20orf194 | LZE24T | Human | Esophagus | ESCC | 7.75e-08 | 1.49e-01 | 0.0596 |
25943 | C20orf194 | P1T-E | Human | Esophagus | ESCC | 4.65e-04 | 2.63e-01 | 0.0875 |
25943 | C20orf194 | P2T-E | Human | Esophagus | ESCC | 2.25e-14 | 1.33e-01 | 0.1177 |
25943 | C20orf194 | P4T-E | Human | Esophagus | ESCC | 7.90e-07 | 1.79e-01 | 0.1323 |
25943 | C20orf194 | P5T-E | Human | Esophagus | ESCC | 4.34e-06 | 8.66e-02 | 0.1327 |
25943 | C20orf194 | P8T-E | Human | Esophagus | ESCC | 4.15e-14 | 1.46e-01 | 0.0889 |
25943 | C20orf194 | P9T-E | Human | Esophagus | ESCC | 1.66e-08 | 2.58e-01 | 0.1131 |
25943 | C20orf194 | P10T-E | Human | Esophagus | ESCC | 9.75e-33 | 6.74e-01 | 0.116 |
25943 | C20orf194 | P11T-E | Human | Esophagus | ESCC | 1.78e-10 | 5.00e-01 | 0.1426 |
25943 | C20orf194 | P12T-E | Human | Esophagus | ESCC | 1.58e-23 | 5.90e-01 | 0.1122 |
25943 | C20orf194 | P15T-E | Human | Esophagus | ESCC | 3.39e-11 | 3.01e-01 | 0.1149 |
25943 | C20orf194 | P16T-E | Human | Esophagus | ESCC | 3.28e-13 | 2.96e-01 | 0.1153 |
25943 | C20orf194 | P17T-E | Human | Esophagus | ESCC | 1.51e-03 | 2.04e-01 | 0.1278 |
25943 | C20orf194 | P20T-E | Human | Esophagus | ESCC | 5.38e-11 | 1.94e-01 | 0.1124 |
25943 | C20orf194 | P21T-E | Human | Esophagus | ESCC | 3.46e-15 | 3.23e-01 | 0.1617 |
25943 | C20orf194 | P22T-E | Human | Esophagus | ESCC | 6.04e-11 | 1.36e-01 | 0.1236 |
25943 | C20orf194 | P23T-E | Human | Esophagus | ESCC | 1.76e-05 | 1.57e-01 | 0.108 |
25943 | C20orf194 | P24T-E | Human | Esophagus | ESCC | 1.79e-07 | 8.29e-02 | 0.1287 |
25943 | C20orf194 | P26T-E | Human | Esophagus | ESCC | 9.25e-48 | 1.25e+00 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C20orf194 | SNV | Missense_Mutation | novel | c.2462N>T | p.Thr821Ile | p.T821I | Q5TEA3 | protein_coding | tolerated(0.34) | benign(0.007) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
C20orf194 | SNV | Missense_Mutation | novel | c.1379N>G | p.Ile460Ser | p.I460S | Q5TEA3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
C20orf194 | SNV | Missense_Mutation | novel | c.688N>A | p.Asp230Asn | p.D230N | Q5TEA3 | protein_coding | tolerated(0.07) | benign(0.031) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
C20orf194 | SNV | Missense_Mutation | rs779631164 | c.305N>T | p.Ser102Leu | p.S102L | Q5TEA3 | protein_coding | tolerated(0.32) | benign(0.005) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
C20orf194 | SNV | Missense_Mutation | rs368687225 | c.313N>A | p.Val105Ile | p.V105I | Q5TEA3 | protein_coding | tolerated(0.07) | benign(0.028) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
C20orf194 | SNV | Missense_Mutation | c.1642C>A | p.Leu548Ile | p.L548I | Q5TEA3 | protein_coding | tolerated(0.72) | benign(0.013) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C20orf194 | SNV | Missense_Mutation | rs757003738 | c.853C>T | p.Arg285Trp | p.R285W | Q5TEA3 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C20orf194 | SNV | Missense_Mutation | novel | c.2924T>C | p.Ile975Thr | p.I975T | Q5TEA3 | protein_coding | deleterious(0.05) | probably_damaging(0.99) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C20orf194 | SNV | Missense_Mutation | c.2213C>T | p.Thr738Ile | p.T738I | Q5TEA3 | protein_coding | deleterious(0.04) | benign(0.062) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C20orf194 | SNV | Missense_Mutation | c.776C>T | p.Ser259Phe | p.S259F | Q5TEA3 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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