![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: C1orf116 |
Gene summary for C1ORF116 |
![]() |
Gene information | Species | Human | Gene symbol | C1orf116 | Gene ID | 79098 |
Gene name | chromosome 1 open reading frame 116 | |
Gene Alias | SARG | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9BW04 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79098 | C1orf116 | LZE4T | Human | Esophagus | ESCC | 3.70e-02 | 6.12e-03 | 0.0811 |
79098 | C1orf116 | LZE24T | Human | Esophagus | ESCC | 1.91e-18 | 8.34e-01 | 0.0596 |
79098 | C1orf116 | P1T-E | Human | Esophagus | ESCC | 1.02e-04 | 5.10e-01 | 0.0875 |
79098 | C1orf116 | P4T-E | Human | Esophagus | ESCC | 9.28e-08 | 3.87e-03 | 0.1323 |
79098 | C1orf116 | P5T-E | Human | Esophagus | ESCC | 1.98e-13 | 8.21e-02 | 0.1327 |
79098 | C1orf116 | P8T-E | Human | Esophagus | ESCC | 2.92e-10 | 1.65e-01 | 0.0889 |
79098 | C1orf116 | P9T-E | Human | Esophagus | ESCC | 8.85e-04 | 1.75e-01 | 0.1131 |
79098 | C1orf116 | P10T-E | Human | Esophagus | ESCC | 2.14e-04 | -4.81e-02 | 0.116 |
79098 | C1orf116 | P15T-E | Human | Esophagus | ESCC | 1.38e-04 | -7.09e-02 | 0.1149 |
79098 | C1orf116 | P17T-E | Human | Esophagus | ESCC | 2.12e-04 | 1.98e-01 | 0.1278 |
79098 | C1orf116 | P20T-E | Human | Esophagus | ESCC | 1.05e-03 | 1.94e-02 | 0.1124 |
79098 | C1orf116 | P21T-E | Human | Esophagus | ESCC | 5.29e-13 | 2.40e-01 | 0.1617 |
79098 | C1orf116 | P22T-E | Human | Esophagus | ESCC | 1.66e-02 | -5.22e-02 | 0.1236 |
79098 | C1orf116 | P23T-E | Human | Esophagus | ESCC | 2.29e-09 | 4.20e-01 | 0.108 |
79098 | C1orf116 | P26T-E | Human | Esophagus | ESCC | 2.89e-10 | -3.67e-03 | 0.1276 |
79098 | C1orf116 | P27T-E | Human | Esophagus | ESCC | 3.03e-02 | -1.66e-02 | 0.1055 |
79098 | C1orf116 | P28T-E | Human | Esophagus | ESCC | 1.81e-10 | 9.25e-02 | 0.1149 |
79098 | C1orf116 | P31T-E | Human | Esophagus | ESCC | 3.78e-13 | 2.77e-01 | 0.1251 |
79098 | C1orf116 | P32T-E | Human | Esophagus | ESCC | 7.83e-03 | -9.54e-02 | 0.1666 |
79098 | C1orf116 | P36T-E | Human | Esophagus | ESCC | 1.51e-09 | 2.44e-01 | 0.1187 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1orf116 | SNV | Missense_Mutation | rs750528994 | c.170N>T | p.Thr57Ile | p.T57I | Q9BW04 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf116 | SNV | Missense_Mutation | novel | c.1355A>G | p.Asn452Ser | p.N452S | Q9BW04 | protein_coding | tolerated(0.47) | benign(0.033) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
C1orf116 | SNV | Missense_Mutation | rs770424183 | c.971G>A | p.Arg324His | p.R324H | Q9BW04 | protein_coding | tolerated(0.24) | benign(0.025) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
C1orf116 | SNV | Missense_Mutation | novel | c.144G>T | p.Lys48Asn | p.K48N | Q9BW04 | protein_coding | deleterious(0) | benign(0.181) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
C1orf116 | SNV | Missense_Mutation | novel | c.1787N>C | p.Leu596Pro | p.L596P | Q9BW04 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf116 | SNV | Missense_Mutation | rs531699068 | c.1138C>T | p.Arg380Trp | p.R380W | Q9BW04 | protein_coding | tolerated(0.22) | benign(0.319) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf116 | SNV | Missense_Mutation | c.104N>T | p.Ser35Phe | p.S35F | Q9BW04 | protein_coding | tolerated(0.75) | benign(0.051) | TCGA-BG-A0W1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C1orf116 | SNV | Missense_Mutation | c.833N>A | p.Ala278Asp | p.A278D | Q9BW04 | protein_coding | deleterious(0.01) | benign(0.191) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C1orf116 | SNV | Missense_Mutation | c.802G>T | p.Gly268Trp | p.G268W | Q9BW04 | protein_coding | tolerated(0.09) | benign(0.163) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C1orf116 | SNV | Missense_Mutation | rs140606489 | c.613N>T | p.Arg205Trp | p.R205W | Q9BW04 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |