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Gene: BTNL8 |
Gene summary for BTNL8 |
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Gene information | Species | Human | Gene symbol | BTNL8 | Gene ID | 79908 |
Gene name | butyrophilin like 8 | |
Gene Alias | BTN9.2 | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | Q6UX41 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79908 | BTNL8 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.54e-09 | 6.08e-01 | -0.1808 |
79908 | BTNL8 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.79e-14 | 7.40e-01 | -0.1954 |
79908 | BTNL8 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.67e-04 | 1.14e+00 | -0.2602 |
79908 | BTNL8 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.70e-04 | 8.07e-01 | -0.2196 |
79908 | BTNL8 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.13e-02 | 3.73e-01 | -0.1207 |
79908 | BTNL8 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.35e-04 | 5.13e-01 | -0.1526 |
79908 | BTNL8 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.13e-03 | 3.89e-01 | -0.1464 |
79908 | BTNL8 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.55e-08 | 9.09e-01 | -0.2061 |
79908 | BTNL8 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.73e-02 | -2.45e-01 | 0.3005 |
79908 | BTNL8 | A002-C-205 | Human | Colorectum | FAP | 2.20e-02 | -2.09e-01 | -0.1236 |
79908 | BTNL8 | A002-C-114 | Human | Colorectum | FAP | 4.93e-02 | -2.11e-01 | -0.1561 |
79908 | BTNL8 | A002-C-116 | Human | Colorectum | FAP | 1.88e-02 | -1.59e-01 | -0.0452 |
79908 | BTNL8 | F072B | Human | Colorectum | FAP | 1.05e-08 | 5.28e-01 | 0.257 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BTNL8 | SNV | Missense_Mutation | novel | c.771C>A | p.Phe257Leu | p.F257L | Q6UX41 | protein_coding | tolerated(0.49) | benign(0.024) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BTNL8 | SNV | Missense_Mutation | c.410T>C | p.Val137Ala | p.V137A | Q6UX41 | protein_coding | tolerated(0.55) | benign(0.003) | TCGA-BS-A0UM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
BTNL8 | SNV | Missense_Mutation | c.319T>A | p.Leu107Met | p.L107M | Q6UX41 | protein_coding | tolerated(0.06) | possibly_damaging(0.832) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BTNL8 | SNV | Missense_Mutation | c.1394N>T | p.Glu465Val | p.E465V | Q6UX41 | protein_coding | tolerated(0.29) | benign(0.009) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BTNL8 | SNV | Missense_Mutation | rs768102519 | c.859N>A | p.Ala287Thr | p.A287T | Q6UX41 | protein_coding | tolerated(0.14) | benign(0.092) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BTNL8 | SNV | Missense_Mutation | novel | c.818N>A | p.Arg273Lys | p.R273K | Q6UX41 | protein_coding | tolerated(0.23) | benign(0) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
BTNL8 | SNV | Missense_Mutation | novel | c.1138C>T | p.Leu380Phe | p.L380F | Q6UX41 | protein_coding | tolerated(0.27) | benign(0.169) | TCGA-EO-A3L0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BTNL8 | SNV | Missense_Mutation | c.1192N>A | p.Val398Ile | p.V398I | Q6UX41 | protein_coding | tolerated(0.09) | benign(0) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BTNL8 | SNV | Missense_Mutation | novel | c.187N>A | p.Val63Met | p.V63M | Q6UX41 | protein_coding | deleterious(0) | probably_damaging(0.909) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BTNL8 | SNV | Missense_Mutation | rs770261754 | c.1075N>T | p.Arg359Trp | p.R359W | Q6UX41 | protein_coding | deleterious(0.05) | benign(0.038) | TCGA-PG-A6IB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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